| + |
CyclinY/CDK16 | down-regulates quantity by destabilization 
phosphorylation
|
CDKN1B |
0.338 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-273012 |
Ser10 |
NVRVSNGsPSLERMD |
Homo sapiens |
HeLa Cell |
| pmid |
sentence |
| 25205104 |
In vitro kinase assays showed PCTAIRE1 phosphorylates p27 at Ser10. PCTAIRE1 silencing modulated Ser10 phosphorylation on p27 and led to its accumulation in cancer cells but not in nontransformed cells.|Together our findings reveal an unexpected role for PCTAIRE1 in regulating p27 stability, mitosis, and tumor growth, suggesting PCTAIRE1 as a candidate cancer therapeutic target. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
CyclinY/CDK16 | up-regulates activity 
phosphorylation
|
CDK16 |
0.691 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-273006 |
Ser336 |
PPDILLGsTDYSTQI |
|
|
| pmid |
sentence |
| 32723157 |
Mechanistically the S326 phosphorylation by AMPK promotes the interaction of CCNY with CDK16, which in turn autophosphorylates S336, which serves as a marker for active CCNY-CDK16. |
|
| Publications: |
1 |
| + |
CyclinY/CDK16 | up-regulates activity
phosphorylation
|
PRKAR1A |
0.275 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-273014 |
Ser83 |
DSREDEIsPPPPNPV |
Homo sapiens |
HeLa Cell |
| pmid |
sentence |
| 25605337 |
PCTK1 regulates spindle orientation in a kinase-dependent manner. Phosphoproteomic analysis together with an RNA interference screen revealed that PCTK1 regulates spindle orientation through phosphorylation of Ser83 on KAP0, a regulatory subunit of protein kinase A (PKA) |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
CyclinY/CDK16 | up-regulates activity
phosphorylation
|
PRC1 |
0.35 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-273013 |
Thr481 |
RRGLAPNtPGKARKL |
Homo sapiens |
MDA-MB-231 Cell |
| pmid |
sentence |
| 35449080 |
Mechanistically, CDK16 exerts its function by phosphorylating protein regulator of cytokinesis 1 (PRC1) to regulate spindle formation during mitosis.|Indeed, immunoblot analysis showed that PRC1 phosphorylation at the T481 site (CDK-dependent major phosphorylation site) fluctuated with the abundance of CDK16 protein in the cell cycle process |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
CDK16 | form complex 
binding
|
CyclinY/CDK16 |
0.691 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-273003 |
|
|
|
|
| pmid |
sentence |
| 30992425 |
CDK16 (also known as PCTAIRE1 or PCTK1) is an atypical member of the cyclin-dependent kinase (CDK) family that forms an active complex with cyclin Y (CCNY). |
|
| Publications: |
1 |
| + |
CCNY | form complex
binding
|
CyclinY/CDK16 |
0.691 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-273002 |
|
|
|
|
| pmid |
sentence |
| 30992425 |
CDK16 (also known as PCTAIRE1 or PCTK1) is an atypical member of the cyclin-dependent kinase (CDK) family that forms an active complex with cyclin Y (CCNY). |
|
| Publications: |
1 |
3.0
CyclinY/CDK16
CPX-379