Summary

Name TNRC6A
Full Name Trinucleotide repeat-containing gene 6A protein
Synonyms CAG repeat protein 26, EMSY interactor protein, GW182 autoantigen, Protein GW1, Glycine-tryptophan protein of 182 kDa | CAGH26, KIAA1460, TNRC6
Primary ID Q8NDV7
Links - -
Type protein
Relations 1
Function Plays a role in RNA-mediated gene silencing by both micro-RNAs (miRNAs) and short interfering RNAs (siRNAs). Required for miRNA-dependent repression of translation and for siRNA-dependent endonucleolytic cleavage of complementary mRNAs by argonaute family proteins. As a scaffolding protein, associates with argonaute proteins bound to partially complementary mRNAs, and can simultaneously recruit CCR4-NOT and PAN deadenylase complexes. {ECO:0000269|PubMed:16284622, ECO:0000269|PubMed:16284623, ECO:0000269|PubMed:17596515, ECO:0000269|PubMed:17671087, ECO:0000269|PubMed:19056672, ECO:0000269|PubMed:19304925}.

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Relations

Regulator Mechanism target score ℹ
+ TRIM65down-regulates quantity by destabilization img/direct_inhibition.png polyubiquitination TNRC6A 0.457
Publications: 1 Organism: Homo Sapiens