| + |
PRKCE | up-regulates activity 
phosphorylation
|
TRPV1 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-249230 |
Ser502 |
YFLQRRPsMKTLFVD |
Chlorocebus aethiops |
COS-7 Cell |
| pmid |
sentence |
| 14523239 |
We found that mutation of S800 to alanine significantly reduced the PMA-induced enhancement of capsaicin-evoked currents and the direct activation of TRPV1 by PMA. Mutation of S502 to alanine reduced PMA enhancement of capsaicin-evoked currents, but had no effect on direct activation of TRPV1 by PMA. Conversely, mutation of T704 to alanine had no effect on PMA enhancement of capsaicin-evoked currents but dramatically reduced direct activation of TRPV1 by PMA. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-249141 |
Ser502 |
YFLQRRPsMKTLFVD |
Homo sapiens |
HEK-293 Cell |
| pmid |
sentence |
| 11884385 |
Direct phosphorylation of capsaicin receptor VR1 by protein kinase Cepsilon and identification of two target serine residues. | Patch clamp analysis of the point mutants where Ser or Thr residues were replaced with Ala in the total 16 putative phosphorylation sites showed that two Ser residues, Ser(502) and Ser(800) were involved in the potentiation of the capsaicin-evoked currents by either PMA or ATP. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-249231 |
Ser775 |
EGVKRTLsFSLRSSR |
Chlorocebus aethiops |
COS-7 Cell |
| pmid |
sentence |
| 14523239 |
We found that mutation of S800 to alanine significantly reduced the PMA-induced enhancement of capsaicin-evoked currents and the direct activation of TRPV1 by PMA. Mutation of S502 to alanine reduced PMA enhancement of capsaicin-evoked currents, but had no effect on direct activation of TRPV1 by PMA. Conversely, mutation of T704 to alanine had no effect on PMA enhancement of capsaicin-evoked currents but dramatically reduced direct activation of TRPV1 by PMA. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-249142 |
Ser801 |
VPLLREAsARDRQSA |
Homo sapiens |
HEK-293 Cell |
| pmid |
sentence |
| 11884385 |
Direct phosphorylation of capsaicin receptor VR1 by protein kinase Cepsilon and identification of two target serine residues. | Patch clamp analysis of the point mutants where Ser or Thr residues were replaced with Ala in the total 16 putative phosphorylation sites showed that two Ser residues, Ser(502) and Ser(800) were involved in the potentiation of the capsaicin-evoked currents by either PMA or ATP. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-249232 |
Ser801 |
VPLLREAsARDRQSA |
Chlorocebus aethiops |
|
| pmid |
sentence |
| 14523239 |
We found that mutation of S800 to alanine significantly reduced the PMA-induced enhancement of capsaicin-evoked currents and the direct activation of TRPV1 by PMA. Mutation of S502 to alanine reduced PMA enhancement of capsaicin-evoked currents, but had no effect on direct activation of TRPV1 by PMA. Conversely, mutation of T704 to alanine had no effect on PMA enhancement of capsaicin-evoked currents but dramatically reduced direct activation of TRPV1 by PMA. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-249233 |
Ser821 |
YLRQFSGsLKPEDAE |
Chlorocebus aethiops |
COS-7 Cell |
| pmid |
sentence |
| 14523239 |
We found that mutation of S800 to alanine significantly reduced the PMA-induced enhancement of capsaicin-evoked currents and the direct activation of TRPV1 by PMA. Mutation of S502 to alanine reduced PMA enhancement of capsaicin-evoked currents, but had no effect on direct activation of TRPV1 by PMA. Conversely, mutation of T704 to alanine had no effect on PMA enhancement of capsaicin-evoked currents but dramatically reduced direct activation of TRPV1 by PMA. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-249234 |
Thr145 |
QKSKKHLtDNEFKDP |
in vitro |
|
| pmid |
sentence |
| 14523239 |
We found that mutation of S800 to alanine significantly reduced the PMA-induced enhancement of capsaicin-evoked currents and the direct activation of TRPV1 by PMA. Mutation of S502 to alanine reduced PMA enhancement of capsaicin-evoked currents, but had no effect on direct activation of TRPV1 by PMA. Conversely, mutation of T704 to alanine had no effect on PMA enhancement of capsaicin-evoked currents but dramatically reduced direct activation of TRPV1 by PMA. | Edman sequencing and scintillation counting delineated T144 as the in vitro PKC phosphorylation site |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-249235 |
Thr705 |
WKLQRAItILDTEKS |
Chlorocebus aethiops |
COS-7 Cell |
| pmid |
sentence |
| 14523239 |
We found that mutation of S800 to alanine significantly reduced the PMA-induced enhancement of capsaicin-evoked currents and the direct activation of TRPV1 by PMA. Mutation of S502 to alanine reduced PMA enhancement of capsaicin-evoked currents, but had no effect on direct activation of TRPV1 by PMA. Conversely, mutation of T704 to alanine had no effect on PMA enhancement of capsaicin-evoked currents but dramatically reduced direct activation of TRPV1 by PMA. |
|
| Publications: |
8 |
Organism: |
Chlorocebus Aethiops, Homo Sapiens, In Vitro |
| + |
PRKCB | up-regulates activity
phosphorylation
|
TRPV1 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-276638 |
Thr705 |
WKLQRAItILDTEKS |
Homo sapiens |
HEK-293 Cell |
| pmid |
sentence |
| 24920628 |
PKCβII causes the downregulation of TRPV1 by phosphorylating the channel. The increased threonine phosphorylation was substantially reduced by mutating Thr705, showing that Thr705 is indeed a major PKCβII phosphorylation site. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
PTPN6 | down-regulates activity 
dephosphorylation
|
TRPV1 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-277129 |
|
|
Rattus norvegicus |
|
| pmid |
sentence |
| 25790452 |
Shp-1 dephosphorylates TRPV1 in dorsal root ganglion neurons and alleviates CFA-induced inflammatory pain in rats.|These results suggested that Shp-1 dephosphorylated and inhibited TRPV1 in DRG neurons, contributing to maintain thermal nociceptive thresholds in normal rats, and as a compensatory mechanism, Shp-1 increased in DRGs of rats with CFA-induced inflammatory pain, which was involved in protecting against excessive thermal hyperalgesia. |
|
| Publications: |
1 |
Organism: |
Rattus Norvegicus |
| + |
TRPV1 | up-regulates activity
binding
|
PRKCB |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-276639 |
|
|
Homo sapiens |
HEK-293 Cell |
| pmid |
sentence |
| 24920628 |
In the present study, we report that the sensitivity of TRPV1 channels is determined by PKCβII. TRPV1 binds directly to PKCβII and subsequently activates PKCβII. Activated PKCβII then enhances the responsiveness of TRPV1 to thermal and chemical stimuli through a phosphorylation-dependent mechanism. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
SB-705498 | down-regulates
chemical inhibition
|
TRPV1 |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-206826 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| Other |
|
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
3.0
TRPV1
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