+ |
PRKCE | up-regulates activity
phosphorylation
|
TRPV1 |
0.2 |
Identifier |
Residue |
Sequence |
Organism |
Cell Line |
SIGNOR-249230 |
Ser502 |
YFLQRRPsMKTLFVD |
Chlorocebus aethiops |
COS-7 Cell |
pmid |
sentence |
14523239 |
We found that mutation of S800 to alanine significantly reduced the PMA-induced enhancement of capsaicin-evoked currents and the direct activation of TRPV1 by PMA. Mutation of S502 to alanine reduced PMA enhancement of capsaicin-evoked currents, but had no effect on direct activation of TRPV1 by PMA. Conversely, mutation of T704 to alanine had no effect on PMA enhancement of capsaicin-evoked currents but dramatically reduced direct activation of TRPV1 by PMA. |
|
Identifier |
Residue |
Sequence |
Organism |
Cell Line |
SIGNOR-249141 |
Ser502 |
YFLQRRPsMKTLFVD |
Homo sapiens |
HEK-293 Cell |
pmid |
sentence |
11884385 |
Direct phosphorylation of capsaicin receptor VR1 by protein kinase Cepsilon and identification of two target serine residues. | Patch clamp analysis of the point mutants where Ser or Thr residues were replaced with Ala in the total 16 putative phosphorylation sites showed that two Ser residues, Ser(502) and Ser(800) were involved in the potentiation of the capsaicin-evoked currents by either PMA or ATP. |
|
Identifier |
Residue |
Sequence |
Organism |
Cell Line |
SIGNOR-249231 |
Ser775 |
EGVKRTLsFSLRSSR |
Chlorocebus aethiops |
COS-7 Cell |
pmid |
sentence |
14523239 |
We found that mutation of S800 to alanine significantly reduced the PMA-induced enhancement of capsaicin-evoked currents and the direct activation of TRPV1 by PMA. Mutation of S502 to alanine reduced PMA enhancement of capsaicin-evoked currents, but had no effect on direct activation of TRPV1 by PMA. Conversely, mutation of T704 to alanine had no effect on PMA enhancement of capsaicin-evoked currents but dramatically reduced direct activation of TRPV1 by PMA. |
|
Identifier |
Residue |
Sequence |
Organism |
Cell Line |
SIGNOR-249232 |
Ser801 |
VPLLREAsARDRQSA |
Chlorocebus aethiops |
|
pmid |
sentence |
14523239 |
We found that mutation of S800 to alanine significantly reduced the PMA-induced enhancement of capsaicin-evoked currents and the direct activation of TRPV1 by PMA. Mutation of S502 to alanine reduced PMA enhancement of capsaicin-evoked currents, but had no effect on direct activation of TRPV1 by PMA. Conversely, mutation of T704 to alanine had no effect on PMA enhancement of capsaicin-evoked currents but dramatically reduced direct activation of TRPV1 by PMA. |
|
Identifier |
Residue |
Sequence |
Organism |
Cell Line |
SIGNOR-249142 |
Ser801 |
VPLLREAsARDRQSA |
Homo sapiens |
HEK-293 Cell |
pmid |
sentence |
11884385 |
Direct phosphorylation of capsaicin receptor VR1 by protein kinase Cepsilon and identification of two target serine residues. | Patch clamp analysis of the point mutants where Ser or Thr residues were replaced with Ala in the total 16 putative phosphorylation sites showed that two Ser residues, Ser(502) and Ser(800) were involved in the potentiation of the capsaicin-evoked currents by either PMA or ATP. |
|
Identifier |
Residue |
Sequence |
Organism |
Cell Line |
SIGNOR-249233 |
Ser821 |
YLRQFSGsLKPEDAE |
Chlorocebus aethiops |
COS-7 Cell |
pmid |
sentence |
14523239 |
We found that mutation of S800 to alanine significantly reduced the PMA-induced enhancement of capsaicin-evoked currents and the direct activation of TRPV1 by PMA. Mutation of S502 to alanine reduced PMA enhancement of capsaicin-evoked currents, but had no effect on direct activation of TRPV1 by PMA. Conversely, mutation of T704 to alanine had no effect on PMA enhancement of capsaicin-evoked currents but dramatically reduced direct activation of TRPV1 by PMA. |
|
Identifier |
Residue |
Sequence |
Organism |
Cell Line |
SIGNOR-249234 |
Thr145 |
QKSKKHLtDNEFKDP |
in vitro |
|
pmid |
sentence |
14523239 |
We found that mutation of S800 to alanine significantly reduced the PMA-induced enhancement of capsaicin-evoked currents and the direct activation of TRPV1 by PMA. Mutation of S502 to alanine reduced PMA enhancement of capsaicin-evoked currents, but had no effect on direct activation of TRPV1 by PMA. Conversely, mutation of T704 to alanine had no effect on PMA enhancement of capsaicin-evoked currents but dramatically reduced direct activation of TRPV1 by PMA. | Edman sequencing and scintillation counting delineated T144 as the in vitro PKC phosphorylation site |
|
Identifier |
Residue |
Sequence |
Organism |
Cell Line |
SIGNOR-249235 |
Thr705 |
WKLQRAItILDTEKS |
Chlorocebus aethiops |
COS-7 Cell |
pmid |
sentence |
14523239 |
We found that mutation of S800 to alanine significantly reduced the PMA-induced enhancement of capsaicin-evoked currents and the direct activation of TRPV1 by PMA. Mutation of S502 to alanine reduced PMA enhancement of capsaicin-evoked currents, but had no effect on direct activation of TRPV1 by PMA. Conversely, mutation of T704 to alanine had no effect on PMA enhancement of capsaicin-evoked currents but dramatically reduced direct activation of TRPV1 by PMA. |
|
Publications: |
8 |
Organism: |
Chlorocebus Aethiops, Homo Sapiens, In Vitro |
+ |
SB-705498 | down-regulates
chemical inhibition
|
TRPV1 |
0.8 |
Identifier |
Residue |
Sequence |
Organism |
Cell Line |
SIGNOR-206826 |
|
|
Homo sapiens |
|
pmid |
sentence |
Other |
|
|
Publications: |
1 |
Organism: |
Homo Sapiens |