Summary

Name FBXO22
Full Name F-box only protein 22
Synonyms F-box protein FBX22p44 | FBX22
Primary ID Q8NEZ5
Links - -
Type protein
Relations 10
Function Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex. Promotes the proteasome-dependent degradation of key sarcomeric proteins, such as alpha-actinin (ACTN2) and filamin-C (FLNC), essential for maintenance of normal contractile function.

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Relations

Regulator Mechanism target score
+ down-regulates quantity img/direct_inhibition.png ubiquitination BACH1 0.284
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png binding Cullin 1-RBX1-Skp1 0.566
Publications: 1 Organism: Homo Sapiens
+ down-regulates quantity by destabilization img/direct_inhibition.png ubiquitination SNAI1 0.2
Publications: 1 Organism: Homo Sapiens
+ down-regulates quantity by destabilization img/direct_inhibition.png binding, ubiquitination BSG 0.441
Publications: 2 Organism: Homo Sapiens
+ down-regulates quantity by destabilization img/direct_inhibition.png ubiquitination KDM4A 0.35
Publications: 1 Organism: Homo Sapiens
+ down-regulates quantity by destabilization img/direct_inhibition.png ubiquitination KLF4 0.373
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png chemical activation FBXO22 0.8
Publications: 1 Organism: Homo Sapiens
+ down-regulates quantity by destabilization img/direct_inhibition.png ubiquitination MDM2 0.2
Publications: 1 Organism: Homo Sapiens
+ down-regulates quantity by destabilization img/direct_inhibition.png ubiquitination TP53 0.349
Publications: 1 Organism: Homo Sapiens