4.0
Summary
| Name |  LPCAT1View Modifications |
| Full Name | Lysophosphatidylcholine acyltransferase 1 |
| Synonyms | LPC acyltransferase 1, LPCAT-1, LysoPC acyltransferase 1, EC 2.3.1.23, 1-acylglycerol-3-phosphate O-acyltransferase, EC 2.3.1.51, 1-acylglycerophosphocholine O-acyltransferase, 1-alkenylglycerophosphocholine O-acyltransferase, EC 2.3.1.25, 1-alkylglycerophosphocholine O-acetyltransferase, EC 2.3.1.67, Acetyl-CoA:lyso-platelet-activating factor acetyltransferase, Acetyl-CoA:lyso-PAF acetyltransferase, Lyso-PAF acetyltransferase, LysoPAFAT, Acyltransferase-like 2, Phosphonoformate immuno-associated protein 3 | AYTL2, PFAAP3 |
| Primary ID | Q8NF37 |
| Links |  -  -  |
| Type | protein |
| Relations | 5 |
| Function | Exhibits acyltransferase activity (PubMed:21498505, PubMed:18156367). Exhibits acetyltransferase activity (By similarity). Activity is calcium-independent (By similarity). Catalyzes the conversion of lysophosphatidylcholine (1-acyl-sn-glycero-3-phosphocholine or LPC) into phosphatidylcholine (1,2-diacyl-sn-glycero-3-phosphocholine or PC) (PubMed:21498505, PubMed:18156367). Catalyzes the conversion 1-acyl-sn-glycerol-3-phosphate (lysophosphatidic acid or LPA) into 1,2-diacyl-sn-glycerol-3-phosphate (phosphatidic acid or PA) by incorporating an acyl moiety at the sn-2 position of the glycerol backbone (By similarity). Displays a clear preference for saturated fatty acyl-CoAs, and 1-myristoyl or 1-palmitoyl LPC as acyl donors and acceptors, respectively (By similarity). Involved in platelet-activating factor (PAF) biosynthesis by catalyzing the conversion of the PAF precursor, 1-O-alkyl-sn-glycero-3-phosphocholine (lyso-PAF) into 1-O-alkyl-2-acetyl-sn-glycero-3-phosphocholine (PAF) (By similarity). May synthesize phosphatidylcholine in pulmonary surfactant, thereby playing a pivotal role in respiratory physiology (By similarity). Involved in the regulation of lipid droplet number and size (PubMed:25491198). {ECO:0000250|UniProtKB:Q3TFD2, ECO:0000269|PubMed:18156367, ECO:0000269|PubMed:21498505, ECO:0000269|PubMed:25491198}. |
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Modifications Tables
Relations
| Regulator | Mechanism | target | score ℹ | |
|---|---|---|---|---|
| + | SCF-betaTRCP | down-regulates quantity by destabilization 
polyubiquitination
|
LPCAT1 | 0.327 |
| Publications: | 1 | Organism: | Mus Musculus | |
| + | LPCAT1 | down-regulates quantity
chemical modification
|
1-O-acyl-sn-glycero-3-phosphocholine | 0.8 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | LPCAT1 | up-regulates quantity 
chemical modification
|
1,2-diacyl-sn-glycero-3-phosphocholine | 0.8 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | LPCAT1 | down-regulates quantity
chemical modification
|
acyl-CoA(4-) | 0.8 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | LPCAT1 | up-regulates quantity
chemical modification
|
coenzyme A(4-) | 0.8 |
| Publications: | 1 | Organism: | Homo Sapiens | |