Relation Results

Summary

Name NBEA
Full Name Neurobeachin
Synonyms Lysosomal-trafficking regulator 2, Protein BCL8B | BCL8B, KIAA1544, LYST2
Primary ID Q8NFP9
Links - -
Type protein
Relations 2
Function Binds to type II regulatory subunits of protein kinase A and anchors/targets them to the membrane. May anchor the kinase to cytoskeletal and/or organe ...
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Type: Score: Layout: SPV 
0.3090.429NBEANOTCH1DLG3

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Relations
Regulator
Mechanism
target
score ℹ
+ NBEAdown-regulates activity img/direct_inhibition.png binding NOTCH1 0.309
Identifier Residue Sequence Organism Cell Line
SIGNOR-266010 Homo sapiens HEK-293 Cell
pmid sentence
Yeast two-hybrid identified the Notch1 intracellular domain as a physical interactor of the PBW domain and a role for NBEA as a negative regulator in Notch-mediated transcription was demonstrated.|Defining novel interaction partners of conserved NBEA domain modules identified a role for NBEA as transcriptional regulator in the nucleus. The physical interaction of NBEA with NOTCH1 is most relevant for ASD pathogenesis because NOTCH signaling is essential for neural development.
Publications: 1 Organism: Homo Sapiens
Tissue: Central Nervous System
+ NBEAup-regulates activity img/direct-activation.png binding DLG3 0.429
Identifier Residue Sequence Organism Cell Line
SIGNOR-266004
pmid sentence
Interestingly, a recent proteomic analysis (Lauks et al., 2012) revealed that Nbea binds SAP102, which interacts with glutamate receptors early in the biosynthetic route and regulates their targeting. This finding, along with the interaction of Nbea with the glycine receptor beta subunit (del Pino et al., 2011), further strengthens the notion that Nbea targets neurotransmitter receptors to synapses.
Publications: 1
Tissue: Central Nervous System
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