Summary

Name PREX1
Full Name Phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 1 protein
Synonyms P-Rex1, PtdIns(3,4,5)-dependent Rac exchanger 1 | KIAA1415
Primary ID Q8TCU6
Links - -
Type protein
Relations 2
Function Functions as a RAC guanine nucleotide exchange factor (GEF), which activates the Rac proteins by exchanging bound GDP for free GTP. Its activity is synergistically activated by phosphatidylinositol 3,4,5-trisphosphate and the beta gamma subunits of heterotrimeric G protein. May function downstream of heterotrimeric G proteins in neutrophils.

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Relations

Regulator Mechanism target score
+ up-regulates activity img/direct-activation.png guanine nucleotide exchange factor RAC1 0.705
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png binding PREX1 0.256
Publications: 1 Organism: Mus Musculus