| + |
AUTS2 | up-regulates activity 
binding
|
PREX1 |
0.253 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-266817 |
|
|
Mus musculus |
N1E-115 Cell |
| pmid |
sentence |
| 25533347 |
Mutations in the Autism susceptibility candidate 2 gene (AUTS2), whose protein is believed to act in neuronal cell nuclei, have been associated with multiple psychiatric illnesses, including autism spectrum disorders, intellectual disability, and schizophrenia. Here we show that cytoplasmic AUTS2 is involved in the regulation of the cytoskeleton and neural development. AUTS2 activates Rac1 to induce lamellipodia but downregulates Cdc42 to suppress filopodia. Our loss-of-function and rescue experiments show that a cytoplasmic AUTS2-Rac1 pathway is involved in cortical neuronal migration and neuritogenesis in the developing brain. These results suggest that FL-AUTS2 can activate Rac1 via interaction with P-Rex1 and the Elmo2/Dock180 complex to regulate actin dynamics in N1E-115 cells. |
|
| Publications: |
1 |
Organism: |
Mus Musculus |
| + |
AUTS2 | up-regulates activity
binding
|
ELMO2 |
0.27 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-266819 |
|
|
Mus musculus |
N1E-115 Cell |
| pmid |
sentence |
| 25533347 |
Mutations in the Autism susceptibility candidate 2 gene (AUTS2), whose protein is believed to act in neuronal cell nuclei, have been associated with multiple psychiatric illnesses, including autism spectrum disorders, intellectual disability, and schizophrenia. Here we show that cytoplasmic AUTS2 is involved in the regulation of the cytoskeleton and neural development. AUTS2 activates Rac1 to induce lamellipodia but downregulates Cdc42 to suppress filopodia. Our loss-of-function and rescue experiments show that a cytoplasmic AUTS2-Rac1 pathway is involved in cortical neuronal migration and neuritogenesis in the developing brain. These results suggest that FL-AUTS2 can activate Rac1 via interaction with P-Rex1 and the Elmo2/Dock180 complex to regulate actin dynamics in N1E-115 cells. |
|
| Publications: |
1 |
Organism: |
Mus Musculus |
| + |
AUTS2 | down-regulates activity 
binding
|
Polycomb repressive complex 1 |
0.362 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-266814 |
|
|
Homo sapiens |
HEK-293 Cell |
| pmid |
sentence |
| 25519132 |
We investigated the role of AUTS2 as part of a previously identified PRC1 complex (PRC1-AUTS2), and in the context of neurodevelopment. In contrast to the canonical role of PRC1 in gene repression, PRC1-AUTS2 activates transcription. Biochemical studies demonstrate that the CK2 component of PRC1-AUTS2 neutralizes PRC1 repressive activity, whereas AUTS2-mediated recruitment of P300 leads to gene activation. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
AUTS2 | up-regulates activity
binding
|
DOCK1 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-266820 |
|
|
Mus musculus |
N1E-115 Cell |
| pmid |
sentence |
| 25533347 |
Mutations in the Autism susceptibility candidate 2 gene (AUTS2), whose protein is believed to act in neuronal cell nuclei, have been associated with multiple psychiatric illnesses, including autism spectrum disorders, intellectual disability, and schizophrenia. Here we show that cytoplasmic AUTS2 is involved in the regulation of the cytoskeleton and neural development. AUTS2 activates Rac1 to induce lamellipodia but downregulates Cdc42 to suppress filopodia. Our loss-of-function and rescue experiments show that a cytoplasmic AUTS2-Rac1 pathway is involved in cortical neuronal migration and neuritogenesis in the developing brain. These results suggest that FL-AUTS2 can activate Rac1 via interaction with P-Rex1 and the Elmo2/Dock180 complex to regulate actin dynamics in N1E-115 cells. |
|
| Publications: |
1 |
Organism: |
Mus Musculus |
| + |
FOXP2 | up-regulates quantity by expression
transcriptional regulation
|
AUTS2 |
0.327 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-266832 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 25232744 |
By interacting with CASK, TBR1 regulates several ASD candidate genes, such as GRIN2B, AUTS2 and RELN—all of which are recurrently mutated in ASD. In areas of the brain with overlapping expression patterns, such as in glutamatergic layer 6 neurons, the TBR1–FOXP2 interaction may result in co-ordinated regulation of common downstream targets. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Tissue: |
Brain |
| + |
AUTS2 | up-regulates 
|
Neuron_migration |
0.7 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-266816 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 28505103 |
Cytoplasmic AUTS2 regulates actin cytoskeleton to control neuronal migration and neurite extension, while nuclear AUTS2 controls transcription of various genes as a component of the polycomb complex 1 (PRC1). |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
AUTS2 | up-regulates
|
Neurite_outgrowth |
0.7 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-266818 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 25533347 |
AUTS2 is involved in neurite outgrowth and branch formation in neurons. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
TBR1 | up-regulates quantity by expression
transcriptional regulation
|
AUTS2 |
0.361 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-266836 |
|
|
Mus musculus |
|
| pmid |
sentence |
| 20615956 |
Tbr1 implements frontal identity in part by direct promoter binding and activation of Auts2, a frontal cortex gene implicated in autism. |
|
| Publications: |
1 |
Organism: |
Mus Musculus |
| Tissue: |
Brain |
3.0
AUTS2
- 
- 