Relation Results

Summary

Name AUTS2
Full Name Autism susceptibility gene 2 protein
Synonyms AUTS2_HUMAN | KIAA0442
Primary ID Q8WXX7
Links - -
Type protein
Relations 8
Function Component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of man ...
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Type: Score: Layout: SPV 
0.20.3270.70.70.3610.2530.270.362AUTS2DOCK1FOXP2Neuron_migrationNeurite_outgrowthTBR1PREX1ELMO2Polycomb repressive complex 1

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Relations
Regulator
Mechanism
target
score ℹ
+ AUTS2up-regulates activity img/direct-activation.png binding DOCK1 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-266820 Mus musculus N1E-115 Cell
pmid sentence
Mutations in the Autism susceptibility candidate 2 gene (AUTS2), whose protein is believed to act in neuronal cell nuclei, have been associated with multiple psychiatric illnesses, including autism spectrum disorders, intellectual disability, and schizophrenia. Here we show that cytoplasmic AUTS2 is involved in the regulation of the cytoskeleton and neural development.  AUTS2 activates Rac1 to induce lamellipodia but downregulates Cdc42 to suppress filopodia. Our loss-of-function and rescue experiments show that a cytoplasmic AUTS2-Rac1 pathway is involved in cortical neuronal migration and neuritogenesis in the developing brain. These results suggest that FL-AUTS2 can activate Rac1 via interaction with P-Rex1 and the Elmo2/Dock180 complex to regulate actin dynamics in N1E-115 cells.
Publications: 1 Organism: Mus Musculus
+ FOXP2up-regulates quantity by expression img/direct-activation.png transcriptional regulation AUTS2 0.327
Identifier Residue Sequence Organism Cell Line
SIGNOR-266832 Homo sapiens
pmid sentence
By interacting with CASK, TBR1 regulates several ASD candidate genes, such as GRIN2B, AUTS2 and RELN—all of which are recurrently mutated in ASD. In areas of the brain with overlapping expression patterns, such as in glutamatergic layer 6 neurons, the TBR1–FOXP2 interaction may result in co-ordinated regulation of common downstream targets.
Publications: 1 Organism: Homo Sapiens
Tissue: Brain
+ AUTS2up-regulates img/indirect-activation.png Neuron_migration 0.7
Identifier Residue Sequence Organism Cell Line
SIGNOR-266816 Homo sapiens
pmid sentence
Cytoplasmic AUTS2 regulates actin cytoskeleton to control neuronal migration and neurite extension, while nuclear AUTS2 controls transcription of various genes as a component of the polycomb complex 1 (PRC1).
Publications: 1 Organism: Homo Sapiens
+ AUTS2up-regulates img/indirect-activation.png Neurite_outgrowth 0.7
Identifier Residue Sequence Organism Cell Line
SIGNOR-266818 Homo sapiens
pmid sentence
AUTS2 is involved in neurite outgrowth and branch formation in neurons.
Publications: 1 Organism: Homo Sapiens
+ TBR1up-regulates quantity by expression img/direct-activation.png transcriptional regulation AUTS2 0.361
Identifier Residue Sequence Organism Cell Line
SIGNOR-266836 Mus musculus
pmid sentence
Tbr1 implements frontal identity in part by direct promoter binding and activation of Auts2, a frontal cortex gene implicated in autism.
Publications: 1 Organism: Mus Musculus
Tissue: Brain
+ AUTS2up-regulates activity img/direct-activation.png binding PREX1 0.253
Identifier Residue Sequence Organism Cell Line
SIGNOR-266817 Mus musculus N1E-115 Cell
pmid sentence
Mutations in the Autism susceptibility candidate 2 gene (AUTS2), whose protein is believed to act in neuronal cell nuclei, have been associated with multiple psychiatric illnesses, including autism spectrum disorders, intellectual disability, and schizophrenia. Here we show that cytoplasmic AUTS2 is involved in the regulation of the cytoskeleton and neural development.  AUTS2 activates Rac1 to induce lamellipodia but downregulates Cdc42 to suppress filopodia. Our loss-of-function and rescue experiments show that a cytoplasmic AUTS2-Rac1 pathway is involved in cortical neuronal migration and neuritogenesis in the developing brain. These results suggest that FL-AUTS2 can activate Rac1 via interaction with P-Rex1 and the Elmo2/Dock180 complex to regulate actin dynamics in N1E-115 cells.
Publications: 1 Organism: Mus Musculus
+ AUTS2up-regulates activity img/direct-activation.png binding ELMO2 0.27
Identifier Residue Sequence Organism Cell Line
SIGNOR-266819 Mus musculus N1E-115 Cell
pmid sentence
Mutations in the Autism susceptibility candidate 2 gene (AUTS2), whose protein is believed to act in neuronal cell nuclei, have been associated with multiple psychiatric illnesses, including autism spectrum disorders, intellectual disability, and schizophrenia. Here we show that cytoplasmic AUTS2 is involved in the regulation of the cytoskeleton and neural development.  AUTS2 activates Rac1 to induce lamellipodia but downregulates Cdc42 to suppress filopodia. Our loss-of-function and rescue experiments show that a cytoplasmic AUTS2-Rac1 pathway is involved in cortical neuronal migration and neuritogenesis in the developing brain. These results suggest that FL-AUTS2 can activate Rac1 via interaction with P-Rex1 and the Elmo2/Dock180 complex to regulate actin dynamics in N1E-115 cells.
Publications: 1 Organism: Mus Musculus
+ AUTS2down-regulates activity img/direct_inhibition.png binding Polycomb repressive complex 1 0.362
Identifier Residue Sequence Organism Cell Line
SIGNOR-266814 Homo sapiens HEK-293 Cell
pmid sentence
We investigated the role of AUTS2 as part of a previously identified PRC1 complex (PRC1-AUTS2), and in the context of neurodevelopment. In contrast to the canonical role of PRC1 in gene repression, PRC1-AUTS2 activates transcription. Biochemical studies demonstrate that the CK2 component of PRC1-AUTS2 neutralizes PRC1 repressive activity, whereas AUTS2-mediated recruitment of P300 leads to gene activation.
Publications: 1 Organism: Homo Sapiens
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