Summary

Name RB1CC1
Full Name RB1-inducible coiled-coil protein 1
Synonyms FAK family kinase-interacting protein of 200 kDa, FIP200 | KIAA0203, RBICC
Primary ID Q8TDY2
Links - -
Type protein
Relations 4
Function Involved in autophagy (PubMed:21775823). Regulates early events but also late events of autophagosome formation through direct interaction with Atg16L1 (PubMed:23392225). Required for the formation of the autophagosome-like double-membrane structure that surrounds the Salmonella-containing vacuole (SCV) during S.typhimurium infection and subsequent xenophagy (By similarity). Involved in repair of DNA damage caused by ionizing radiation, which subsequently improves cell survival by decreasing apoptosis (By similarity). Inhibits PTK2/FAK1 and PTK2B/PYK2 kinase activity, affecting their downstream signaling pathways (PubMed:10769033, PubMed:12221124). Plays a role as a modulator of TGF-beta-signaling by restricting substrate specificity of RNF111 (By similarity). Functions as a DNA-binding transcription factor (PubMed:12095676). Is a potent regulator of the RB1 pathway through induction of RB1 expression (PubMed:14533007). Plays a crucial role in muscular differentiation (PubMed:12163359). Plays an indispensable role in fetal hematopoiesis and in the regulation of neuronal homeostasis (By similarity).

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Relations

Regulator Mechanism target score ℹ
+ RB1CC1form complex img/form-complex.png binding ULK1/Atg13/Fip200 0.916
Publications: 1 Organism: Homo Sapiens
+ ULK1up-regulates img/direct-activation.png phosphorylation RB1CC1 0.913
Publications: 1 Organism: Homo Sapiens
+ ULK2up-regulates activity img/direct-activation.png phosphorylation RB1CC1 0.747
Publications: 1 Organism: Homo Sapiens
+ ATG13up-regulates img/direct-activation.png binding RB1CC1 0.919
Publications: 1 Organism: Homo Sapiens