Summary

Name DOK4
Full Name Docking protein 4
Synonyms Downstream of tyrosine kinase 4, Insulin receptor substrate 5, IRS-5, IRS5
Primary ID Q8TEW6
Links - -
Type protein
Relations 5
Function DOK proteins are enzymatically inert adaptor or scaffolding proteins. They provide a docking platform for the assembly of multimolecular signaling complexes. DOK4 functions in RET-mediated neurite outgrowth and plays a positive role in activation of the MAP kinase pathway (By similarity). Putative link with downstream effectors of RET in neuronal differentiation. May be involved in the regulation of the immune response induced by T-cells.

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Relations

Regulator Mechanism target score ℹ
+ DOK4up-regulates img/direct-activation.png binding CRK 0.476
Publications: 1 Organism: Homo Sapiens
Tissue: Muscle, Skeletal Muscle, Kidney
+ RETup-regulates img/direct-activation.png binding DOK4 0.552
Publications: 1 Organism: Homo Sapiens
+ INSRup-regulates img/indirect-activation.png DOK4 0.378
Publications: 1 Organism: Homo Sapiens
Tissue: Muscle, Skeletal Muscle, Kidney
+ DOK4up-regulates img/direct-activation.png binding SRC 0.43
Publications: 1 Organism: Homo Sapiens
Tissue: Muscle, Skeletal Muscle, Kidney
+ DOK4up-regulates img/direct-activation.png binding FYN 0.557
Publications: 1 Organism: Homo Sapiens
Tissue: Muscle, Skeletal Muscle, Kidney