Relation Results

Name	WHAMM
Full Name	WASP homolog-associated protein with actin, membranes and microtubules
Synonyms	WAS protein homology region 2 domain-containing protein 1, WH2 domain-containing protein 1 \| KIAA1971, WHDC1
Primary ID	Q8TF30
Links	- -
Type	protein
Relations	1
Function	Acts as a nucleation-promoting factor (NPF) that stimulates Arp2/3-mediated actin polymerization both at the Golgi apparatus and along tubular membranes. Its activity in membrane tubulation requires F-actin and interaction with microtubules. Proposed to use coordinated actin-nucleating and microtubule-binding activities of distinct WHAMM molecules to drive membrane tubule elongation; when MT-bound can recruit and remodel membrane vesicles but is prevented to activate the Arp2/3 complex. Involved as a regulator of Golgi positioning and morphology. Participates in vesicle transport between the reticulum endoplasmic and the Golgi complex. Required for RhoD-dependent actin reorganization such as in cell adhesion and cell migration.