Summary

Name WHAMM
Full Name WASP homolog-associated protein with actin, membranes and microtubules
Synonyms WAS protein homology region 2 domain-containing protein 1, WH2 domain-containing protein 1 | KIAA1971, WHDC1
Primary ID Q8TF30
Links - -
Type protein
Relations 1
Function Acts as a nucleation-promoting factor (NPF) that stimulates Arp2/3-mediated actin polymerization both at the Golgi apparatus and along tubular membranes. Its activity in membrane tubulation requires F-actin and interaction with microtubules. Proposed to use coordinated actin-nucleating and microtubule-binding activities of distinct WHAMM molecules to drive membrane tubule elongation; when MT-bound can recruit and remodel membrane vesicles but is prevented to activate the Arp2/3 complex. Involved as a regulator of Golgi positioning and morphology. Participates in vesicle transport between the reticulum endoplasmic and the Golgi complex. Required for RhoD-dependent actin reorganization such as in cell adhesion and cell migration.

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Relations

Regulator Mechanism target score ℹ
+ WHAMMup-regulates activity img/direct-activation.png binding ARP2/3 0.361
Publications: 1 Organism: Homo Sapiens