Relation Results

Summary

Name H3C1
Full Name Histone H3.1
Synonyms Histone H3/a, Histone H3/b, Histone H3/c, Histone H3/d, Histone H3/f, Histone H3/h, Histone H3/i, Histone H3/j, Histone H3/k, Histone H3/l | H3FA, HIST1H3B, HIST1H3C, HIST1H3D, HIST1H3E, HIST1H3F, HIST1H3G, HIST1H3H, HIST1H3I, HIST1H3J, HIST1H3B, HIST1H3C, HIST1H3D, HIST1H3E, HIST1H3F, HIST1H3G, HIST1H3H, HIST1H3I, HIST1H3J, HIST1H3B, HIST1H3C, HIST1H3D, HIST1H3E, HIST1H3F, HIST1H3G, HIST1H3H, HIST1H3I, HIST1H3J, HIST1H3B, HIST1H3C, HIST1H3D, HIST1H3E, HIST1H3F, HIST1H3G, HIST1H3H, HIST1H3I, HIST1H3J, H3C2, H3C3, H3C4, H3C6, H3C7, H3C8, H3C10, H3C11, H3C12, H3C2, H3C3, H3C4, H3C6, H3C7, H3C8, H3C10, H3C11, H3C12, H3C2, H3C3, H3C4, H3C6, H3C7, H3C8, H3C10, H3C11, H3C12
Primary ID P68431
Links - -
Type protein
Relations 75
Function Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DN ...
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0.20.20.20.20.20.20.20.20.20.20.20.20.20.20.20.20.20.20.20.20.20.20.20.20.20.20.20.20.20.20.20.20.20.20.20.20.20.20.20.20.20.20.20.20.20.20.20.20.20.20.20.20.70.20.20.20.2SETDB2H3C1KAT2AJMJD1CKDM4BKDM4CKAT2BKDM3BSAGA complexPHF2SIRT7Polycomb repressive complex 2KDM6AKDM6BSETD5SETD2ASH1LKDM1AMLL1 complexKDM5BMLL3 complexMLL2 complexSETD1BKDM5CSet1-Ash2 HMT complexKDM5AKDM5DDOT1LPIM1AURKATGM2TLK1CDK8PAK1AURKCRPS6KA5AURKBRPS6KA3CKM complexVRK1PBKMAPK14PIMHASPINPRKCDCBX3CTNNB1BAZ2BNucleosome_H2A.Z.2 variantCBX1CPCMAML1Nucleosome_H3.1 variantTranscritpional_activationSin3B_complexCBX5SLBPNucleosome_H2A.Z.1 variant

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▶Modifications Tables

Relations
Regulator
Mechanism
target
score ℹ
+ SETDB2up-regulates activity img/direct-activation.png methylation H3C1 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-263896 Lys 10 RTKQTARkSTGGKAP Homo sapiens HEK-293 Cell
pmid sentence
Here, we have characterized a previously undescribed member of the histone H3K9 methyltransferase family named CLLD8 (or SETDB2 or KMT1F). This protein contributes to the trimethylation of both interspersed repetitive elements and centromere-associated repeats and participates in the recruitment of heterochromatin protein 1 to centromeres. Methylation of histone H3 at lysine 9 (H3K9) has emerged as an important player in the formation of heterochromatin, chromatin condensation, and transcriptional repression.
Publications: 1 Organism: Homo Sapiens
+ KAT2Adown-regulates activity img/direct_inhibition.png acetylation H3C1 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-269594 Lys10 RTKQTARkSTGGKAP Homo sapiens
pmid sentence
The HAT module within the SAGA and ADA complexes acetylates histone H3, mainly on residues K9 and K14.
Identifier Residue Sequence Organism Cell Line
SIGNOR-269602 Lys15 ARKSTGGkAPRKQLA Homo sapiens
pmid sentence
The HAT module within the SAGA and ADA complexes acetylates histone H3, mainly on residues K9 and K14.
Publications: 2 Organism: Homo Sapiens
+ JMJD1Cdown-regulates activity img/direct_inhibition.png demethylation H3C1 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-265171 Lys10 RTKQTARkSTGGKAP Homo sapiens
pmid sentence
We now determine that JMJD1C is recruited by USF-1 to various lipogenic genes for H3K9 demethylation to enhance chromatin accessibility in the fed state.
Publications: 1 Organism: Homo Sapiens
+ KDM4Bdown-regulates activity img/direct_inhibition.png demethylation H3C1 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-263734 Lys10 RTKQTARkSTGGKAP Homo sapiens
pmid sentence
The KDM4 family of Jumonj domain histone demethylases specifically target di- and tri-methylated lysine 9 on histone H3 (H3K9me3), removing a modification central to defining heterochromatin and gene repression. The majority of studies regarding its function describe it as an activator that removes repressive H3K9me3 and H3K9me2 at or near regulated promoters in order to facilitate expression of the indicated pathways.
Publications: 1 Organism: Homo Sapiens
+ KDM4Cdown-regulates activity img/direct_inhibition.png demethylation H3C1 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-263865 Lys10 RTKQTARkSTGGKAP Homo sapiens
pmid sentence
As one member of the Jumonji-C histone demethylase family, JMJD2C has the ability to demethylate tri- or di-methylated histone 3 and 2 in either K9 (lysine residue 9) or K36 (lysine residue 36) sites by an oxidative reaction, thereby affecting heterochromatin formation, genomic imprinting, X-chromosome inactivation, and transcriptional regulation of genes.JMJD2C has been proved to be a demethylase for H3K9 methylation, in the manner of catalyzing the demethylation of H3K9me3/me2 (the known repressive markers of gene regulation), a histone mark found in heterochromatin associated with euchromatic transcriptional silencing and heterochromatin formation
Identifier Residue Sequence Organism Cell Line
SIGNOR-263864 Lys37 APATGGVkKPHRYRP Homo sapiens
pmid sentence
As one member of the Jumonji-C histone demethylase family, JMJD2C has the ability to demethylate tri- or di-methylated histone 3 and 2 in either K9 (lysine residue 9) or K36 (lysine residue 36) sites by an oxidative reaction, thereby affecting heterochromatin formation, genomic imprinting, X-chromosome inactivation, and transcriptional regulation of genes.JMJD2C has been proved to be a demethylase for H3K9 methylation, in the manner of catalyzing the demethylation of H3K9me3/me2 (the known repressive markers of gene regulation), a histone mark found in heterochromatin associated with euchromatic transcriptional silencing and heterochromatin formation
Publications: 2 Organism: Homo Sapiens
+ KAT2Bdown-regulates activity img/direct_inhibition.png acetylation H3C1 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-269611 Lys10 RTKQTARkSTGGKAP Homo sapiens
pmid sentence
The HAT module within the SAGA and ADA complexes acetylates histone H3, mainly on residues K9 and K14.
Identifier Residue Sequence Organism Cell Line
SIGNOR-269619 Lys15 ARKSTGGkAPRKQLA Homo sapiens
pmid sentence
The HAT module within the SAGA and ADA complexes acetylates histone H3, mainly on residues K9 and K14.
Publications: 2 Organism: Homo Sapiens
+ KDM3Bdown-regulates activity img/direct_inhibition.png demethylation H3C1 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-266634 Lys10 RTKQTARkSTGGKAP Chlorocebus aethiops
pmid sentence
We have purified a JmjC domain-containing protein, JHDM2A, which specifically demethylates mono- and dimethyl-H3K9. JHDM2A exhibits hormone-dependent recruitment to androgen-receptor target genes, resulting in H3K9 demethylation and transcriptional activation. Thus, our work identifies a histone demethylase and links its function to hormone-dependent transcriptional activation.
Publications: 1 Organism: Chlorocebus Aethiops
+ SAGA complexdown-regulates activity img/direct_inhibition.png acetylation H3C1 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-269628 Lys10 RTKQTARkSTGGKAP Homo sapiens
pmid sentence
The HAT module within the SAGA and ADA complexes acetylates histone H3, mainly on residues K9 and K14.
Identifier Residue Sequence Organism Cell Line
SIGNOR-269636 Lys15 ARKSTGGkAPRKQLA Homo sapiens
pmid sentence
The HAT module within the SAGA and ADA complexes acetylates histone H3, mainly on residues K9 and K14.
Publications: 2 Organism: Homo Sapiens
+ PHF2down-regulates activity img/direct_inhibition.png demethylation H3C1 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-264521 Lys10 RTKQTARkSTGGKAP Homo sapiens
pmid sentence
PHF2, a jmjC demethylase, is enzymatically inactive by itself, but becomes an active H3K9Me2 demethylase through PKA-mediated phosphorylation. This modification leads to targeting of the PHF2–ARID5B complex to its target promoters, where it removes the repressive H3K9Me2 mark.
Publications: 1 Organism: Homo Sapiens
+ SIRT7up-regulates activity img/direct-activation.png deacetylation H3C1 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-275874 Lys19 TGGKAPRkQLATKAA
pmid sentence
SIRT7 links H3K18 deacetylation to maintenance of oncogenic transformation.|Genome-wide binding studies reveal that SIRT7 binds to promoters of a specific set of gene targets, where it deacetylates H3K18Ac and promotes transcriptional repression.
Identifier Residue Sequence Organism Cell Line
SIGNOR-275880 Lys37 APATGGVkKPHRYRP
pmid sentence
Besides confirming the previously reported histone H3K18 deacylation activity, our results revealed that SIRT7 has an astonishingly high activity to catalyze deacylation of H3K36 and is also catalytically active to deacylate H3K37.
Identifier Residue Sequence Organism Cell Line
SIGNOR-275886 Lys38 PATGGVKkPHRYRPG
pmid sentence
Besides confirming the previously reported histone H3K18 deacylation activity, our results revealed that SIRT7 has an astonishingly high activity to catalyze deacylation of H3K36 and is also catalytically active to deacylate H3K37.
Publications: 3
+ Polycomb repressive complex 2up-regulates activity img/direct-activation.png methylation H3C1 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-260449 Lys28 LATKAARkSAPATGG Homo sapiens
pmid sentence
The presence of trimethylation of H3K27 (H3K27me3) at promoter regions is associated with gene repression. This modification is generated by the Polycomb repressive complex 2 (PRC2), composed of the SET domain-containing histone methyltransferase (HMT) EZH2 (enhancer of zeste homolog 2) or its functional homologue EZH1, and core accessory proteins (EED, SUZ12, and RbAp48) (Fig. 1A).
Publications: 1 Organism: Homo Sapiens
+ KDM6Adown-regulates activity img/direct_inhibition.png demethylation H3C1 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-260017 Lys28 LATKAARkSAPATGG Homo sapiens
pmid sentence
Ubiquitously Transcribed Tetratricopeptide Repeat on chromosome X (UTX) and Jumonji D3 (JMJD3) as novel histone demethylases that catalyze the removal of di- and trimethyl groups on histone H3 lysine 27, thereby promoting target gene activation.
Publications: 1 Organism: Homo Sapiens
+ KDM6Bdown-regulates activity img/direct_inhibition.png demethylation H3C1 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-260018 Lys28 LATKAARkSAPATGG Homo sapiens
pmid sentence
Ubiquitously Transcribed Tetratricopeptide Repeat on chromosome X (UTX) and Jumonji D3 (JMJD3) as novel histone demethylases that catalyze the removal of di- and trimethyl groups on histone H3 lysine 27, thereby promoting target gene activation.
Publications: 1 Organism: Homo Sapiens
+ SETD5up-regulates activity img/direct-activation.png methylation H3C1 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-264620 Lys37 APATGGVkKPHRYRP in vitro
pmid sentence
SETD5 Exhibits Intrinsic Methyltransferase Activity on H3K36. This assay showed that SETD5 has specific histone methyltransferase activity toward K36 but not for other residues such as K4 and K27 (Figure 8B). we revealed that SETD5 is endowed with H3K36 methyltransferase, which is necessary for RNA elongation and processing and, ultimately, correct gene transcription.
Publications: 1 Organism: In Vitro
+ SETD2up-regulates activity img/direct-activation.png trimethylation H3C1 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-269071 Lys37 APATGGVkKPHRYRP Homo sapiens
pmid sentence
Our results suggest that HYPB HMTase may coordinate histone methylation and transcriptional regulation in mammals and open perspective for the further study of the potential roles of HYPB protein in hematopoiesis and pathogenesis of HD.
Publications: 1 Organism: Homo Sapiens
+ ASH1Lup-regulates activity img/direct-activation.png trimethylation H3C1 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-269055 Lys37 APATGGVkKPHRYRP in vitro
pmid sentence
We show that human ASH1L specifically methylates histone H3 Lys-36. Our data implicate that there may be a regulatory mechanism of ASH1L histone methyltransferases
Publications: 1 Organism: In Vitro
+ KDM1Aup-regulates activity img/direct-activation.png demethylation H3C1 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-264507 Lys5 kQTARKST Homo sapiens HeLa Cell
pmid sentence
Here, we provide evidence that LSD1 (KIAA0601), a nuclear homolog of amine oxidases, functions as a histone demethylase and transcriptional corepressor. LSD1 specifically demethylates histone H3 lysine 4, which is linked to active transcription.
Publications: 1 Organism: Homo Sapiens
+ MLL1 complexdown-regulates activity img/direct_inhibition.png methylation H3C1 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-268801 Lys5 kQTARKST Homo sapiens
pmid sentence
Dimethylation of h3k4 requires a sub-complex including wrad (wdr5, rbbp5, ash2l, and dpy-30), which binds to each set1 family member forming a minimal corecomplexthat is required for multiple lysine methylation.
Publications: 1 Organism: Homo Sapiens
+ KDM5Bup-regulates activity img/direct-activation.png demethylation H3C1 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-264302 Lys5 kQTARKST Homo sapiens
pmid sentence
KDM5 subfamily is capable of removing tri‐ and di‐ methyl marks from lysine 4 on histone H3 (H3K4). Depending on the methylation site, its effect on transcription can be either activating or repressing.
Publications: 1 Organism: Homo Sapiens
+ MLL3 complexdown-regulates activity img/direct_inhibition.png methylation H3C1 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-268810 Lys5 kQTARKST Homo sapiens
pmid sentence
MLL3/KMT2C and MLL4/KMT2D are two paralogous histone modifiers that belong to the SET1/MLL (also named COMPASS) family of lysine methyltransferases and play critical roles in enhancer-regulated gene activation. MLL3 and MLL4 form identical multi-protein complexes for modifying mono-methylation of histone H3 lysine 4 (H3K4) at enhancers, which together with the p300/CBP-mediated H3K27 acetylation can generate an active enhancer landscape for long-range target gene activation.
Publications: 1 Organism: Homo Sapiens
+ PHF2up-regulates activity img/direct-activation.png demethylation H3C1 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-264516 Lys5 kQTARKST Homo sapiens HEK-293 Cell
pmid sentence
PHF2, a jmjC demethylase, is enzymatically inactive by itself, but becomes an active H3K9Me2 demethylase through PKA-mediated phosphorylation. This modification leads to targeting of the PHF2–ARID5B complex to its target promoters, where it removes the repressive H3K9Me2 mark.
Publications: 1 Organism: Homo Sapiens
+ MLL2 complexdown-regulates activity img/direct_inhibition.png methylation H3C1 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-268798 Lys5 kQTARKST Homo sapiens
pmid sentence
Dimethylation of h3k4 requires a sub-complex including wrad (wdr5, rbbp5, ash2l, and dpy-30), which binds to each set1 family member forming a minimal corecomplexthat is required for multiple lysine methylation.
Publications: 1 Organism: Homo Sapiens
+ SETD1Bdown-regulates activity img/direct_inhibition.png methylation H3C1 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-265576 Lys5 kQTARKST Homo sapiens
pmid sentence
SETD1B encodes a lysine-specific methyltransferase that assists in transcriptional activation of genes by depositing H3K4 methyl marks.
Publications: 1 Organism: Homo Sapiens
+ KDM5Cup-regulates activity img/direct-activation.png demethylation H3C1 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-264305 Lys5 kQTARKST Homo sapiens
pmid sentence
KDM5 subfamily is capable of removing tri‐ and di‐ methyl marks from lysine 4 on histone H3 (H3K4). Depending on the methylation site, its effect on transcription can be either activating or repressing.
Publications: 1 Organism: Homo Sapiens
+ Set1-Ash2 HMT complexdown-regulates activity img/direct_inhibition.png methylation H3C1 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-264482 Lys5 kQTARKST Homo sapiens HeLa Cell
pmid sentence
The Set1/Ash2 HMT methylates histone H3 at Lys 4 (K4), but not if the neighboring K9 residue is already methylated.
Publications: 1 Organism: Homo Sapiens
+ KDM5Aup-regulates activity img/direct-activation.png demethylation H3C1 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-264299 Lys5 kQTARKST Homo sapiens
pmid sentence
KDM5 subfamily is capable of removing tri‐ and di‐ methyl marks from lysine 4 on histone H3 (H3K4). Depending on the methylation site, its effect on transcription can be either activating or repressing.
Publications: 1 Organism: Homo Sapiens
+ KDM5Dup-regulates activity img/direct-activation.png demethylation H3C1 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-264308 Lys5 kQTARKST Homo sapiens
pmid sentence
KDM5 subfamily is capable of removing tri‐ and di‐ methyl marks from lysine 4 on histone H3 (H3K4). Depending on the methylation site, its effect on transcription can be either activating or repressing.
Publications: 1 Organism: Homo Sapiens
+ DOT1L img/unknown.png methylation H3C1 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-267141 Lys80 REIAQDFkTDLRFQS Homo sapiens
pmid sentence
HDOT1L Is a Nucleosomal H3-K79-Specific HMTase. We identified a human DOT1-like (DOT1L) protein and demonstrated that this protein possesses intrinsic H3-K79-specific histone methyltransferase (HMTase) activity in vitro and in vivo. Furthermore, we found that K79 methylation level is regulated throughout the cell cycle. By using two different methods, we demonstrate that the K79 methylation level decreases during S phase, reaches its lowest level in G2, increases during M phase, and maintains at a high level during G1 phase.
Publications: 1 Organism: Homo Sapiens
+ PIM1down-regulates activity img/direct_inhibition.png phosphorylation H3C1 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-156946 Ser11 TKQTARKsTGGKAPR Homo sapiens
pmid sentence
Pim1-dependent phosphorylation of histone h3 at serine 10 is required for myc-dependent transcriptional activation and oncogenic transformation.
Publications: 1 Organism: Homo Sapiens
+ AURKA img/unknown.png phosphorylation H3C1 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-118886 Ser11 TKQTARKsTGGKAPR Mus musculus
pmid sentence
In the present study, chromosome number instability and increased tumor invasiveness were noted in constitutively AIM-1-overexpressing cells in vivo. Increased mitotic Ser-10 phosphorylation was also observed in various colorectal tumor cells with high AIM-1 expression levels. These data suggest that increased H3 histone phosphorylation as a result of AIM-1 overexpression is a major precipitating factor of chromosome instability and, thus, may play a role in carcinogenesis.
Publications: 1 Organism: Mus Musculus
+ TGM2 img/unknown.png phosphorylation H3C1 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-143642 Ser11 TKQTARKsTGGKAPR Homo sapiens
pmid sentence
Tg2 is able to phosphorylate purified histone proteins, and h3 and h1 in chromatin preparations, and it is associated with chromatin in breast cancer cells.
Publications: 1 Organism: Homo Sapiens
+ TLK1up-regulates activity img/direct-activation.png phosphorylation H3C1 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-107037 Ser11 TKQTARKsTGGKAPR in vitro
pmid sentence
Purified tlk1b phosphorylated histone h3 at s(10) with high specificity both in a mix of core histones and in isolated chromatin, suggesting that histone h3 is a physiological substrate for tlk1b. Phosphorylation of H3 has been linked to the activation of the immediate-early genes upon mitogenic stimulation, and to chromatin condensation during mitotic/meiotic events.
Publications: 1 Organism: In Vitro
+ CDK8down-regulates activity img/direct_inhibition.png phosphorylation H3C1 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-273171 Ser11 TKQTARKsTGGKAPR
pmid sentence
However, within T/G-Mediator, cdk8 phosphorylates serine-10 on histone H3, which in turn stimulates H3K14 acetylation by GCN5L within the complex. Tandem phosphoacetylation of H3 correlates with transcriptional activation, and ChIP assays demonstrate co-occupancy of T/G-Mediator components at several activated genes in vivo.
Publications: 1
+ PAK1 img/unknown.png phosphorylation H3C1 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-91050 Ser11 TKQTARKsTGGKAPR Homo sapiens
pmid sentence
Histone h3 is a substrate of pak1 both in vitro and in vivo, and it specifically interacted with pak1 but not pak2 or pak3. Site-directed mutagenesis indicated that pak1 phosphorylates histone h3 on ser10.
Publications: 1 Organism: Homo Sapiens
+ AURKCup-regulates activity img/direct-activation.png phosphorylation H3C1 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-118898 Ser11 TKQTARKsTGGKAPR Homo sapiens
pmid sentence
Phosphorylation at ser-11 (h3s10ph) by aurkb is crucial for chromosome condensation and cell-cycle progression during mitosis and meiosis. Phosphorylation at ser-11 (h3s10ph) by aurkb is crucial for chromosome condensation and cell-cycle progression during mitosis and meiosis.
Identifier Residue Sequence Organism Cell Line
SIGNOR-98361 Ser11 TKQTARKsTGGKAPR Homo sapiens
pmid sentence
Phosphorylation at ser-11 (h3s10ph) by aurkb is crucial for chromosome condensation and cell-cycle progression during mitosis and meiosis. Phosphorylation at ser-11 (h3s10ph) by aurkb is crucial for chromosome condensation and cell-cycle progression during mitosis and meiosis.
Publications: 2 Organism: Homo Sapiens
+ RPS6KA5down-regulates activity img/direct_inhibition.png phosphorylation H3C1 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-70444 Ser11 TKQTARKsTGGKAPR Homo sapiens
pmid sentence
Phosphorylation at ser-11 (h3s10ph) by rps6ka4 and rps6ka5 is important during interphase because it enables the transcription of genes following external stimulation, like mitogens, stress, growth factors or uv irradiation and result in the activation of genes, such as c-fos and c-jun.
Identifier Residue Sequence Organism Cell Line
SIGNOR-138483 Ser11 TKQTARKsTGGKAPR Homo sapiens
pmid sentence
Phosphorylation at ser-11 (h3s10ph) by rps6ka4 and rps6ka5 is important during interphase because it enables the transcription of genes following external stimulation, like mitogens, stress, growth factors or uv irradiation and result in the activation of genes, such as c-fos and c-jun.
Identifier Residue Sequence Organism Cell Line
SIGNOR-119237 Ser11 TKQTARKsTGGKAPR Homo sapiens
pmid sentence
Phosphorylation at ser-11 (h3s10ph) by rps6ka4 and rps6ka5 is important during interphase because it enables the transcription of genes following external stimulation, like mitogens, stress, growth factors or uv irradiation and result in the activation of genes, such as c-fos and c-jun.
Identifier Residue Sequence Organism Cell Line
SIGNOR-163712 Ser29 ATKAARKsAPATGGV Homo sapiens
pmid sentence
Upon activation of the erk and p38 mapk pathways, the msk1/2-mediated nucleosomal response, including h3 phosphorylation at serine 28 or 10, is coupled with the induction of immediate-early (ie) gene transcription.
Publications: 4 Organism: Homo Sapiens
+ AURKBup-regulates activity img/direct-activation.png phosphorylation H3C1 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-118894 Ser11 TKQTARKsTGGKAPR Homo sapiens
pmid sentence
Phosphorylation at ser-11 (h3s10ph) by aurkb is crucial for chromosome condensation and cell-cycle progression during mitosis and meiosis. Phosphorylation at ser-11 (h3s10ph) by aurkb is crucial for chromosome condensation and cell-cycle progression during mitosis and meiosis.
Identifier Residue Sequence Organism Cell Line
SIGNOR-98297 Ser11 TKQTARKsTGGKAPR Homo sapiens
pmid sentence
Phosphorylation at ser-11 (h3s10ph) by aurkb is crucial for chromosome condensation and cell-cycle progression during mitosis and meiosis. Phosphorylation at ser-11 (h3s10ph) by aurkb is crucial for chromosome condensation and cell-cycle progression during mitosis and meiosis.
Publications: 2 Organism: Homo Sapiens
+ RPS6KA3down-regulates activity img/direct_inhibition.png phosphorylation H3C1 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-119229 Ser11 TKQTARKsTGGKAPR Homo sapiens
pmid sentence
Phosphorylation at ser-11 (h3s10ph) by rps6ka4 and rps6ka5 is important during interphase because it enables the transcription of genes following external stimulation, like mitogens, stress, growth factors or uv irradiation and result in the activation of genes, such as c-fos and c-jun.
Identifier Residue Sequence Organism Cell Line
SIGNOR-70436 Ser11 TKQTARKsTGGKAPR Homo sapiens
pmid sentence
Phosphorylation at ser-11 (h3s10ph) by rps6ka4 and rps6ka5 is important during interphase because it enables the transcription of genes following external stimulation, like mitogens, stress, growth factors or uv irradiation and result in the activation of genes, such as c-fos and c-jun.
Identifier Residue Sequence Organism Cell Line
SIGNOR-138475 Ser11 TKQTARKsTGGKAPR Homo sapiens
pmid sentence
Phosphorylation at ser-11 (h3s10ph) by rps6ka4 and rps6ka5 is important during interphase because it enables the transcription of genes following external stimulation, like mitogens, stress, growth factors or uv irradiation and result in the activation of genes, such as c-fos and c-jun.
Publications: 3 Organism: Homo Sapiens
+ CKM complexdown-regulates activity img/direct_inhibition.png phosphorylation H3C1 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-273170 Ser11 TKQTARKsTGGKAPR
pmid sentence
However, within T/G-Mediator, cdk8 phosphorylates serine-10 on histone H3, which in turn stimulates H3K14 acetylation by GCN5L within the complex. Tandem phosphoacetylation of H3 correlates with transcriptional activation, and ChIP assays demonstrate co-occupancy of T/G-Mediator components at several activated genes in vivo.
Publications: 1
+ VRK1 img/unknown.png phosphorylation H3C1 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-158436 Ser11 TKQTARKsTGGKAPR Homo sapiens
pmid sentence
We show that histone h3 is phosphorylated by vaccinia-related kinase 1 (vrk1). Direct phosphorylation of thr3 and ser10 in h3 by vrk1 both in vitro and in vivo was observed. Loss of vrk1 activity was associated with a marked decrease in h3 phosphorylation during mitosis.
Publications: 1 Organism: Homo Sapiens
+ AURKAup-regulates activity img/direct-activation.png phosphorylation H3C1 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-98289 Ser11 TKQTARKsTGGKAPR Homo sapiens
pmid sentence
Phosphorylation at ser-11 (h3s10ph) by aurkb is crucial for chromosome condensation and cell-cycle progression during mitosis and meiosis. Phosphorylation at ser-11 (h3s10ph) by aurkb is crucial for chromosome condensation and cell-cycle progression during mitosis and meiosis.
Publications: 1 Organism: Homo Sapiens
+ PBK img/unknown.png phosphorylation H3C1 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-149716 Ser11 TKQTARKsTGGKAPR Homo sapiens
pmid sentence
Pbk/topk could phosphorylate histone h3 at ser10 in vitro and in vivo, and mediated its growth-promoting effect through histone h3 modification.
Publications: 1 Organism: Homo Sapiens
+ MAPK14 img/unknown.png phosphorylation H3C1 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-166602 Ser11 TKQTARKsTGGKAPR Homo sapiens
pmid sentence
The p38 mapk pathway can positevely regulate nf-kb activity by different mechanisms, including chromatin remodelling through ser10 phosphorylation of histone h3 at nf-kb dependent promoters such as il-8 and mcp or by impinging on ikk or the p65 subunit in a direct or indirect manner.
Publications: 1 Organism: Homo Sapiens
+ PIMdown-regulates activity img/direct_inhibition.png phosphorylation H3C1 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-259409 Ser11 TKQTARKsTGGKAPR Homo sapiens
pmid sentence
Pim1-dependent phosphorylation of histone h3 at serine 10 is required for myc-dependent transcriptional activation and oncogenic transformation.
Publications: 1 Organism: Homo Sapiens
+ AURKBdown-regulates activity img/direct_inhibition.png phosphorylation H3C1 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-114852 Ser29 ATKAARKsAPATGGV Homo sapiens
pmid sentence
Histone code pathway involving h3 s28 phosphorylation and k27 acetylation activates transcription and antagonizes polycomb silencingaurora-b phosphorylates histone h3 at serine28 with regard to the mitotic chromosome condensation
Identifier Residue Sequence Organism Cell Line
SIGNOR-171717 Ser29 ATKAARKsAPATGGV Homo sapiens
pmid sentence
Histone code pathway involving h3 s28 phosphorylation and k27 acetylation activates transcription and antagonizes polycomb silencingaurora-b phosphorylates histone h3 at serine28 with regard to the mitotic chromosome condensation
Publications: 2 Organism: Homo Sapiens
+ HASPINup-regulates activity img/direct-activation.png phosphorylation H3C1 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-275418 Thr3 T-->R Homo sapiens
pmid sentence
Here we show that phosphorylation of histone H3 threonine 3 (H3T3ph) by Haspin is necessary for CPC accumulation at centromeres and that the CPC subunit Survivin binds directly to H3T3ph.
Identifier Residue Sequence Organism Cell Line
SIGNOR-275428 Thr4 tKQTARKS Homo sapiens
pmid sentence
Here we show that phosphorylation of histone H3 threonine 3 (H3T3ph) by Haspin is necessary for CPC accumulation at centromeres and that the CPC subunit Survivin binds directly to H3T3ph.
Publications: 2 Organism: Homo Sapiens
+ PRKCDup-regulates activity img/direct-activation.png phosphorylation H3C1 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-185144 Thr46 PHRYRPGtVALREIR Homo sapiens
pmid sentence
We identify protein kinase c-delta as the kinase responsible for h3t45ph in vitro and in vivo. Given the nucleosomal position of h3t45, we postulate that h3t45ph induces structural change within the nucleosome to facilitate dna nicking and/or fragmentation.
Publications: 1 Organism: Homo Sapiens
+ CBX3up-regulates activity img/direct-activation.png binding H3C1 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-264496 Homo sapiens
pmid sentence
A core characteristic of heterochromatin is its association with heterochromatin protein 1 (HP1) proteins, a highly conserved family of chromosomal proteins that bind to di- and trimethylated H3K9 via a conserved N-terminal domain called the chromodomain (CD) HP1 proteins are a highly conserved family of eukaryotic proteins that bind to methylated histone H3 lysine 9 (H3K9) and are required for heterochromatic gene silencing.
Publications: 1 Organism: Homo Sapiens
+ CTNNB1up-regulates activity img/indirect-activation.png H3C1 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-260448 Homo sapiens
pmid sentence
Beta-cat promotes h3k4 trimethylation at the c-myc gene in vivo. H3k4 trimethylation in vivo requires prior ubiquitination of h2b, and we find that ubiquitin is necessary for transcription initiation on chromatin but not nonchromatin templates in vitro. Chromatin immunoprecipitation experiments reveal that beta-cat recruits pygopus, bcl-9/legless, and mll/set1-type complexes to the c-myc enhancertogether with the negative wnt regulators, apc, and betatrcp.
Publications: 1 Organism: Homo Sapiens
+ BAZ2Bdown-regulates activity img/direct_inhibition.png binding H3C1 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-266622 Homo sapiens
pmid sentence
The BAZ2B bromodomain has been shown to bind to acetylated H3K14 (H3K14ac), whose presence at promoter regions is generally associated with gene activation. This suggests a potential role for BAZ2B in transcriptional activation.
Publications: 1 Organism: Homo Sapiens
+ H3C1form complex img/form-complex.png binding Nucleosome_H2A.Z.2 variant 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-263711 in vitro
pmid sentence
In the nucleosome, two of each of the histones H2A, H2B, H3 and H4 form the histone octamer and about 145–147 base pairs of DNA are wrapped around it . The histone H2A.Z variant is widely conserved among eukaryotes. Two isoforms, H2A.Z.1 and H2A.Z.2, have been identified in vertebrates and may have distinct functions in cell growth and gene expression. However, no structural differences between H2A.Z.1 and H2A.Z.2 have been reported. In the present study, the crystal structures of nucleosomes containing human H2A.Z.1 and H2A.Z.2 were determined.
Publications: 1 Organism: In Vitro
+ CBX1up-regulates activity img/direct-activation.png binding H3C1 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-264493 Homo sapiens
pmid sentence
A core characteristic of heterochromatin is its association with heterochromatin protein 1 (HP1) proteins, a highly conserved family of chromosomal proteins that bind to di- and trimethylated H3K9 via a conserved N-terminal domain called the chromodomain (CD) HP1 proteins are a highly conserved family of eukaryotic proteins that bind to methylated histone H3 lysine 9 (H3K9) and are required for heterochromatic gene silencing.
Publications: 1 Organism: Homo Sapiens
+ H3C1up-regulates quantity img/direct-activation.png binding CPC 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-275422 Homo sapiens HeLa Cell
pmid sentence
Histone modifications coordinate the chromatin localization of key regulatory factors in mitosis. For example, mitotic phosphorylation of Histone H3 threonine-3 (H3T3ph) by Haspin creates a binding site for the chromosomal passenger complex (CPC).
Publications: 1 Organism: Homo Sapiens
+ MAML1down-regulates activity img/direct_inhibition.png acetylation H3C1 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-153038 Homo sapiens
pmid sentence
The n-terminal domain of maml1 directly interacts with both p300 and histones, and the p300-maml1 complex specifically acetylates histone h3 and h4 tails in chromatin.
Publications: 1 Organism: Homo Sapiens
+ H3C1form complex img/form-complex.png binding Nucleosome_H3.1 variant 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-263721 in vitro
pmid sentence
The elemental repeating unit of chromatin is the nucleosome core particle (NCP), which consists of 146 base pairs of DNA wrapped in 1.65 left-handed superhelical turns around the histone octamer. The histone octamer comprises two each of the core histones, H2A, H2B, H3 and H4, which form two H2A/H2B dimers and an H3/H4 tetramer, respectively, in the NCP.
Publications: 1 Organism: In Vitro
+ H3C1up-regulates activity img/indirect-activation.png Transcritpional_activation 0.7
Identifier Residue Sequence Organism Cell Line
SIGNOR-269072 Homo sapiens
pmid sentence
Widely described to be associated with active chromatin, H3K36 methylation has also been implicated in transcriptional repression, alternative splicing, dosage compensation, DNA replication and repair
Publications: 1 Organism: Homo Sapiens
+ Sin3B_complexdown-regulates activity img/direct_inhibition.png binding H3C1 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-266973 Homo sapiens
pmid sentence
We report here the identification of a mammalian complex containing the corepressor Sin3B, the histone deacetylase HDAC1, Mrg15, and the PHD finger-containing Pf1 and show that this complex plays important roles in regulation of transcription. Sin3B, Pf1, Mrg15, and HDAC1 associate within a stable complex that binds H3K4me3/H3K36me3-enriched nucleosomes. We identify mammalian Pf1, a PHD finger protein, as a homologue of Rco1, and show that all four components, Sin3B, HDAC1, Mrg15, and Pf1, can form a stable complex, which is recruited downstream of the transcriptional start site through complex interactions with histones. these results indicate that the Pf1/Sin3B-containing complex is recruited at discrete sites within actively transcribed loci, likely through its interaction with H3K4me3/H3K36me3-enriched chromatin.
Publications: 1 Organism: Homo Sapiens
+ CBX5up-regulates activity img/direct-activation.png binding H3C1 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-264490 Homo sapiens
pmid sentence
A core characteristic of heterochromatin is its association with heterochromatin protein 1 (HP1) proteins, a highly conserved family of chromosomal proteins that bind to di- and trimethylated H3K9 via a conserved N-terminal domain called the chromodomain (CD) HP1 proteins are a highly conserved family of eukaryotic proteins that bind to methylated histone H3 lysine 9 (H3K9) and are required for heterochromatic gene silencing.
Publications: 1 Organism: Homo Sapiens
+ SLBPup-regulates quantity by expression img/direct-activation.png translation regulation H3C1 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-265413 Homo sapiens U2-OS Cell
pmid sentence
Synthesis of mature histone mRNA requires only a single processing reaction: an endonucleolytic cleavage between a conserved stem-loop and a purine-rich downstream element to form the 3' end. The stem-loop binding protein (SLBP) is required for processing, and following processing, histone mRNA is transported to the cytoplasm, where SLBP participates in translation of the histone mRNA|We used radiolabeled probes generated by PCR targeting the open reading frame (ORF) to detect histones H2A, H2B, H3, H4, and H1 and used 7SK snRNA as a loading control (Fig. 2A). The abundance of histone H2A, H2B, H3, and H4 mRNAs is reduced to 37% to 70% of control levels in the SLBP knockdown cells when compared to the C2 control.
Publications: 1 Organism: Homo Sapiens
+ H3C1form complex img/form-complex.png binding Nucleosome_H2A.Z.1 variant 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-263717 in vitro
pmid sentence
In the nucleosome, two of each of the histones H2A, H2B, H3 and H4 form the histone octamer and about 145–147 base pairs of DNA are wrapped around it . The histone H2A.Z variant is widely conserved among eukaryotes. Two isoforms, H2A.Z.1 and H2A.Z.2, have been identified in vertebrates and may have distinct functions in cell growth and gene expression. However, no structural differences between H2A.Z.1 and H2A.Z.2 have been reported. In the present study, the crystal structures of nucleosomes containing human H2A.Z.1 and H2A.Z.2 were determined.
Publications: 1 Organism: In Vitro
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