Relation Results

Summary

Name PHIP
Full Name PH-interacting protein
Synonyms PHIP, IRS-1 PH domain-binding protein, WD repeat-containing protein 11 | WDR11
Primary ID Q8WWQ0
Links - -
Type protein
Relations 2
Function Probable regulator of the insulin and insulin-like growth factor signaling pathways. Stimulates cell proliferation through regulation of cyclin transc ...
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Type: Score: Layout: SPV 
0.3290.517PHIPCullin4-RBX1-DDB1IRS1

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Relations
Regulator
Mechanism
target
score ℹ
+ PHIPup-regulates activity img/direct-activation.png binding Cullin4-RBX1-DDB1 0.329
Identifier Residue Sequence Organism Cell Line
SIGNOR-266963 Homo sapiens K-562 Cell
pmid sentence
One member of the CRL4 complex, the WD-40 containing protein RepID (DCAF14/PHIP), selectively binds and activates a group of replication origins. Here we show that RepID recruits the CRL4 complex to chromatin prior to DNA synthesis, thus playing a crucial architectural role in the proper licensing of chromosomes for replication. In the absence of RepID, cells rely on the alternative ubiquitin ligase, SKP2-containing SCF, to progress through the cell cycle.
Publications: 1 Organism: Homo Sapiens
+ PHIPup-regulates activity img/direct-activation.png binding IRS1 0.517
Identifier Residue Sequence Organism Cell Line
SIGNOR-266962 Chlorocebus aethiops COS-1 Cell
pmid sentence
We have recently reported the isolation of a PH domain-interacting protein, PHIP, which selectively binds to the IRS-1 PH domain and is stably associated with IRS-1 in mammalian cells. Here we demonstrate that overexpression of PHIP in fibroblasts enhances insulin-induced transcriptional responses in a mitogen-activated protein kinase-dependent manner.
Publications: 1 Organism: Chlorocebus Aethiops
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