+ |
PHIP | up-regulates activity
binding
|
Cullin4-RBX1-DDB1 |
0.333 |
Identifier |
Residue |
Sequence |
Organism |
Cell Line |
SIGNOR-266963 |
|
|
Homo sapiens |
K-562 Cell |
pmid |
sentence |
30018425 |
One member of the CRL4 complex, the WD-40 containing protein RepID (DCAF14/PHIP), selectively binds and activates a group of replication origins. Here we show that RepID recruits the CRL4 complex to chromatin prior to DNA synthesis, thus playing a crucial architectural role in the proper licensing of chromosomes for replication. In the absence of RepID, cells rely on the alternative ubiquitin ligase, SKP2-containing SCF, to progress through the cell cycle. |
|
Publications: |
1 |
Organism: |
Homo Sapiens |
+ |
PHIP | up-regulates activity
binding
|
IRS1 |
0.527 |
Identifier |
Residue |
Sequence |
Organism |
Cell Line |
SIGNOR-266962 |
|
|
Chlorocebus aethiops |
COS-1 Cell |
pmid |
sentence |
12242307 |
We have recently reported the isolation of a PH domain-interacting protein, PHIP, which selectively binds to the IRS-1 PH domain and is stably associated with IRS-1 in mammalian cells. Here we demonstrate that overexpression of PHIP in fibroblasts enhances insulin-induced transcriptional responses in a mitogen-activated protein kinase-dependent manner. |
|
Publications: |
1 |
Organism: |
Chlorocebus Aethiops |