Summary

Name IRS1
Full Name Insulin receptor substrate 1
Synonyms IRS-1
Primary ID P35568
Links - -
Type protein
Relations 128
Pathways Adipogenesis, AMPK Signaling, Insulin Signaling, Luminal Breast Cancer, Leptin Signaling, mTOR in cancer, MTOR Signaling, Myofiber: IGF1R, Satellite: IGF1, Satellite: IGF1R, Satellite: miRNA network
Function May mediate the control of various cellular processes by insulin. When phosphorylated by the insulin receptor binds specifically to various cellular proteins containing SH2 domains such as phosphatidylinositol 3-kinase p85 subunit or GRB2. Activates phosphatidylinositol 3-kinase when bound to the regulatory p85 subunit (By similarity).

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Modifications Tables

Relations

Regulator Mechanism target score
+ down-regulates quantity by destabilization img/direct_inhibition.png phosphorylation IRS1 0.2
Publications: 3 Organism: Homo Sapiens
Tissue: Ovary
+ down-regulates activity img/direct_inhibition.png phosphorylation IRS1 0.629
Publications: 2 Organism: Cricetulus Griseus, Homo Sapiens
+ down-regulates activity img/direct_inhibition.png phosphorylation IRS1 0.782
Publications: 6 Organism: Mus Musculus, Homo Sapiens
Tissue: Ovary, Myotube, Brain
Pathways:Insulin Signaling, MTOR Signaling
+ down-regulates quantity by destabilization img/direct_inhibition.png phosphorylation IRS1 0.716
Publications: 1 Organism: Homo Sapiens
Tissue: Ovary
+ down-regulates activity img/direct_inhibition.png phosphorylation IRS1 0.549
Publications: 1 Organism: Mus Musculus
+ img/unknown.png phosphorylation IRS1 0.324
Publications: 6 Organism: In Vitro
+ img/unknown.png phosphorylation IRS1 0.345
Publications: 6 Organism: In Vitro
+ down-regulates activity img/direct_inhibition.png phosphorylation IRS1 0.401
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png phosphorylation IRS1 0.273
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png phosphorylation IRS1 0.642
Publications: 10 Organism: In Vitro
+ down-regulates activity img/direct_inhibition.png phosphorylation IRS1 0.758
Publications: 7 Organism: Rattus Norvegicus, Homo Sapiens
Tissue: Kidney
Pathways:Leptin Signaling, MTOR Signaling
+ down-regulates activity img/direct_inhibition.png phosphorylation IRS1 0.716
Publications: 1 Organism: Cricetulus Griseus
+ down-regulates img/direct_inhibition.png phosphorylation IRS1 0.768
Publications: 5 Organism: Homo Sapiens
Tissue: Muscle, Skeletal Muscle
+ down-regulates img/direct_inhibition.png phosphorylation IRS1 0.364
Publications: 1 Organism: Homo Sapiens
Tissue: Muscle
+ down-regulates img/direct_inhibition.png phosphorylation IRS1 0.2
Publications: 1 Organism: Homo Sapiens
Tissue: Muscle
Pathways:Adipogenesis, Insulin Signaling, Luminal Breast Cancer
+ down-regulates img/direct_inhibition.png phosphorylation IRS1 0.697
Publications: 4 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png phosphorylation IRS1 0.383
Publications: 1 Organism: Homo Sapiens
Tissue: Ovary
+ down-regulates quantity by destabilization img/direct_inhibition.png phosphorylation IRS1 0.2
Publications: 1 Organism: Rattus Norvegicus
+ down-regulates img/direct_inhibition.png phosphorylation IRS1 0.666
Publications: 1 Organism: Homo Sapiens
+ down-regulates quantity by destabilization img/direct_inhibition.png phosphorylation IRS1 0.768
Publications: 1 Organism: Rattus Norvegicus
+ down-regulates img/direct_inhibition.png phosphorylation IRS1 0.716
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png phosphorylation IRS1 0.629
Publications: 2 Organism: Homo Sapiens
Tissue: Muscle, Skeletal Muscle, Kidney
+ down-regulates quantity by destabilization img/direct_inhibition.png phosphorylation IRS1 0.782
Publications: 2 Organism: Mus Musculus
Pathways:Insulin Signaling, MTOR Signaling
+ down-regulates activity img/direct_inhibition.png phosphorylation IRS1 0.666
Publications: 2 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png phosphorylation IRS1 0.695
Publications: 2 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png phosphorylation IRS1 0.768
Publications: 2 Organism: Homo Sapiens
+ down-regulates quantity img/direct_inhibition.png phosphorylation IRS1 0.592
Publications: 1
+ img/unknown.png phosphorylation IRS1 0.592
Publications: 2 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png dephosphorylation IRS1 0.892
Publications: 4 Organism: Homo Sapiens
Pathways:Leptin Signaling
+ up-regulates img/direct-activation.png phosphorylation IRS1 0.864
Publications: 10 Organism: Homo Sapiens
Tissue: Skeletal Muscle
Pathways:IGF and Myogenesis
+ up-regulates activity img/direct-activation.png phosphorylation IRS1 0.911
Publications: 11 Organism: Homo Sapiens, Cricetulus Griseus, Rattus Norvegicus
Pathways:Adipogenesis, AMPK Signaling, Insulin Signaling, Luminal Breast Cancer, Leptin Signaling, mTOR in cancer, MTOR Signaling
+ down-regulates img/indirect_inhibition.png IRS1 0.629
Publications: 1 Organism: Homo Sapiens
Tissue: Kidney
+ down-regulates activity img/indirect_inhibition.png IRS1 0.671
Publications: 1 Organism: Rattus Norvegicus
Pathways:Adipogenesis, AMPK Signaling, Insulin Signaling, Luminal Breast Cancer, Leptin Signaling, mTOR in cancer, MTOR Signaling
+ up-regulates img/indirect-activation.png IRS1 0.8
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/indirect_inhibition.png IRS1 0.709
Publications: 1 Organism: Homo Sapiens
Pathways:AMPK Signaling, Luminal Breast Cancer, mTOR in cancer, MTOR Signaling, IGF and Myogenesis
+ up-regulates activity img/direct-activation.png isomerization IRS1 0.2
Publications: 1 Organism: Homo Sapiens
+ down-regulates quantity by destabilization img/direct_inhibition.png binding IRS1 0.476
Publications: 1 Organism: Mus Musculus
+ down-regulates quantity by destabilization img/direct_inhibition.png phosphorylation IRS1 0.37
Publications: 1 Organism: Homo Sapiens
Tissue: Skeletal Muscle
Pathways:AMPK Signaling, MTOR Signaling
+ up-regulates activity img/direct-activation.png binding PI3K 0.757
Publications: 3 Organism: Rattus Norvegicus, Homo Sapiens
Tissue: Skeletal Muscle, Lung Cancer Cell
Pathways:Leptin Signaling, mTOR in cancer
+ down-regulates img/indirect_inhibition.png IRS1 0.411
Publications: 1 Organism: Homo Sapiens
Pathways:MTOR Signaling
+ up-regulates img/direct-activation.png phosphorylation IRS1 0.542
Publications: 1 Organism: Homo Sapiens
Tissue: Muscle, Lung, Smooth Muscle
+ down-regulates activity img/direct_inhibition.png phosphorylation IRS1 0.2
Publications: 1 Organism: Homo Sapiens
Pathways:Adipogenesis, AMPK Signaling, Insulin Signaling, Luminal Breast Cancer, Leptin Signaling, MTOR Signaling
+ up-regulates activity img/direct-activation.png isomerization IRS1 0.2
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png binding IRS1 0.73
Publications: 1 Organism: Homo Sapiens
Pathways:Leptin Signaling
+ up-regulates activity img/direct-activation.png binding PIK3R1 0.806
Publications: 1 Organism: Rattus Norvegicus
Tissue: Skeletal Muscle
Pathways:MTOR Signaling, IGF and Myogenesis
+ down-regulates img/direct_inhibition.png dephosphorylation IRS1 0.771
Publications: 1 Organism: In Vitro
Pathways:Insulin Signaling
+ down-regulates quantity by destabilization img/indirect_inhibition.png IRS1 0.671
Publications: 1 Organism: Homo Sapiens
Pathways:Adipogenesis, AMPK Signaling, Insulin Signaling, Luminal Breast Cancer, Leptin Signaling, mTOR in cancer, MTOR Signaling
+ down-regulates activity img/direct_inhibition.png phosphorylation IRS1 0.2
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png binding GRB2 0.796
Publications: 1 Organism: Homo Sapiens
Pathways:Adipogenesis, Insulin Signaling, Luminal Breast Cancer
+ up-regulates activity img/direct-activation.png binding PIK3CB 0.71
Publications: 2 Organism: Mus Musculus
Tissue: Muscle
Pathways:Adipogenesis, Insulin Signaling
+ down-regulates quantity by destabilization img/direct_inhibition.png polyubiquitination IRS1 0.355
Publications: 1 Organism: Mus Musculus
+ down-regulates quantity by destabilization img/direct_inhibition.png phosphorylation IRS1 0.2
Publications: 1 Organism: Homo Sapiens
Tissue: Skeletal Muscle
Pathways:Leptin Signaling
+ up-regulates activity img/direct-activation.png binding IRS1 0.531
Publications: 1 Organism: Chlorocebus Aethiops
+ up-regulates activity img/direct-activation.png phosphorylation IRS1 0.695
Publications: 1 Organism: Mus Musculus
+ down-regulates activity img/indirect_inhibition.png IRS1 0.757
Publications: 1 Organism: Homo Sapiens
Pathways:Leptin Signaling, mTOR in cancer
+ up-regulates img/direct-activation.png phosphorylation IRS1 0.321
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png binding PIK3CA 0.709
Publications: 1 Organism: Homo Sapiens
Pathways:AMPK Signaling, Luminal Breast Cancer, mTOR in cancer, MTOR Signaling, IGF and Myogenesis