Summary

Name RASSF5
Full Name Ras association domain-containing protein 5
Synonyms New ras effector 1, Regulator for cell adhesion and polarization enriched in lymphoid tissues, RAPL | NORE1, RAPL
Primary ID Q8WWW0
Links - -
Type protein
Relations 2
Function Potential tumor suppressor. Seems to be involved in lymphocyte adhesion by linking RAP1A activation upon T-cell receptor or chemokine stimulation to integrin activation. Isoform 2 stimulates lymphocyte polarization and the patch-like distribution of ITGAL/LFA-1, resulting in an enhanced adhesion to ICAM1. Together with RAP1A may participate in regulation of microtubule growth. The association of isoform 2 with activated RAP1A is required for directional movement of endothelial cells during wound healing. May be involved in regulation of Ras apoptotic function. The RASSF5-STK4/MST1 complex may mediate HRAS and KRAS induced apoptosis.

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Relations

Regulator Mechanism target score
+ up-regulates activity img/direct-activation.png binding KRAS 0.68
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png binding RASSF1 0.521
Publications: 1 Organism: Homo Sapiens