3.0
Summary
| Name |  RASSF5
|
| Full Name | Ras association domain-containing protein 5 |
| Synonyms | New ras effector 1, Regulator for cell adhesion and polarization enriched in lymphoid tissues, RAPL | NORE1, RAPL |
| Primary ID | Q8WWW0 |
| Links |  -  -  |
| Type | protein |
| Relations | 2 |
| Function | Potential tumor suppressor. Seems to be involved in lymphocyte adhesion by linking RAP1A activation upon T-cell receptor or chemokine stimulation to integrin activation. Isoform 2 stimulates lymphocyte polarization and the patch-like distribution of ITGAL/LFA-1, resulting in an enhanced adhesion to ICAM1. Together with RAP1A may participate in regulation of microtubule growth. The association of isoform 2 with activated RAP1A is required for directional movement of endothelial cells during wound healing. May be involved in regulation of Ras apoptotic function. The RASSF5-STK4/MST1 complex may mediate HRAS and KRAS induced apoptosis. |
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