4.0
Summary
| Name |  RASSF1View Modifications |
| Full Name | Ras association domain-containing protein 1 |
| Synonyms | RASF1_HUMAN | RDA32 |
| Primary ID | Q9NS23 |
| Links |  -  -  |
| Type | protein |
| Relations | 19 |
| Pathways | Non-small-cell lung cancer (NSCLC) |
| Function | Potential tumor suppressor. Required for death receptor-dependent apoptosis. Mediates activation of STK3/MST2 and STK4/MST1 during Fas-induced apoptosis by preventing their dephosphorylation. When associated with MOAP1, promotes BAX conformational change and translocation to mitochondrial membranes in response to TNF and TNFSF10 stimulation. Isoform A interacts with CDC20, an activator of the anaphase-promoting complex, APC, resulting in the inhibition of APC activity and mitotic progression. Inhibits proliferation by negatively regulating cell cycle progression at the level of G1/S-phase transition by regulating accumulation of cyclin D1 protein. Isoform C has been shown not to perform these roles, no function has been identified for this isoform. Isoform A disrupts interactions among MDM2, DAXX and USP7, thus contributing to the efficient activation of TP53 by promoting MDM2 self-ubiquitination in cell-cycle checkpoint control in response to DNA damage. |
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Modifications Tables
Relations
| Regulator | Mechanism | target | score ℹ | |
|---|---|---|---|---|
| + | ATM | up-regulates 
phosphorylation
|
RASSF1 | 0.549 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | CHEK1 |
phosphorylation
|
RASSF1 | 0.353 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | CyclinD/CDK4 | down-regulates 
phosphorylation
|
RASSF1 | 0.492 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | CDK4 | down-regulates
phosphorylation
|
RASSF1 | 0.409 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | AURKA | down-regulates
phosphorylation
|
RASSF1 | 0.448 |
| Publications: | 2 | Organism: | Homo Sapiens | |
| + | AURKB | down-regulates
phosphorylation
|
RASSF1 | 0.438 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | KRAS | up-regulates activity
binding
|
RASSF1 | 0.65 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| Pathways: | Non-small-cell lung cancer (NSCLC) | |||
| + | RASSF1 | down-regulates quantity by repression 
post transcriptional regulation
|
CCND1 | 0.576 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | RASSF5 | up-regulates activity
binding
|
RASSF1 | 0.543 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | RASSF1 | up-regulates
binding
|
STK4 | 0.805 |
| Publications: | 2 | Organism: | Homo Sapiens | |
| Pathways: | Hippo Signaling | |||
| + | FAS | up-regulates 
|
RASSF1 | 0.257 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | 14-3-3 | down-regulates
binding
|
RASSF1 | 0.2 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| Pathways: | Hippo Signaling | |||
| + | MOAP1 | up-regulates activity
binding
|
RASSF1 | 0.573 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | RASSF1 | up-regulates
binding
|
STK3/4 | 0.805 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| Pathways: | Hippo Signaling | |||
| + | CNKSR1 | up-regulates
binding
|
RASSF1 | 0.402 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | RASSF1 | up-regulates
binding
|
STK3 | 0.696 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| Pathways: | Hippo Signaling | |||
| + | RASSF1 | up-regulates activity
binding
|
STK3 | 0.696 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| Pathways: | Hippo Signaling | |||