LIPH, LPD lipase-related protein, Membrane-associated phosphatidic acid-selective phospholipase A1-alpha, mPA-PLA1 alpha, Phospholipase A1 member B | LPDLR, MPAPLA1, PLA1B
Primary ID
Q8WWY8
Links
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Type
protein
Relations
1
Function
Hydrolyzes specifically phosphatidic acid (PA) to produce 2-acyl lysophosphatidic acid (LPA; a potent bioactive lipid mediator) and fatty acid. Does not hydrolyze other phospholipids, like phosphatidylserine (PS), phosphatidylcholine (PC) and phosphatidylethanolamine (PE) or triacylglycerol (TG).
When overexpressed in jurkat t cells, the edg4 protein mediated lpa-induced activation of a serum response element reporter gene with lpa concentration dependence (ec50 of 10 nm) and specificity.