Summary

Name DDB2
Full Name DNA damage-binding protein 2
Synonyms DDB p48 subunit, DDBb, Damage-specific DNA-binding protein 2, UV-damaged DNA-binding protein 2, UV-DDB 2
Primary ID Q92466
Links - -
Type protein
Relations 5
Function Required for DNA repair. Binds to DDB1 to form the UV-damaged DNA-binding protein complex (the UV-DDB complex). The UV-DDB complex may recognize UV-induced DNA damage and recruit proteins of the nucleotide excision repair pathway (the NER pathway) to initiate DNA repair. The UV-DDB complex preferentially binds to cyclobutane pyrimidine dimers (CPD), 6-4 photoproducts (6-4 PP), apurinic sites and short mismatches. Also appears to function as the substrate recognition module for the DCX (DDB1-CUL4-X-box) E3 ubiquitin-protein ligase complex DDB1-CUL4-ROC1 (also known as CUL4-DDB-ROC1 and CUL4-DDB-RBX1). The DDB1-CUL4-ROC1 complex may ubiquitinate histone H2A, histone H3 and histone H4 at sites of UV-induced DNA damage. The ubiquitination of histones may facilitate their removal from the nucleosome and promote subsequent DNA repair. The DDB1-CUL4-ROC1 complex also ubiquitinates XPC, which may enhance DNA-binding by XPC and promote NER. Isoform D1 and isoform D2 inhibit UV-damaged DNA repair.

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Relations

Regulator Mechanism target score
+ down-regulates img/indirect_inhibition.png unknown DDB2 0.33
Publications: 1 Organism: Homo Sapiens
+ form complex img/form-complex.png binding DDB2/DDB1
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png binding E2F1
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png deubiquitination DDB2 0.93
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png phosphorylation DDB2 0.18
Publications: 1 Organism: Homo Sapiens