Relation Results

Summary

Name PCSK7
Full Name Proprotein convertase subtilisin/kexin type 7
Synonyms Lymphoma proprotein convertase, Prohormone convertase 7, Proprotein convertase 7, PC7, Proprotein convertase 8, PC8, hPC8, Subtilisin/kexin-like protease PC7 | LPC, PC7, PC8, SPC7
Primary ID Q16549
Links - -
Type protein
Relations 12
Inhibitors SB-202190
Function Serine endoprotease that processes various proproteins by cleavage at paired basic amino acids, recognizing the RXXX[KR]R consensus motif. Likely func ...
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Type: Score: Layout: SPV 
0.20.20.20.20.20.20.20.20.80.20.80.2PCSK7CEBPAATF6ELK4PPP2CANFKBIACDC25BRELADDB2SB-202190KHSRP(-)-anisomycinETV6

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Relations
Regulator
Mechanism
target
score ℹ
+ PCSK7down-regulates img/direct_inhibition.png phosphorylation CEBPA 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-186202 Homo sapiens Neutrophil
pmid sentence
Addition of active p38a induced phosphorylation of wild-type c/ebp_? (c/ebp_?WT) on serine 21
Publications: 1 Organism: Homo Sapiens
+ PCSK7up-regulates img/direct-activation.png phosphorylation ATF6 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-89813 Homo sapiens
pmid sentence
We discovered that azc, an agent that causes the formation of abnormal proteins, stimulates the stress-activated kinase p38 mapk, which phosphorylates atf6
Publications: 1 Organism: Homo Sapiens
+ PCSK7up-regulates img/direct-activation.png phosphorylation ELK4 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-47771 Homo sapiens
pmid sentence
In contrast, the tcf sap-1a is efficiently phosphorylated by p38 map kinase in vitro and in vivo on the homologous residues ser381 and ser387
Publications: 1 Organism: Homo Sapiens
+ PCSK7up-regulates img/direct-activation.png phosphorylation PPP2CA 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-105783 Homo sapiens
pmid sentence
This together with the rapid kinetics of pp1-pp2a activation following p38 activation suggests that pp1 and/or pp2a complexes are direct targets for p38-mediated phosphorylation
Publications: 1 Organism: Homo Sapiens
+ PCSK7down-regulates img/indirect_inhibition.png NFKBIA 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-235837 Mus musculus C2C12 Cell, Myoblast
pmid sentence
The levels of ikb_? Where reduced in cells overexpressing mkk6 [] these results indicated that mkk6 was able to promote the degradation of the NF-kappaB inhibitor, in a p38-dependent manner.
Publications: 1 Organism: Mus Musculus
Tissue: Muscle, Skeletal Muscle
+ PCSK7down-regulates img/direct_inhibition.png phosphorylation CDC25B 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-107423 Homo sapiens
pmid sentence
We propose that regulation of cdc25b phosphorylation by p38 is a critical event for initiating the g2/m checkpoint after ultraviolet radiation
Publications: 1 Organism: Homo Sapiens
+ PCSK7up-regulates img/indirect-activation.png RELA 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-235734 Mus musculus C2C12 Cell, Myoblast
pmid sentence
Treatment with sb203580 significantly reduced this cooperation, consistent with the idea that p38 indirectly stimulates the transactivating activity of p65 through a mechanism involving cbp.
Publications: 1 Organism: Mus Musculus
Tissue: Muscle, Skeletal Muscle
+ PCSK7down-regulates img/indirect_inhibition.png DDB2 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-181278 Homo sapiens
pmid sentence
The data suggest that p38 mapk is involved in serine phosphorylation of ddb2, which may influence its ubiquitylation following irradiation.
Publications: 1 Organism: Homo Sapiens
+ SB-202190down-regulates img/direct_inhibition.png chemical inhibition PCSK7 0.8
Identifier Residue Sequence Organism Cell Line
SIGNOR-60130 Homo sapiens Monocyte
pmid sentence
Sb202190, a selective inhibitor of p38 mitogen activated protein kinase, is a powerful regulator of lps-induced mrnas in monocytes.
Publications: 1 Organism: Homo Sapiens
+ PCSK7down-regulates img/direct_inhibition.png phosphorylation KHSRP 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-143167 Homo sapiens Myoblast
pmid sentence
Ksrp phosphorylated by p38 displays compromised binding to are-containing transcripts and fails to promote their rapid decay,although it retains the ability to interact with the mrna degradation machinery.
Publications: 1 Organism: Homo Sapiens
Tissue: Muscle
+ (-)-anisomycinup-regulates img/direct-activation.png chemical activation PCSK7 0.8
Identifier Residue Sequence Organism Cell Line
SIGNOR-145496 Homo sapiens
pmid sentence
These results indicate that activation of p38 mapk by anisomycin induces ltd and subsequently occludes electrically induced ltd
Publications: 1 Organism: Homo Sapiens
Tissue: Brain
+ PCSK7down-regulates img/direct_inhibition.png phosphorylation ETV6 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-95622 Homo sapiens
pmid sentence
In vivo p38-dependent phosphorylation reduced trans-repressional abilities of tel through ets-binding consensus site
Publications: 1 Organism: Homo Sapiens
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