3.0
Summary
| Name |  WASF1View Modifications |
| Full Name | Wiskott-Aldrich syndrome protein family member 1 |
| Synonyms | WASP family protein member 1, Protein WAVE-1, Verprolin homology domain-containing protein 1 | KIAA0269, SCAR1, WAVE1 |
| Primary ID | Q92558 |
| Links |  -  -  |
| Type | protein |
| Relations | 4 |
| Function | Downstream effector molecule involved in the transmission of signals from tyrosine kinase receptors and small GTPases to the actin cytoskeleton. Promotes formation of actin filaments. Part of the WAVE complex that regulates lamellipodia formation (PubMed:29961568). The WAVE complex regulates actin filament reorganization via its interaction with the Arp2/3 complex (By similarity). As component of the WAVE1 complex, required for BDNF-NTRK2 endocytic trafficking and signaling from early endosomes (By similarity). Also involved in the regulation of mitochondrial dynamics (PubMed:29961568). |
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Modifications Tables
Relations
| Regulator | Mechanism | target | score ℹ | |
|---|---|---|---|---|
| + | SRC | up-regulates 
phosphorylation
|
WASF1 | 0.423 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | WASF1 | form complex 
binding
|
WRC complex | 0.891 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | BAIAP2 | up-regulates
binding
|
WASF1 | 0.61 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | SRGAP3 | up-regulates
binding
|
WASF1 | 0.576 |
| Publications: | 1 | Organism: | Homo Sapiens | |