| + |
WRC complex | up-regulates activity 
binding
|
ARP2/3 |
0.526 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-253573 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 20332100 |
The activated WAVE complex at the leading edge of lamellipodia promotes actin polymerization at the plasma membrane by activating the Arp2/3 complex |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
WRC complex | up-regulates 
|
F-actin_assembly |
0.7 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-253578 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 20332100 |
The activated WAVE complex at the leading edge of lamellipodia promotes actin polymerization at the plasma membrane by activating the Arp2/3 complex. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
NCKAP1 | form complex 
binding
|
WRC complex |
0.911 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-253569 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 21107423 |
WAVE proteins are constitutively associated with four additional proteins in cells: Sra1/Cyfip1, Nap1/Hem-2, Abi and HSPC300. The components of this ~400 kDa pentamer, termed the WAVE regulatory complex (WRC) have all been implicated in control of Arp2/3 complex-mediated actin assembly in a wide range of systems |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
CYFIP1 | form complex
binding
|
WRC complex |
0.901 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-253568 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 21107423 |
WAVE proteins are constitutively associated with four additional proteins in cells: Sra1/Cyfip1, Nap1/Hem-2, Abi and HSPC300. The components of this ~400 kDa pentamer, termed the WAVE regulatory complex (WRC) have all been implicated in control of Arp2/3 complex-mediated actin assembly in a wide range of systems |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
NHS | up-regulates activity
relocalization
|
WRC complex |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-253577 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 20332100 |
Excessive cell spreading and lamellipod extension as a result of NHS knockdown is likely to be a result of loss of WAVE complex regulation, leading to overactive WAVE activity or a dysregulation of nascent focal adhesions in lamellipodia.WAVE and NHS protein partners Abi1 and HSPC300, and the p34 subunit of the Arp2/3 complex, consistently localized at the edges of cells treated with NHS siRNA, independent of EGF stimulation and WAVE complex activation. These data show that localization of Abi1 and HSPC300 was altered in the absence of NHS. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
BRK1 | form complex
binding
|
WRC complex |
0.859 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-253570 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 21107423 |
WAVE proteins are constitutively associated with four additional proteins in cells: Sra1/Cyfip1, Nap1/Hem-2, Abi and HSPC300. The components of this ~400 kDa pentamer, termed the WAVE regulatory complex (WRC) have all been implicated in control of Arp2/3 complex-mediated actin assembly in a wide range of systems |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
ABI1 | form complex
binding
|
WRC complex |
0.841 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-253571 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 21107423 |
WAVE proteins are constitutively associated with four additional proteins in cells: Sra1/Cyfip1, Nap1/Hem-2, Abi and HSPC300. The components of this ~400 kDa pentamer, termed the WAVE regulatory complex (WRC) have all been implicated in control of Arp2/3 complex-mediated actin assembly in a wide range of systems |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
WASF1 | form complex
binding
|
WRC complex |
0.893 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-253572 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 21107423 |
WAVE proteins are constitutively associated with four additional proteins in cells: Sra1/Cyfip1, Nap1/Hem-2, Abi and HSPC300. The components of this ~400 kDa pentamer, termed the WAVE regulatory complex (WRC) have all been implicated in control of Arp2/3 complex-mediated actin assembly in a wide range of systems. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
3.0
WRC complex