Relation Results

Summary

Name WRC complex
Primary ID SIGNOR-C191
Type complex
Formed by WASF1, ABI1, NCKAP1, CYFIP1, BRK1
Relations 8

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Type: Score: Layout: SPV 
0.9130.8940.5330.8430.8610.70.9020.2NCKAP1WRC complexWASF1ARP2/3ABI1BRK1F-actin_assemblyCYFIP1NHS

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Relations
Regulator
Mechanism
target
score ℹ
+ NCKAP1form complex img/form-complex.png binding WRC complex 0.913
Identifier Residue Sequence Organism Cell Line
SIGNOR-253569 Homo sapiens
pmid sentence
WAVE proteins are constitutively associated with four additional proteins in cells: Sra1/Cyfip1, Nap1/Hem-2, Abi and HSPC300. The components of this ~400 kDa pentamer, termed the WAVE regulatory complex (WRC) have all been implicated in control of Arp2/3 complex-mediated actin assembly in a wide range of systems
Publications: 1 Organism: Homo Sapiens
+ WASF1form complex img/form-complex.png binding WRC complex 0.894
Identifier Residue Sequence Organism Cell Line
SIGNOR-253572 Homo sapiens
pmid sentence
WAVE proteins are constitutively associated with four additional proteins in cells: Sra1/Cyfip1, Nap1/Hem-2, Abi and HSPC300. The components of this ~400 kDa pentamer, termed the WAVE regulatory complex (WRC) have all been implicated in control of Arp2/3 complex-mediated actin assembly in a wide range of systems.
Publications: 1 Organism: Homo Sapiens
+ WRC complexup-regulates activity img/direct-activation.png binding ARP2/3 0.533
Identifier Residue Sequence Organism Cell Line
SIGNOR-253573 Homo sapiens
pmid sentence
The activated WAVE complex at the leading edge of lamellipodia promotes actin polymerization at the plasma membrane by activating the Arp2/3 complex
Publications: 1 Organism: Homo Sapiens
+ ABI1form complex img/form-complex.png binding WRC complex 0.843
Identifier Residue Sequence Organism Cell Line
SIGNOR-253571 Homo sapiens
pmid sentence
WAVE proteins are constitutively associated with four additional proteins in cells: Sra1/Cyfip1, Nap1/Hem-2, Abi and HSPC300. The components of this ~400 kDa pentamer, termed the WAVE regulatory complex (WRC) have all been implicated in control of Arp2/3 complex-mediated actin assembly in a wide range of systems
Publications: 1 Organism: Homo Sapiens
+ BRK1form complex img/form-complex.png binding WRC complex 0.861
Identifier Residue Sequence Organism Cell Line
SIGNOR-253570 Homo sapiens
pmid sentence
WAVE proteins are constitutively associated with four additional proteins in cells: Sra1/Cyfip1, Nap1/Hem-2, Abi and HSPC300. The components of this ~400 kDa pentamer, termed the WAVE regulatory complex (WRC) have all been implicated in control of Arp2/3 complex-mediated actin assembly in a wide range of systems
Publications: 1 Organism: Homo Sapiens
+ WRC complexup-regulates img/indirect-activation.png F-actin_assembly 0.7
Identifier Residue Sequence Organism Cell Line
SIGNOR-253578 Homo sapiens
pmid sentence
The activated WAVE complex at the leading edge of lamellipodia promotes actin polymerization at the plasma membrane by activating the Arp2/3 complex.
Publications: 1 Organism: Homo Sapiens
+ CYFIP1form complex img/form-complex.png binding WRC complex 0.902
Identifier Residue Sequence Organism Cell Line
SIGNOR-253568 Homo sapiens
pmid sentence
WAVE proteins are constitutively associated with four additional proteins in cells: Sra1/Cyfip1, Nap1/Hem-2, Abi and HSPC300. The components of this ~400 kDa pentamer, termed the WAVE regulatory complex (WRC) have all been implicated in control of Arp2/3 complex-mediated actin assembly in a wide range of systems
Publications: 1 Organism: Homo Sapiens
+ NHSup-regulates activity img/direct-activation.png relocalization WRC complex 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-253577 Homo sapiens
pmid sentence
Excessive cell spreading and lamellipod extension as a result of NHS knockdown is likely to be a result of loss of WAVE complex regulation, leading to overactive WAVE activity or a dysregulation of nascent focal adhesions in lamellipodia.WAVE and NHS protein partners Abi1 and HSPC300, and the p34 subunit of the Arp2/3 complex, consistently localized at the edges of cells treated with NHS siRNA, independent of EGF stimulation and WAVE complex activation. These data show that localization of Abi1 and HSPC300 was altered in the absence of NHS.
Publications: 1 Organism: Homo Sapiens
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