4.0
Summary
| Name |  HSPH1View Modifications |
| Full Name | Heat shock protein 105 kDa |
| Synonyms | Antigen NY-CO-25, Heat shock 110 kDa protein | HSP105, HSP110, KIAA0201 |
| Primary ID | Q92598 |
| Links |  -  -  |
| Type | protein |
| Relations | 4 |
| Function | Acts as a nucleotide-exchange factor (NEF) for chaperone proteins HSPA1A and HSPA1B, promoting the release of ADP from HSPA1A/B thereby triggering client/substrate protein release (PubMed:24318877). Prevents the aggregation of denatured proteins in cells under severe stress, on which the ATP levels decrease markedly. Inhibits HSPA8/HSC70 ATPase and chaperone activities (By similarity). |
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Modifications Tables
Relations
| Regulator | Mechanism | target | score ℹ | |
|---|---|---|---|---|
| + | CSNK2A2 | down-regulates activity 
phosphorylation
|
HSPH1 | 0.326 |
| Publications: | 1 | Organism: | In Vitro | |
| + | CSNK2A1 | down-regulates activity
phosphorylation
|
HSPH1 | 0.327 |
| Publications: | 1 | Organism: | In Vitro | |
| + | HSPH1 | up-regulates quantity by expression 
transcriptional regulation
|
HSPA1B | 0.479 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | HSPH1 | up-regulates quantity by expression
transcriptional regulation
|
HSPA1A | 0.503 |
| Publications: | 1 | Organism: | Homo Sapiens | |