Summary

Name HSPA1A
Full Name Heat shock 70 kDa protein 1A
Synonyms Heat shock 70 kDa protein 1, HSP70-1, HSP70.1 | HSPA1, HSX70
Primary ID P0DMV8
Links - -
Type protein
Relations 15
Function Molecular chaperone implicated in a wide variety of cellular processes, including protection of the proteome from stress, folding and transport of newly synthesized polypeptides, activation of proteolysis of misfolded proteins and the formation and dissociation of protein complexes. Plays a pivotal role in the protein quality control system, ensuring the correct folding of proteins, the re-folding of misfolded proteins and controlling the targeting of proteins for subsequent degradation. This is achieved through cycles of ATP binding, ATP hydrolysis and ADP release, mediated by co-chaperones. The co-chaperones have been shown to not only regulate different steps of the ATPase cycle, but they also have an individual specificity such that one co-chaperone may promote folding of a substrate while another may promote degradation. The affinity for polypeptides is regulated by its nucleotide bound state. In the ATP-bound form, it has a low affinity for substrate proteins. However, upon hydrolysis of the ATP to ADP, it undergoes a conformational change that increases its affinity for substrate proteins. It goes through repeated cycles of ATP hydrolysis and nucleotide exchange, which permits cycles of substrate binding and release. The co-chaperones are of three types

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Modifications Tables

Relations

Regulator Mechanism target score
+ up-regulates activity img/direct-activation.png phosphorylation HSPA1A 0.439
Publications: 1 Organism: In Vitro
+ down-regulates activity img/direct_inhibition.png binding HSPA1A 0.738
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png relocalization GSTA4 0.2
Publications: 1
+ down-regulates img/direct_inhibition.png binding NR3C1 0.615
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png binding APAF1 0.446
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/indirect_inhibition.png MAPK8 0.495
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png binding HSPA1A 0.2
Publications: 1 Organism: Chlorocebus Aethiops
+ up-regulates quantity img/direct-activation.png post transcriptional regulation ENPP1 0.2
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity by stabilization img/direct-activation.png binding PACRG 0.2
Publications: 1 Organism: In Vitro
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation HSPA1A 0.2
Publications: 1 Organism: Homo Sapiens
+ down-regulates quantity by destabilization img/direct_inhibition.png binding ACOT4 0.2
Publications: 1
+ up-regulates quantity by stabilization img/direct-activation.png binding NOD2 0.261
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation HSPA1A 0.325
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity by stabilization img/direct-activation.png binding FLCN 0.2
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation HSPA1A 0.474
Publications: 1 Organism: Homo Sapiens