| + |
PXDN | up-regulates quantity by stabilization 
catalytic activity
|
COL4A4 |
0.26 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-265250 |
|
|
Homo sapiens |
HeLa Cell |
| pmid |
sentence |
| 29305973 |
Peroxidasin (PXDN), an ECM protein with peroxidase activity, is integral to basement membrane consolidation through catalysis of sulfilimine bonds in collagen IV. PXDN has been shown to form dityrosine crosslinks and also catalyses sulfilimine bonds, in the presence of hypohalous acids, to connect collagen IV protomers, which are an integral component of the basement membrane |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
PXDN | up-regulates 
|
Epithelial-mesenchymal_transition |
0.7 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-265253 |
|
|
Homo sapiens |
HeLa Cell |
| pmid |
sentence |
| 29305973 |
Our findings show that Snai1 mediates repression of PXDN and consolidate a role for this ECM-modifier during EMT. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
SNAI1 | down-regulates quantity by repression 
transcriptional regulation
|
PXDN |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-265249 |
|
|
Homo sapiens |
HeLa Cell |
| pmid |
sentence |
| 29305973 |
TGF-β1 induced Snai1 binding to the PXDN promoter (as assessed by chromatin immunoprecipitation-PCR) and significantly repressed luciferase reporter gene expression, as did Snai1 overexpression. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
NFE2L2 | up-regulates quantity by expression
transcriptional regulation
|
PXDN |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-265248 |
|
|
Homo sapiens |
HeLa Cell, HEK-293 Cell |
| pmid |
sentence |
| 29953917 |
PXDN expression in response to H2O2 and the Nrf2-specific inducers, tert-butylhydroquinone (tBHQ) and sulforaphane (SFN), was determined by western blotting and immunofluorescence microscopy, in HeLa and HEK293 cells.We found that Nrf2 binds to and increases luciferase reporter gene expression from the PXDN promoter via a putative Nrf2-binding site. In summary, we show that PXDN is a novel target of the redox sensitive transcription factor Nrf2. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
3.0
PXDN
- 
- 