| + |
WNT7A | down-regulates 
|
Epithelial-mesenchymal_transition |
0.7 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-278875 |
|
|
Homo sapiens |
HEP-3B Cell |
| pmid |
sentence |
| 31886205 |
Wnt7a Protein Inhibits Migration of HCC Cells by Downregulating EMT |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
SNAI1 | up-regulates 
|
Epithelial-mesenchymal_transition |
0.7 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-252259 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 19055748 |
Taken together these results suggest that SNAI1 functional blockade is leading to partial re-expression of E-cadherin (i.e. at the level of transcription), to a decrease in PAI-1 and to a more collective migration, while the parental cells expressing SNAI1 have less E-cadherin, more PAI 1, and migrate individually. We suggest that the present study establishes a relation between SNAI1 function, PAI-1 distribution and EMT status. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-278097 |
|
|
Homo sapiens |
Hep-G2 Cell |
| pmid |
sentence |
| 27239445 |
Compelling evidence has demonstrated that SNAI1 plays a key role in the induction of EMT |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-265252 |
|
|
Homo sapiens |
HeLa Cell |
| pmid |
sentence |
| 29305973 |
Our findings show that Snai1 mediates repression of PXDN and consolidate a role for this ECM-modifier during EMT. |
|
| Publications: |
3 |
Organism: |
Homo Sapiens |
| + |
AXL | up-regulates activity 
binding
|
Epithelial-mesenchymal_transition |
0.7 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-277723 |
|
|
Homo sapiens |
Neutrophil |
| pmid |
sentence |
| 35022267 |
Gas6 and its main receptor AXL are overexpressed in pancreatic cancer and their expression correlates with poor prognosis.Gas6/AXL signalling in cancer cells is associated with tumour cell proliferation, epithelial mesenchymal transition and metastases. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
PLAU | up-regulates
|
Epithelial-mesenchymal_transition |
0.7 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-252264 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 19055748 |
Our data show that functional blockade of SNAI1 (SNAI1-dominant negative (DN)) leads to a partial re-expression of E-cadherin, and induces differential expression of EMT-related genes. This is confirmed by RT-PCR of PA system genes, where PAI-1 and uPA are decreased. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
HOOK1 | down-regulates
|
Epithelial-mesenchymal_transition |
0.7 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-260643 |
|
|
Homo sapiens |
A-549 Cell |
| pmid |
sentence |
| 25331952 |
The epithelial-mesenchymal transition (EMT) is an essential process for embryogenesis. It also plays a critical role in the initiation of tumor metastasis.Overexpression of Hook1 inhibited EMT while knockdown of Hook1 promoted EMT. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
KIFC1 | up-regulates
|
Epithelial-mesenchymal_transition |
0.7 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-266117 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 33361741 |
Kinesin Family Member C1 (KIFC1) Regulated by Centrosome Protein E (CENPE) Promotes Proliferation, Migration, and Epithelial-Mesenchymal Transition of Ovarian Cancer |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
SPRY4 | down-regulates
|
Epithelial-mesenchymal_transition |
0.7 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-253036 |
|
|
Homo sapiens |
Non-small Cell Lung Cancer Cell |
| pmid |
sentence |
| 20501643 |
Spry4 expression induces a reversal of the epithelial to mesenchymal transition characteristic of tumor cells. Treatment of a non-transformed lung epithelial cell line with shRNA to Spry4 led to decreased expression of epithelial markers and increased cell growth, supporting the concept of Spry4 acting as a tumor suppressor. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
STAT3 | up-regulates
|
Epithelial-mesenchymal_transition |
0.7 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-277690 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 26738736 |
Collectively, the activation of IL-6/STAT3 pathway contributed to the PSCs-induced EMT i |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Tissue: |
Fibroblast |
| + |
PROX1 | up-regulates
|
Epithelial-mesenchymal_transition |
0.7 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-254767 |
|
|
Homo sapiens |
Prostate Cancer Cell Line |
| pmid |
sentence |
| 27476001 |
Our present study reveals that DAB2IP prevents EMT and metastasis of prostate cancer through targeting PROX1 gene transcription and destabilizing HIF1α protein, which provides a new insight into mechanism that DAB2IP regulates EMT and PCa metastasis. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
CDH2 | up-regulates
|
Epithelial-mesenchymal_transition |
0.7 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-281219 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 31547193 |
N-cadherin is upregulated while E-cadherin is downregulated during EMT in cancers and this “cadherin switch” is associated with enhanced migratory and invasive traits, which caused inferior patient survival rate |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
OCLN | down-regulates
|
Epithelial-mesenchymal_transition |
0.7 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-281184 |
|
|
Mus musculus |
|
| pmid |
sentence |
| 12668723 |
When Snail was overexpressed in cultured mouse epithelial cells, EMT was induced with concomitant repression of the expression of claudins and occludin not only at the protein but also at the mRNA level. |
|
| Publications: |
1 |
Organism: |
Mus Musculus |
| + |
VIM | up-regulates
|
Epithelial-mesenchymal_transition |
0.7 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-281204 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 34638469 |
These signalling cascades are also implicated in the induction of EMT via the transcriptional control of EMT-associated transcription factors, such as SNAI1, TWIST, ZEB1, SLUG and TCF3 leading to vimentin expression, as described above (Figure 2). |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
CLDN3 | down-regulates
|
Epithelial-mesenchymal_transition |
0.7 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-281181 |
|
|
Mus musculus |
|
| pmid |
sentence |
| 12668723 |
When Snail was overexpressed in cultured mouse epithelial cells, EMT was induced with concomitant repression of the expression of claudins and occludin not only at the protein but also at the mRNA level. |
|
| Publications: |
1 |
Organism: |
Mus Musculus |
| + |
CLDN4 | down-regulates
|
Epithelial-mesenchymal_transition |
0.7 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-281182 |
|
|
Mus musculus |
|
| pmid |
sentence |
| 12668723 |
When Snail was overexpressed in cultured mouse epithelial cells, EMT was induced with concomitant repression of the expression of claudins and occludin not only at the protein but also at the mRNA level. |
|
| Publications: |
1 |
Organism: |
Mus Musculus |
| + |
CLDN7 | down-regulates
|
Epithelial-mesenchymal_transition |
0.7 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-281183 |
|
|
Mus musculus |
|
| pmid |
sentence |
| 12668723 |
When Snail was overexpressed in cultured mouse epithelial cells, EMT was induced with concomitant repression of the expression of claudins and occludin not only at the protein but also at the mRNA level. |
|
| Publications: |
1 |
Organism: |
Mus Musculus |
| + |
FN1 | up-regulates
|
Epithelial-mesenchymal_transition |
0.7 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-281221 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 28109697 |
Epithelial-Mesenchymal Transition (EMT) is a dynamic process through which epithelial cells transdifferentiate from an epithelial phenotype into a mesenchymal phenotype.Here we investigate the role of the extracellular matrix (ECM) protein fibronectin (FN) in this process. We demonstrate that inhibition of FN fibrillogenesis blocks activation of the Transforming Growth Factor-Beta (TGF-β) signaling pathway via Smad2 signaling, decreases cell migration and ultimately leads to inhibition of EMT. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-281222 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 28109697 |
Epithelial-Mesenchymal Transition (EMT) is a dynamic process through which epithelial cells transdifferentiate from an epithelial phenotype into a mesenchymal phenotype.Here we investigate the role of the extracellular matrix (ECM) protein fibronectin (FN) in this process. We demonstrate that inhibition of FN fibrillogenesis blocks activation of the Transforming Growth Factor-Beta (TGF-β) signaling pathway via Smad2 signaling, decreases cell migration and ultimately leads to inhibition of EMT. |
|
| Publications: |
2 |
Organism: |
Homo Sapiens |
| + |
MMP2 | up-regulates
|
Epithelial-mesenchymal_transition |
0.7 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-281242 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 31886121 |
Matrix metalloproteinases (MMPs) play significant roles in cellular regeneration, programmed death, angiogenesis, and many other essential tissular functions, involved in the normal development and also in pathological processes, such as the EMT. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
PKP2 | down-regulates
|
Epithelial-mesenchymal_transition |
0.7 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-281188 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 16314317 |
SIP1/ZEB2 is a member of the δEF-1 family of two-handed zinc finger nuclear factors. Here, we show that expression of SIP1 in human epithelial cells results in a clear morphological change from an epithelial to a mesenchymal phenotype. Induction of this epithelial dedifferentiation was accompanied by repression of several cell junctional proteins, with concomitant repression of their mRNA levels. The expression of these transcription factors is associated with epithelial mesenchymal transitions (EMT) during development. we could demonstrate physical interaction at the chromatin level between SIP1 and the promoter regions of E-cadherin, plakophilin 2, connexin 26 and ZO-3, all of which contain SIP1-binding sites. Hence, we have to conclude that E-cadherin and other junctional genes are simultaneously downregulated as part of the SIP1 driven reprogramming during EMT. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
GJB2 | down-regulates
|
Epithelial-mesenchymal_transition |
0.7 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-281189 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 16314317 |
SIP1/ZEB2 is a member of the δEF-1 family of two-handed zinc finger nuclear factors. Here, we show that expression of SIP1 in human epithelial cells results in a clear morphological change from an epithelial to a mesenchymal phenotype. Induction of this epithelial dedifferentiation was accompanied by repression of several cell junctional proteins, with concomitant repression of their mRNA levels. The expression of these transcription factors is associated with epithelial mesenchymal transitions (EMT) during development. we could demonstrate physical interaction at the chromatin level between SIP1 and the promoter regions of E-cadherin, plakophilin 2, connexin 26 and ZO-3, all of which contain SIP1-binding sites. Hence, we have to conclude that E-cadherin and other junctional genes are simultaneously downregulated as part of the SIP1 driven reprogramming during EMT. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
TJP3 | down-regulates
|
Epithelial-mesenchymal_transition |
0.7 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-281190 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 16314317 |
SIP1/ZEB2 is a member of the δEF-1 family of two-handed zinc finger nuclear factors. Here, we show that expression of SIP1 in human epithelial cells results in a clear morphological change from an epithelial to a mesenchymal phenotype. Induction of this epithelial dedifferentiation was accompanied by repression of several cell junctional proteins, with concomitant repression of their mRNA levels. The expression of these transcription factors is associated with epithelial mesenchymal transitions (EMT) during development. we could demonstrate physical interaction at the chromatin level between SIP1 and the promoter regions of E-cadherin, plakophilin 2, connexin 26 and ZO-3, all of which contain SIP1-binding sites. Hence, we have to conclude that E-cadherin and other junctional genes are simultaneously downregulated as part of the SIP1 driven reprogramming during EMT. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
CDH1 | down-regulates
|
Epithelial-mesenchymal_transition |
0.7 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-252261 |
|
|
|
|
| pmid |
sentence |
| 15601859 |
A hallmark characteristic of epithelial tumor progression as well as some processes of normal development is the loss of the epithelial phenotype and acquisition of a motile or mesenchymal phenotype. Such epithelial to mesenchymal transitions are accompanied by the loss of E-cadherin function by either transcriptional or posttranscriptional mechanisms. |
|
| Publications: |
1 |
| + |
HIF1A | up-regulates
|
Epithelial-mesenchymal_transition |
0.7 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-254768 |
|
|
Homo sapiens |
Prostate Cancer Cell Line |
| pmid |
sentence |
| 27476001 |
Our present study reveals that DAB2IP prevents EMT and metastasis of prostate cancer through targeting PROX1 gene transcription and destabilizing HIF1α protein, which provides a new insight into mechanism that DAB2IP regulates EMT and PCa metastasis. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
PXDN | up-regulates
|
Epithelial-mesenchymal_transition |
0.7 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-265253 |
|
|
Homo sapiens |
HeLa Cell |
| pmid |
sentence |
| 29305973 |
Our findings show that Snai1 mediates repression of PXDN and consolidate a role for this ECM-modifier during EMT. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
4.0
Epithelial-mesenchymal_transition