3.0
Summary
| Name |  STAM
|
| Full Name | Signal transducing adapter molecule 1 |
| Synonyms | STAM-1 | STAM1 |
| Primary ID | Q92783 |
| Links |  -  -  |
| Type | protein |
| Relations | 2 |
| Function | Involved in intracellular signal transduction mediated by cytokines and growth factors. Upon IL-2 and GM-CSL stimulation, it plays a role in signaling leading to DNA synthesis and MYC induction. May also play a role in T-cell development. Involved in down-regulation of receptor tyrosine kinase via multivesicular body (MVBs) when complexed with HGS (ESCRT-0 complex). The ESCRT-0 complex binds ubiquitin and acts as sorting machinery that recognizes ubiquitinated receptors and transfers them to further sequential lysosomal sorting/trafficking processes. |
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