+ |
RPGRIP1 | down-regulates activity
binding
|
RPGR |
0.738 |
Identifier |
Residue |
Sequence |
Organism |
Cell Line |
SIGNOR-253031 |
|
|
Homo sapiens |
|
pmid |
sentence |
20631154 |
The RPGR H98Q and F130C mutants exhibit compromised interaction with RPGRIP1, suggesting that RPGR–RPGRIP1 interaction may be an important determinant of RPGR activity. As RPGRIP1 appears to link RPGR to the cilium, it is possible that RPGR's effect on RAB8A function may occur in distinct subcellular compartments of photoreceptors and that RPGRIP1 and other interacting proteins may modulate targeting of RPGR to such compartments. |
|
Publications: |
1 |
Organism: |
Homo Sapiens |
+ |
RPGR | up-regulates activity
guanine nucleotide exchange factor
|
RAB8A |
0.44 |
Identifier |
Residue |
Sequence |
Organism |
Cell Line |
SIGNOR-253030 |
|
|
Homo sapiens |
|
pmid |
sentence |
20631154 |
PGR interacts with the small GTPase RAB8A, which participates in cilia biogenesis and maintenance. We show that RPGR primarily associates with the GDP-bound form of RAB8A and stimulates GDP/GTP nucleotide exchange. RPGR functions as a GEF for RAB8A and RPGR–RAB8A association may facilitate ciliary trafficking. |
|
Publications: |
1 |
Organism: |
Homo Sapiens |