3.0
Summary
| Name |  RAB8AView Modifications |
| Full Name | Ras-related protein Rab-8A |
| Synonyms | Oncogene c-mel | MEL, RAB8 |
| Primary ID | P61006 |
| Links |  -  -  |
| Type | protein |
| Relations | 8 |
| Function | The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different sets of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. That Rab is involved in polarized vesicular trafficking and neurotransmitter release. Together with RAB11A, RAB3IP, the exocyst complex, PARD3, PRKCI, ANXA2, CDC42 and DNMBP promotes transcytosis of PODXL to the apical membrane initiation sites (AMIS), apical surface formation and lumenogenesis (PubMed:20890297). Together with MYO5B and RAB11A participates in epithelial cell polarization (PubMed:21282656). May be involved in ciliogenesis (PubMed:21844891, PubMed:30398148). Together with MICALL2, may also regulate adherens junction assembly (By similarity). May play a role in insulin-induced transport to the plasma membrane of the glucose transporter GLUT4 and therefore play a role in glucose homeostasis (By similarity). Involved in autophagy (PubMed:27103069). |
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Modifications Tables
Relations
| Regulator | Mechanism | target | score ℹ | |
|---|---|---|---|---|
| + | PINK1 | down-regulates activity 
phosphorylation
|
RAB8A | 0.275 |
| Publications: | 1 | Organism: | In Vitro | |
| + | MAP3K7 | up-regulates activity 
phosphorylation
|
RAB8A | 0.254 |
| Publications: | 1 | Organism: | In Vitro | |
| + | STK24 | up-regulates activity
phosphorylation
|
RAB8A | 0.279 |
| Publications: | 1 | Organism: | In Vitro | |
| + | LRRK2 | up-regulates activity
phosphorylation
|
RAB8A | 0.337 |
| Publications: | 1 | Organism: | In Vitro | |
| + | CEP290 | up-regulates activity
binding
|
RAB8A | 0.732 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | BBsome complex | up-regulates activity
binding
|
RAB8A | 0.456 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | RPGR | up-regulates activity
guanine nucleotide exchange factor
|
RAB8A | 0.44 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | RAB8A | up-regulates 
|
Cilium_assembly | 0.7 |
| Publications: | 1 | Organism: | Homo Sapiens | |