3.0
Summary
| Name |  SMARCC1View Modifications |
| Full Name | SWI/SNF complex subunit SMARCC1 |
| Synonyms | BRG1-associated factor 155, BAF155, SWI/SNF complex 155 kDa subunit, SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily C member 1 | BAF155 |
| Primary ID | Q92922 |
| Links |  -  -  |
| Type | protein |
| Relations | 13 |
| Function | Involved in transcriptional activation and repression of select genes by chromatin remodeling (alteration of DNA-nucleosome topology). Component of SWI/SNF chromatin remodeling complexes that carry out key enzymatic activities, changing chromatin structure by altering DNA-histone contacts within a nucleosome in an ATP-dependent manner. May stimulate the ATPase activity of the catalytic subunit of the complex (PubMed:10078207, PubMed:29374058). Belongs to the neural progenitors-specific chromatin remodeling complex (npBAF complex) and the neuron-specific chromatin remodeling complex (nBAF complex). During neural development a switch from a stem/progenitor to a postmitotic chromatin remodeling mechanism occurs as neurons exit the cell cycle and become committed to their adult state. The transition from proliferating neural stem/progenitor cells to postmitotic neurons requires a switch in subunit composition of the npBAF and nBAF complexes. As neural progenitors exit mitosis and differentiate into neurons, npBAF complexes which contain ACTL6A/BAF53A and PHF10/BAF45A, are exchanged for homologous alternative ACTL6B/BAF53B and DPF1/BAF45B or DPF3/BAF45C subunits in neuron-specific complexes (nBAF). The npBAF complex is essential for the self-renewal/proliferative capacity of the multipotent neural stem cells. The nBAF complex along with CREST plays a role regulating the activity of genes essential for dendrite growth (By similarity). |
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Modifications Tables
Relations
| Regulator | Mechanism | target | score ℹ | |
|---|---|---|---|---|
| + | CARM1 | up-regulates activity 
methylation
|
SMARCC1 | 0.559 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | SMARCC1 | form complex 
binding
|
GBAF | 0.643 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | SMARCC1 | form complex
binding
|
SWI/SNF complex | 0.856 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | SMARCC1 | form complex
binding
|
Neural progenitor-specific SWI/SNF | 0.818 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | SMARCC1 | form complex
binding
|
Muscle cell-specific SWI/SNF ARID1B variant | 0.821 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| Tissue: | Muscle | |||
| + | SMARCC1 | form complex
binding
|
Embryonic stem cell-specific SWI/SNF | 0.739 |
| Publications: | 1 | Organism: | Mus Musculus | |
| + | SMARCA4 | up-regulates
binding
|
SMARCC1 | 0.948 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | SMARCC1 | form complex
binding
|
Muscle cell-specific SWI/SNF SMARCA4 variant | 0.812 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| Tissue: | Muscle | |||
| + | SMARCC1 | up-regulates quantity by stabilization 
|
SMARCE1 | 0.893 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | SMARCC1 | form complex
binding
|
Muscle cell-specific SWI/SNF ARID1A variant | 0.823 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| Tissue: | Muscle | |||
| + | SMARCA2 | up-regulates
binding
|
SMARCC1 | 0.907 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | SMARCC1 | form complex
binding
|
SWI/SNF ACTL6A-ARID1A-SMARCA2 variant | 0.827 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | SMARCC1 | form complex
binding
|
SWI/SNF ACTL6B varian | 0.79 |
| Publications: | 1 | Organism: | Homo Sapiens | |