4.0
Summary
| Name |  CARM1View Modifications |
| Full Name | Histone-arginine methyltransferase CARM1 |
| Synonyms | Coactivator-associated arginine methyltransferase 1, Protein arginine N-methyltransferase 4 | PRMT4 |
| Primary ID | Q86X55 |
| Links |  -  -  |
| Type | protein |
| Relations | 11 |
| Pathways | Satellite: Dystrophin glycoprotein complex regulation |
| Function | Methylates (mono- and asymmetric dimethylation) the guanidino nitrogens of arginyl residues in several proteins involved in DNA packaging, transcription regulation, pre-mRNA splicing, and mRNA stability. Recruited to promoters upon gene activation together with histone acetyltransferases from EP300/P300 and p160 families, methylates histone H3 at 'Arg-17' (H3R17me), forming mainly asymmetric dimethylarginine (H3R17me2a), leading to activate transcription via chromatin remodeling. During nuclear hormone receptor activation and TCF7L2/TCF4 activation, acts synergically with EP300/P300 and either one of the p160 histone acetyltransferases NCOA1/SRC1, NCOA2/GRIP1 and NCOA3/ACTR or CTNNB1/beta-catenin to activate transcription. During myogenic transcriptional activation, acts together with NCOA3/ACTR as a coactivator for MEF2C. During monocyte inflammatory stimulation, acts together with EP300/P300 as a coactivator for NF-kappa-B. Acts as coactivator for PPARG, promotes adipocyte differentiation and the accumulation of brown fat tissue. Plays a role in the regulation of pre-mRNA alternative splicing by methylation of splicing factors. Also seems to be involved in p53/TP53 transcriptional activation. Methylates EP300/P300, both at 'Arg-2142', which may loosen its interaction with NCOA2/GRIP1, and at 'Arg-580' and 'Arg-604' in the KIX domain, which impairs its interaction with CREB and inhibits CREB-dependent transcriptional activation. Also methylates arginine residues in RNA-binding proteins PABPC1, ELAVL1 and ELAV4, which may affect their mRNA-stabilizing properties and the half-life of their target mRNAs. |
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Modifications Tables
Relations
| Regulator | Mechanism | target | score ℹ | |
|---|---|---|---|---|
| + | CARM1 | up-regulates activity 
methylation
|
SMARCC1 | 0.537 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | CARM1 | down-regulates activity 
methylation
|
RUNX1 | 0.283 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | CARM1 | down-regulates activity
acetylation
|
MDH1 | 0.356 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | MAPK12 | down-regulates activity
phosphorylation
|
CARM1 | 0.364 |
| Publications: | 1 | Organism: | Mus Musculus | |
| + | KRAS | down-regulates activity 
|
CARM1 | 0.272 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | CARM1 | up-regulates
methylation
|
MEF2A | 0.387 |
| Publications: | 1 | Organism: | Mus Musculus | |
| Tissue: | Skeletal Muscle | |||
| + | CARM1 | up-regulates
methylation
|
PAX7 | 0.423 |
| Publications: | 2 | Organism: | Mus Musculus, Homo Sapiens | |
| Tissue: | Skeletal Muscle, Muscle, Skeletal Muscle | |||
| + | CARM1 | form complex 
binding
|
MAPK12/CARM1 | 0.364 |
| Publications: | 1 | |||
| Tissue: | Skeletal Muscle | |||
| + | CARM1 | down-regulates
|
Differentiation | 0.7 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | hsa-mir-223 | down-regulates quantity by repression
post transcriptional regulation
|
CARM1 | 0.4 |
| Publications: | 1 | Organism: | Homo Sapiens | |