| + |
USP13 | up-regulates activity 
deubiquitination
|
UBL4A |
0.633 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-272857 |
Lys48 |
QRLLFKGkALADGKR |
Homo sapiens |
HEK-293 Cell |
| pmid |
sentence |
| 24424410 |
USP13 and gp78 control ubiquitination of Ubl4A.These data suggest that USP13 and gp78 play antagonizing roles in regulation of Ubl4A ubiquitination: While gp78 assembles ubiquitin chains on Ubl4A, USP13 antagonizes this activity to limit Ubl4A ubiquitination.Ubiquitination of Ubl4A preferentially occurs on Lys48. We identify the Bag6 cofactor Ubl4A as a shared substrate of gp78 and USP13. USP13 depletion is associated with hyper-ubiquitination of Ubl4A and altered interaction between the Bag6 complex and its co-chaperone SGTA. Because the interaction of Ubl4A with SGTA is mediated by positively-charged residues in Ubl4A including Lys48 (Chartron et al., 2012; Xu et al., 2012), which happens to be the major ubiquitination site, the simplest model to explain reduced Bag6-SGTA interaction in USP13 knockdown cells is that ubiquitin conjugates on Ubl4A sterically hinder SGTA binding. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
CLK3 | up-regulates activity
phosphorylation
|
USP13 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-274122 |
Tyr708 |
EPLTMPGyGGAASAG |
Homo sapiens |
HuCCT-1 Cell |
| pmid |
sentence |
| 32453420 |
CLK3 directly phosphorylated USP13 at Y708, which promoted its binding to c-Myc, thereby preventing Fbxl14-mediated c-Myc ubiquitination and activating the transcription of purine metabolic genes. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
METTL3 | up-regulates quantity by stabilization
post transcriptional regulation
|
USP13 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-275839 |
|
|
|
|
| pmid |
sentence |
| 36528756 |
Furthermore, N6-methyladenosine methyltransferase-like 3 (METTL3) mediated stabilization of USP13 mRNA that required the m6A reader IGF2BP2. |
|
| Publications: |
1 |
| + |
USP13 | up-regulates quantity by stabilization
deubiquitination
|
ATG5 |
0.28 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-275838 |
|
|
|
|
| pmid |
sentence |
| 36528756 |
Here, we identified USP13 as an essential deubiquitinase that stabilizes ATG5 in a process that depends on the PAK1 serine/threonine-protein kinase and which enhances autophagy and promotes IM resistance in GIST cells. |
|
| Publications: |
1 |
| + |
USP13 | up-regulates quantity by stabilization
deubiquitination
|
MYC |
0.366 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-274124 |
|
|
Homo sapiens |
Glioma Stem Cell |
| pmid |
sentence |
| 27923907 |
In this study, we demonstrate that the deubiquitinase USP13 stabilizes c-Myc by antagonizing FBXL14-mediated ubiquitination to maintain GSC self-renewal and tumorigenic potential. USP13 was preferentially expressed in GSCs, and its depletion potently inhibited GSC proliferation and tumor growth by promoting c-Myc ubiquitination and degradation. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
BECN1 | up-regulates quantity by stabilization
deubiquitination
|
USP13 |
0.509 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-260296 |
|
|
Homo sapiens |
H4 Neuroglioma Cell |
| pmid |
sentence |
| 21962518 |
We found that endogenous Beclin1 can interact with USP13 and the interaction was reduced in the presence of spautin-1 (Figure 5C). Interestingly, the DUB activities were significantly increased when USP13 and USP10 coincubated together or with Beclin1 or all 3 proteins together, suggesting the DUB activity can be significantly enhanced when USP13 interacts with its substrate Beclin1 or USP10. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
USP13 | up-regulates quantity by stabilization
deubiquitination
|
BECN1 |
0.509 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-260295 |
|
|
Homo sapiens |
HEK-293T Cell |
| pmid |
sentence |
| 21962518 |
Similarly, the overexpression of USP13 reduced the levels of ubiquitinated Beclin1 which was inhibited by spautin-1 (Figure 4E) |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
3.0
USP13
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