3.0
Summary
| Name |  RBPMS
|
| Full Name | RNA-binding protein with multiple splicing |
| Synonyms | RBP-MS, Heart and RRM expressed sequence, Hermes | HERMES |
| Primary ID | Q93062 |
| Links |  -  -  |
| Type | protein |
| Relations | 1 |
| Function | Acts as a coactivator of transcriptional activity. Required to increase TGFB1/Smad-mediated transactivation. Acts through SMAD2, SMAD3 and SMAD4 to increase transcriptional activity. Increases phosphorylation of SMAD2 and SMAD3 on their C-terminal SSXS motif, possibly through recruitment of TGFBR1. Promotes the nuclear accumulation of SMAD2, SMAD3 and SMAD4 proteins (PubMed:26347403). Binds to poly(A) RNA (PubMed:17099224, PubMed:26347403). |
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Relations
| Regulator | Mechanism | target | score ℹ | |
|---|---|---|---|---|
| + | NUP98-HOXA9 | up-regulates quantity by expression 
transcriptional regulation
|
RBPMS | 0.2 |
| Publications: | 1 | Organism: | Homo Sapiens | |