| + |
NUP98-HOXA9 | down-regulates quantity by repression 
transcriptional regulation
|
CEBPA |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-261501 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 17442773 |
Over 102 cytoplasmic mRNAs were significantly altered in K562 myeloid leukemic cells transduced with NUP98‐HOXA9, 92 being increased and only 10 decreased. The transcription factor CCAAT enhancer binding protein‐α (C/EBPα), a tumor suppressor gene and a crucial regulator of granulopoiesis through inhibition of c‐JUN, was downmodulated by NUP98‐HOXA9 |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
NUP98-HOXA9 | up-regulates quantity by expression 
transcriptional regulation
|
RBPMS |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-261503 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 17442773 |
Over 102 cytoplasmic mRNAs were significantly altered in K562 myeloid leukemic cells transduced with NUP98‐HOXA9, 92 being increased and only 10 decreased. The gene for the RNA‐binding protein with multiple splicing (RBPMS) was upregulated in NUP98‐HOXA9–transduced cord blood CD34+ cells and also in the transcriptosomes of normal CD34+ and CD133+ cells. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
NUP98-HOXA9 | up-regulates quantity by expression
transcriptional regulation
|
PBX3 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-261504 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 17442773 |
Over 102 cytoplasmic mRNAs were significantly altered in K562 myeloid leukemic cells transduced with NUP98‐HOXA9, 92 being increased and only 10 decreased. PBX3, a member of the PBX family of TALE homeobox genes, is upregulated in both NUP98‐HOXA9–transduced adult and cord blood CD34+ cells (Table 3). |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
NUP98-HOXA9 | down-regulates quantity by repression
transcriptional regulation
|
PECAM1 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-261500 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 17442773 |
Over 102 cytoplasmic mRNAs were significantly altered in K562 myeloid leukemic cells transduced with NUP98‐HOXA9, 92 being increased and only 10 decreased. The platelet endothelial cell adhesion molecule PECAM1 is also downregulated by NUP98‐HOXA9. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
NUP98-HOXA9 | up-regulates quantity by expression
transcriptional regulation
|
CD44 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-261502 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 17442773 |
Over 102 cytoplasmic mRNAs were significantly altered in K562 myeloid leukemic cells transduced with NUP98‐HOXA9, 92 being increased and only 10 decreased. CD44 is also upregulated by NUP98‐HOXA9. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
NUP98-HOXA9 | up-regulates activity 
binding
|
HDAC1 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-261498 |
|
|
Homo sapiens |
HEK-293 Cell |
| pmid |
sentence |
| 28630438 |
NUP98-HOXA9 has an activator-repressor role in transcriptional regulation driven by p300 and HDAC1 interactions. The chromosomal translocation t(7;11)(p15, p15), encoding the fusion protein NUP98-HOXA9 (NHA9), is a rare poor risk cytogenetic event in AML associated with a particularly poor prognosis.In summary, NHA9 deregulates the expression of key leukemic genes, including MEIS1-HOXA9-PBX3 complex, through the enhancer binding and the direct interaction of the fusion protein with HDAC and p300 transcriptional regulators. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
NUP98-HOXA9 | up-regulates activity
binding
|
EP300 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-261497 |
|
|
Homo sapiens |
HEK-293 Cell |
| pmid |
sentence |
| 28630438 |
NUP98-HOXA9 has an activator-repressor role in transcriptional regulation driven by p300 and HDAC1 interactions. The chromosomal translocation t(7;11)(p15, p15), encoding the fusion protein NUP98-HOXA9 (NHA9), is a rare poor risk cytogenetic event in AML associated with a particularly poor prognosis.In summary, NHA9 deregulates the expression of key leukemic genes, including MEIS1-HOXA9-PBX3 complex, through the enhancer binding and the direct interaction of the fusion protein with HDAC and p300 transcriptional regulators. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
NUP98-HOXA9 | up-regulates quantity by expression
transcriptional regulation
|
RUNX1 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-261499 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 17442773 |
Over 102 cytoplasmic mRNAs were significantly altered in K562 myeloid leukemic cells transduced with NUP98‐HOXA9, 92 being increased and only 10 decreased. Runx1 is also upregulated in the NUP98‐HOXA9 transcriptosome and is a critical regulator of hematopoietic development and a frequent target for chromosomal translocation in leukemia |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
3.0
NUP98-HOXA9