Relation Results

Summary

Name PTP4A1
Full Name Protein tyrosine phosphatase type IVA 1
Synonyms PTP(CAAXI), Protein-tyrosine phosphatase 4a1, Protein-tyrosine phosphatase of regenerating liver 1, PRL-1 | PRL1, PTPCAAX1
Primary ID Q93096
Links - -
Type protein
Relations 3
Function Protein tyrosine phosphatase which stimulates progression from G1 into S phase during mitosis. May play a role in the development and maintenance of d ...
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Type: Score: Layout: SPV 
0.20.40.2WEE1PTP4A1hsa-miR-29c-5pCDK2

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Relations
Regulator
Mechanism
target
score ℹ
+ WEE1down-regulates activity img/direct_inhibition.png phosphorylation PTP4A1 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-278434 Homo sapiens
pmid sentence
In this study , we found that WEE1 phosphorylates PRL1 and promotes PRL1 degradation .|In this study, we demonstrated that WEE1 phosphorylates and inhibits PRL1 to regulate alternative splicing of CYCD1;1 and CYCD3;1 , which may represent a new cell cycle control mechanism.
Publications: 1 Organism: Homo Sapiens
+ hsa-miR-29c-5pdown-regulates quantity by repression img/direct_inhibition.png post transcriptional regulation PTP4A1 0.4
Identifier Residue Sequence Organism Cell Line
SIGNOR-278025 Homo sapiens SW-620 Cell
pmid sentence
These data provide evidence that PTP4A1 and GNA13 are direct targets of miR-29c, and that their expression is negatively regulated by miR-29c in CRC cells. | miR-29c directly targets PTP4A1 and GNA13 3'-UTR.
Publications: 1 Organism: Homo Sapiens
+ PTP4A1up-regulates img/indirect-activation.png CDK2 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-119418 Homo sapiens
pmid sentence
Cells overexpressing either prl-1 or prl-2 exhibited enhanced cyclin-dependent kinase 2 (cdk2) activity and significantly lower p21cip1/waf1 protein levels
Publications: 1 Organism: Homo Sapiens
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