Summary

Name NCLN
Full Name BOS complex subunit NCLN
Synonyms Nicalin, Nicastrin-like protein |
Primary ID Q969V3
Links - -
Type protein
Relations 3
Function Component of the multi-pass translocon (MPT) complex that mediates insertion of multi-pass membrane proteins into the lipid bilayer of membranes (PubMed:32820719, PubMed:36261522). The MPT complex takes over after the SEC61 complex: following membrane insertion of the first few transmembrane segments of proteins by the SEC61 complex, the MPT complex occludes the lateral gate of the SEC61 complex to promote insertion of subsequent transmembrane regions (PubMed:36261522). May antagonize Nodal signaling and subsequent organization of axial structures during mesodermal patterning, via its interaction with NOMO (By similarity).

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Relations

Regulator Mechanism target score ℹ
+ NCLNform complex img/form-complex.png binding BOS complex, NOMO1 variant 0.533
Publications: 1 Organism: Homo Sapiens
+ NCLNform complex img/form-complex.png binding BOS complex, NOMO2 variant 0.495
Publications: 1 Organism: Homo Sapiens
+ NCLNform complex img/form-complex.png binding BOS complex, NOMO3 variant 0.497
Publications: 1 Organism: Homo Sapiens