| + |
NOMO1 | form complex 
binding
|
BOS complex, NOMO1 variant |
0.468 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-280782 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 36261522 |
Here we define the composition, function and assembly of a translocon specialized for multipass membrane protein biogenesis3. This 'multipass translocon' is distinguished by three components that selectively bind the ribosome-Sec61 complex during multipass protein synthesis: the GET- and EMC-like (GEL), protein associated with translocon (PAT) and back of Sec61 (BOS) complexes. This ‘multipass translocon’ also contains CCDC47 and a three-protein complex comprising TMEM147, nicalin and NOMO13 (hereafter termed the BOS complex). |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
NCLN | form complex
binding
|
BOS complex, NOMO1 variant |
0.533 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-280783 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 36261522 |
Here we define the composition, function and assembly of a translocon specialized for multipass membrane protein biogenesis3. This 'multipass translocon' is distinguished by three components that selectively bind the ribosome-Sec61 complex during multipass protein synthesis: the GET- and EMC-like (GEL), protein associated with translocon (PAT) and back of Sec61 (BOS) complexes. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
TMEM147 | form complex
binding
|
BOS complex, NOMO1 variant |
0.433 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-280784 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 36261522 |
Here we define the composition, function and assembly of a translocon specialized for multipass membrane protein biogenesis3. This 'multipass translocon' is distinguished by three components that selectively bind the ribosome-Sec61 complex during multipass protein synthesis: the GET- and EMC-like (GEL), protein associated with translocon (PAT) and back of Sec61 (BOS) complexes. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
BOS complex, NOMO1 variant | up-regulates quantity by stabilization 
binding
|
SEC61 complex |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-280796 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 38896445 |
The protein translocon at the endoplasmic reticulum comprises the Sec61 translocation channel and numerous accessory factors that collectively facilitate the biogenesis of secretory and membrane proteins. The PAT, GEL, and BOS complexes are recruited to the ribosome-Sec61 complex at a later stage of multipass biogenesis to form the multipass translocon (MPT). The function of the BOS complex is unclear, but its contacts with Sec61 and the ribosome may facilitate multipass translocon (MPT) assembly or stability |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
4.0
BOS complex, NOMO1 variant
CPX-8021