Summary

Name TP53INP1
Full Name Tumor protein p53-inducible nuclear protein 1
Synonyms Stress-induced protein, p53-dependent damage-inducible nuclear protein 1, p53DINP1 | P53DINP1, SIP
Primary ID Q96A56
Links - -
Type protein
Relations 5
Function Antiproliferative and proapoptotic protein involved in cell stress response which acts as a dual regulator of transcription and autophagy. Acts as a positive regulator of autophagy. In response to cellular stress or activation of autophagy, relocates to autophagosomes where it interacts with autophagosome-associated proteins GABARAP, GABARAPL1/L2, MAP1LC3A/B/C and regulates autophagy. Acts as an antioxidant and plays a major role in p53/TP53-driven oxidative stress response. Possesses both a p53/TP53-independent intracellular reactive oxygen species (ROS) regulatory function and a p53/TP53-dependent transcription regulatory function. Positively regulates p53/TP53 and p73/TP73 and stimulates their capacity to induce apoptosis and regulate cell cycle. In response to double-strand DNA breaks, promotes p53/TP53 phosphorylation on 'Ser-46' and subsequent apoptosis. Acts as a tumor suppressor by inducing cell death by an autophagy and caspase-dependent mechanism. Can reduce cell migration by regulating the expression of SPARC.

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Relations

Regulator Mechanism target score ℹ
+ TP53INP1up-regulates img/direct-activation.png binding MAP1LC3A 0.353
Publications: 1 Organism: Homo Sapiens
+ TP53INP1up-regulates img/direct-activation.png binding MAP1LC3B 0.302
Publications: 1 Organism: Homo Sapiens
+ TP53INP1up-regulates img/direct-activation.png binding GABARAP 0.351
Publications: 1 Organism: Homo Sapiens
+ TP53INP1up-regulates img/direct-activation.png binding GABARAPL2 0.388
Publications: 1 Organism: Homo Sapiens
+ TP53INP1up-regulates img/direct-activation.png binding MAP1LC3C 0.282
Publications: 1 Organism: Homo Sapiens