Summary

Name GABARAPL2
Full Name Gamma-aminobutyric acid receptor-associated protein-like 2
Synonyms GABA(A) receptor-associated protein-like 2, Ganglioside expression factor 2, GEF-2, General protein transport factor p16, Golgi-associated ATPase enhancer of 16 kDa, GATE-16, MAP1 light chain 3-related protein | FLC3A, GEF2
Primary ID P60520
Links - -
Type protein
Relations 7
Pathways Autophagy
Function Ubiquitin-like modifier involved in intra-Golgi traffic (By similarity). Modulates intra-Golgi transport through coupling between NSF activity and SNAREs activation (By similarity). It first stimulates the ATPase activity of NSF which in turn stimulates the association with GOSR1 (By similarity). Involved in autophagy (PubMed:20418806, PubMed:23209295). Plays a role in mitophagy which contributes to regulate mitochondrial quantity and quality by eliminating the mitochondria to a basal level to fulfill cellular energy requirements and preventing excess ROS production (PubMed:20418806, PubMed:23209295). Whereas LC3s are involved in elongation of the phagophore membrane, the GABARAP/GATE-16 subfamily is essential for a later stage in autophagosome maturation (PubMed:20418806, PubMed:23209295).

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Relations

Regulator Mechanism target score
+ up-regulates activity img/direct-activation.png binding GABARAPL2 0.903
Publications: 1 Organism: In Vitro
Pathways:Autophagy
+ up-regulates activity img/direct-activation.png binding GABARAPL2 0.869
Publications: 1 Organism: In Vitro
Pathways:Autophagy
+ up-regulates img/direct-activation.png binding GABARAPL2 0.388
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png binding SQSTM1 0.862
Publications: 1 Organism: Homo Sapiens
Pathways:Autophagy
+ up-regulates img/direct-activation.png binding GABARAPL2 0.586
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png binding GABARAPL2 0.735
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png cleavage GABARAPL2 0.838
Publications: 1 Organism: In Vitro
Pathways:Autophagy