+ |
SRC | up-regulates activity
phosphorylation
|
FERMT2 |
0.384 |
Identifier |
Residue |
Sequence |
Organism |
Cell Line |
SIGNOR-266100 |
Tyr193 |
SKTMTPTyDAHDGSP |
Homo sapiens |
HEK-293 Cell |
pmid |
sentence |
26037143 |
Here we report that Src binds to and phosphorylates Kindlin-2 at Y193. Reciprocally, Kindlin-2-Y193 phosphorylation activates and maintains Src kinase activity. Kindlin-2-Y193 phosphorylation is also involved in its binding capacity with Migfilin and the recruitment of Migfilin to the focal adhesions. Functionally, we demonstrate that Kindlin-2-Y193 phosphorylation regulates Kindlin-2-mediated cell spreading and migration. |
|
Publications: |
1 |
Organism: |
Homo Sapiens |
+ |
FERMT2 | up-regulates activity
binding
|
FBLIM1 |
0.778 |
Identifier |
Residue |
Sequence |
Organism |
Cell Line |
SIGNOR-266108 |
|
|
Homo sapiens |
HEK-293 Cell |
pmid |
sentence |
26037143 |
Here we report that Src binds to and phosphorylates Kindlin-2 at Y193. Reciprocally, Kindlin-2-Y193 phosphorylation activates and maintains Src kinase activity. Kindlin-2-Y193 phosphorylation is also involved in its binding capacity with Migfilin and the recruitment of Migfilin to the focal adhesions. Functionally, we demonstrate that Kindlin-2-Y193 phosphorylation regulates Kindlin-2-mediated cell spreading and migration. |
|
Identifier |
Residue |
Sequence |
Organism |
Cell Line |
SIGNOR-266102 |
|
|
Mus musculus |
NIH-3T3 Cell |
pmid |
sentence |
24165133 |
Kindlin binds migfilin tandem LIM domains and regulates migfilin focal adhesion localization and recruitment dynamics. Two integrin-binding proteins present in FAs, kindlin-1 and kindlin-2, are important for integrin activation, FA formation, and signaling. By binding filamin, migfilin provides a link between kindlin and the actin cytoskeleton. |
|
Publications: |
2 |
Organism: |
Homo Sapiens, Mus Musculus |
+ |
FERMT2 | up-regulates activity
binding
|
SRC |
0.384 |
Identifier |
Residue |
Sequence |
Organism |
Cell Line |
SIGNOR-266101 |
|
|
Homo sapiens |
HEK-293 Cell |
pmid |
sentence |
26037143 |
Here we report that Src binds to and phosphorylates Kindlin-2 at Y193. Reciprocally, Kindlin-2-Y193 phosphorylation activates and maintains Src kinase activity. Kindlin-2-Y193 phosphorylation is also involved in its binding capacity with Migfilin and the recruitment of Migfilin to the focal adhesions. Functionally, we demonstrate that Kindlin-2-Y193 phosphorylation regulates Kindlin-2-mediated cell spreading and migration. |
|
Publications: |
1 |
Organism: |
Homo Sapiens |