Summary

Name ACD
Full Name Adrenocortical dysplasia protein homolog
Synonyms POT1 and TIN2-interacting protein | PIP1, PTOP, TINT1, TPP1
Primary ID Q96AP0
Links - -
Type protein
Relations 7
Function Component of the shelterin complex (telosome) that is involved in the regulation of telomere length and protection. Shelterin associates with arrays of double-stranded TTAGGG repeats added by telomerase and protects chromosome ends. Without its protective activity, telomeres are no longer hidden from the DNA damage surveillance and chromosome ends are inappropriately processed by DNA repair pathways. Promotes binding of POT1 to single-stranded telomeric DNA. Modulates the inhibitory effects of POT1 on telomere elongation. The ACD-POT1 heterodimer enhances telomere elongation by recruiting telomerase to telomeres and increasing its processivity. May play a role in organogenesis.

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Modifications Tables

Relations

Regulator Mechanism target score
+ up-regulates quantity by stabilization img/direct-activation.png polyubiquitination ACD 0.2
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png phosphorylation ACD 0.2
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png binding RPA2 0.2
Publications: 1
+ down-regulates activity img/direct_inhibition.png binding RPA1 0.2
Publications: 1
+ down-regulates activity img/direct_inhibition.png binding RPA3 0.2
Publications: 1
+ up-regulates img/direct-activation.png binding TERT 0.552
Publications: 1 Organism: Homo Sapiens
+ form complex img/form-complex.png binding POT1/ACD 0.878
Publications: 1 Organism: Homo Sapiens