4.0
Summary
| Name |  PBXIP1View Modifications |
| Full Name | Pre-B-cell leukemia transcription factor-interacting protein 1 |
| Synonyms | Hematopoietic PBX-interacting protein | HPIP |
| Primary ID | Q96AQ6 |
| Links |  -  -  |
| Type | protein |
| Relations | 6 |
| Function | Regulator of pre-B-cell leukemia transcription factors (BPXs) function. Inhibits the binding of PBX1-HOX complex to DNA and blocks the transcriptional activity of E2A-PBX1. Tethers estrogen receptor-alpha (ESR1) to microtubules and allows them to influence estrogen receptors-alpha signaling. {ECO:0000269|PubMed:10825160, ECO:0000269|PubMed:12360403, ECO:0000269|PubMed:17043237}. |
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Modifications Tables
Relations
| Regulator | Mechanism | target | score ℹ | |
|---|---|---|---|---|
| + | TBK1 | down-regulates quantity by destabilization 
phosphorylation
|
PBXIP1 | 0.289 |
| Publications: | 2 | Organism: | Homo Sapiens | |
| + | IKBKE | down-regulates quantity by destabilization
phosphorylation
|
PBXIP1 | 0.2 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | PBXIP1 | down-regulates activity
binding
|
PBX1 | 0.333 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | MDM2 | down-regulates quantity by destabilization
polyubiquitination
|
PBXIP1 | 0.289 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | PBXIP1 | down-regulates activity
binding
|
PBX2 | 0.268 |
| Publications: | 1 | Organism: | Homo Sapiens | |