| + |
IKBKE | down-regulates activity 
phosphorylation
|
TANK |
0.734 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-262713 |
Ser100 |
QPQDKVIsGIAREKL |
Chlorocebus aethiops |
COS-7 Cell |
| pmid |
sentence |
| 10759890 |
IKK-i phosphorylates I-TRAF. In vitro kinase assays demonstrate that IKK‐i phosphorylates I‐TRAF in the middle portion that associates with TRAF2. Interestingly, TRAF2 is freed from the I‐TRAF/TRAF2 complex after I‐TRAF phosphorylation. TRAF2 isdistributed throughout the cytoplasm, in the formof inactive an I-TRAF/TRAF2 complex |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-262715 |
Ser126 |
RKETSARsLGSPLLH |
Chlorocebus aethiops |
COS-7 Cell |
| pmid |
sentence |
| 10759890 |
IKK-i phosphorylates I-TRAF. In vitro kinase assays demonstrate that IKK‐i phosphorylates I‐TRAF in the middle portion that associates with TRAF2. Interestingly, TRAF2 is freed from the I‐TRAF/TRAF2 complex after I‐TRAF phosphorylation. TRAF2 isdistributed throughout the cytoplasm, in the formof inactive an I-TRAF/TRAF2 complex |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-262716 |
Ser178 |
TATETQCsVPIQCTD |
Chlorocebus aethiops |
COS-7 Cell |
| pmid |
sentence |
| 10759890 |
IKK-i phosphorylates I-TRAF. In vitro kinase assays demonstrate that IKK‐i phosphorylates I‐TRAF in the middle portion that associates with TRAF2. Interestingly, TRAF2 is freed from the I‐TRAF/TRAF2 complex after I‐TRAF phosphorylation. TRAF2 isdistributed throughout the cytoplasm, in the formof inactive an I-TRAF/TRAF2 complex |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-262717 |
Ser208 |
DINRGAPsITSVTPR |
Chlorocebus aethiops |
COS-7 Cell |
| pmid |
sentence |
| 10759890 |
IKK-i phosphorylates I-TRAF. In vitro kinase assays demonstrate that IKK‐i phosphorylates I‐TRAF in the middle portion that associates with TRAF2. Interestingly, TRAF2 is freed from the I‐TRAF/TRAF2 complex after I‐TRAF phosphorylation. TRAF2 isdistributed throughout the cytoplasm, in the formof inactive an I-TRAF/TRAF2 complex |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-262718 |
Ser228 |
EEDTSFEsLSKFNVK |
Chlorocebus aethiops |
COS-7 Cell |
| pmid |
sentence |
| 10759890 |
IKK-i phosphorylates I-TRAF. In vitro kinase assays demonstrate that IKK‐i phosphorylates I‐TRAF in the middle portion that associates with TRAF2. Interestingly, TRAF2 is freed from the I‐TRAF/TRAF2 complex after I‐TRAF phosphorylation. TRAF2 isdistributed throughout the cytoplasm, in the formof inactive an I-TRAF/TRAF2 complex |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-262719 |
Ser257 |
PERPGILsPATSEAV |
Chlorocebus aethiops |
COS-7 Cell |
| pmid |
sentence |
| 10759890 |
IKK-i phosphorylates I-TRAF. In vitro kinase assays demonstrate that IKK‐i phosphorylates I‐TRAF in the middle portion that associates with TRAF2. Interestingly, TRAF2 is freed from the I‐TRAF/TRAF2 complex after I‐TRAF phosphorylation. TRAF2 isdistributed throughout the cytoplasm, in the formof inactive an I-TRAF/TRAF2 complex |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-262720 |
Ser406 |
CQAVFPPsITSRGDF |
Chlorocebus aethiops |
COS-7 Cell |
| pmid |
sentence |
| 10759890 |
IKK-i phosphorylates I-TRAF. In vitro kinase assays demonstrate that IKK‐i phosphorylates I‐TRAF in the middle portion that associates with TRAF2. Interestingly, TRAF2 is freed from the I‐TRAF/TRAF2 complex after I‐TRAF phosphorylation. TRAF2 isdistributed throughout the cytoplasm, in the formof inactive an I-TRAF/TRAF2 complex |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-262721 |
Ser409 |
VFPPSITsRGDFLRH |
Chlorocebus aethiops |
COS-7 Cell |
| pmid |
sentence |
| 10759890 |
IKK-i phosphorylates I-TRAF. In vitro kinase assays demonstrate that IKK‐i phosphorylates I‐TRAF in the middle portion that associates with TRAF2. Interestingly, TRAF2 is freed from the I‐TRAF/TRAF2 complex after I‐TRAF phosphorylation. TRAF2 isdistributed throughout the cytoplasm, in the formof inactive an I-TRAF/TRAF2 complex |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-262722 |
Ser49 |
REQQEQLsLQQTIID |
Chlorocebus aethiops |
COS-7 Cell |
| pmid |
sentence |
| 10759890 |
IKK-i phosphorylates I-TRAF. In vitro kinase assays demonstrate that IKK‐i phosphorylates I‐TRAF in the middle portion that associates with TRAF2. Interestingly, TRAF2 is freed from the I‐TRAF/TRAF2 complex after I‐TRAF phosphorylation. TRAF2 isdistributed throughout the cytoplasm, in the formof inactive an I-TRAF/TRAF2 complex |
|
| Publications: |
9 |
Organism: |
Chlorocebus Aethiops |
| + |
IKBKE | down-regulates quantity by destabilization
phosphorylation
|
PBXIP1 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-276618 |
Ser147 |
REEGRCSsSDDDTDV |
Homo sapiens |
HEK-293 Cell |
| pmid |
sentence |
| 24488098 |
Accordingly, we identified the microtubule-associated HPIP, a positive regulator of oncogenic AKT signaling, as a novel MDM2 substrate. MDM2-dependent HPIP degradation occurs in breast cancer cells on its phosphorylation by the estrogen-activated kinase TBK1. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
IKBKE | up-regulates activity 
phosphorylation
|
NFATC1 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-276778 |
Ser151 |
VLPSSKRsPSTATLS |
Homo sapiens |
PC-3 Cell |
| pmid |
sentence |
| 31730483 |
Phosphorylation of NFATC1 at PIM1 target sites is essential for its ability to promote prostate cancer cell migration and invasion. Here we have identified ten PIM1 target sites in NFATC1 and found that prevention of their phosphorylation significantly decreases the transcriptional activity as well as the pro-migratory and pro-invasive effects of NFATC1 in prostate cancer cells. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
IKBKE | up-regulates
phosphorylation
|
ESR1 |
0.346 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-161834 |
Ser167 |
GGRERLAsTNDKGSM |
Homo sapiens |
Breast Cancer Cell |
| pmid |
sentence |
| 19940156 |
Here, we show that ikkepsilon interacts with and phosphorylates estrogen receptor alpha (eralpha) on serine 167 in vitro and in vivo. As a result, ikkepsilon induces eralpha transactivation activity and enhances eralpha binding to dna. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
PPM1A | down-regulates activity
dephosphorylation
|
IKBKE |
0.283 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-277072 |
Ser172 |
DDDEKFVsVYGTEEY |
Homo sapiens |
|
| pmid |
sentence |
| 27419230 |
PPM1A directly dephosphorylates both MAVS and TBK1 and IKKepsilon.|In a similar in vitro phosphatase assay, incubation of PPM1A also eliminated TBK1 and IKKepsilon phosphorylation at Ser 172 residue, evidenced by phospho-S172 immunoblotting (XREF_FIG, F and G).|These observations suggest that PPM1A may block kinase activities of TBK1 and IKKepsilon. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
IKBKE | down-regulates activity
phosphorylation
|
IRF1 |
0.357 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-276480 |
Ser215 |
DLYNFQVsPMPSTSE |
Homo sapiens |
HEK-293 Cell |
| pmid |
sentence |
| 24396068 |
We demonstrated that IKK-ε phosphorylated the transcription factor IFN regulatory factor 1 (IRF-1) at amino acid (aa) 215/219/221 in primary CD4(+) T cells and blocked its transcriptional activity. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-276478 |
Ser219 |
FQVSPMPsTSEATTD |
Homo sapiens |
HEK-293 Cell |
| pmid |
sentence |
| 24396068 |
We demonstrated that IKK-ε phosphorylated the transcription factor IFN regulatory factor 1 (IRF-1) at amino acid (aa) 215/219/221 in primary CD4(+) T cells and blocked its transcriptional activity. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-276479 |
Ser221 |
VSPMPSTsEATTDED |
Homo sapiens |
HEK-293 Cell |
| pmid |
sentence |
| 24396068 |
We demonstrated that IKK-ε phosphorylated the transcription factor IFN regulatory factor 1 (IRF-1) at amino acid (aa) 215/219/221 in primary CD4(+) T cells and blocked its transcriptional activity. |
|
| Publications: |
3 |
Organism: |
Homo Sapiens |
| + |
IKBKE | up-regulates activity
phosphorylation
|
TRAF3IP2 |
0.425 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-262883 |
Ser328 |
KVILNYPsPWDHEER |
Homo sapiens |
|
| pmid |
sentence |
| 21822257 |
IKKi was required for IL-17-induced phosphorylation of Act1 on Ser311, adjacent to a putative TRAF-binding motif. Substitution of the serine at position 311 with alanine impaired the IL-17-mediated Act1-TRAF2-TRAF5 interaction and gene expression. Thus, IKKi is a kinase newly identified as modulating IL-17 signaling through its effect on Act1 phosphorylation and consequent function. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
IKBKE | down-regulates quantity by destabilization
phosphorylation
|
NFKBIA |
0.498 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-249367 |
Ser36 |
RHDSGLDsMKDEEYE |
|
|
| pmid |
sentence |
| 11815618 |
Nuclear factor-kappaB activation depends on phosphorylation and degradation of its inhibitor protein, IkapapB. |TBK-1 and IKK-i phosphorylate Ser36 of IkappaBalpha. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-167524 |
|
|
Homo sapiens |
Macrophage |
| pmid |
sentence |
| 20717897 |
The activated ikk complex then phosphorylates ikbalfa (an inhibitor of nf-kb) thereby targeting it for ubiquitination and proteasomal degradation. |
|
| Publications: |
2 |
Organism: |
, Homo Sapiens |
| Pathways: | COVID-19 Causal Network, Toll like receptors |
| + |
IKBKE | up-regulates activity
phosphorylation
|
IRF3 |
0.732 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-178363 |
Ser385 |
MARVGGAsSLENTVD |
in vitro |
|
| pmid |
sentence |
| 18440553 |
Virus-induced phosphoactivation of irf-3, thought to be mediated directly or indirectly by ikkepsilon And/or tbk1 occurs in the c-terminal region of irf-3 at seven ser/thr residues, 385sslentvdlhisnshplslts405 (fig. 1a).Within This region, irf-3 has two phosphorylation sites: site 1 includes ser385 and ser386, whereas site 2 includes ser396, ser398, ser402, ser405, and thr404. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-178367 |
Ser386 |
ARVGGASsLENTVDL |
in vitro |
|
| pmid |
sentence |
| 18440553 |
Virus-induced phosphoactivation of irf-3, thought to be mediated directly or indirectly by ikk? And/or tbk1 occurs in the c-terminal region of irf-3 at seven ser/thr residues, 385sslentvdlhisnshplslts405 (fig. 1a).Within This region, irf-3 has two phosphorylation sites: site 1 includes ser385 and ser386, whereas site 2 includes ser396, ser398, ser402, ser405, and thr404. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-178371 |
Ser396 |
NTVDLHIsNSHPLSL |
in vitro |
|
| pmid |
sentence |
| 18440553 |
Virus-induced phosphoactivation of irf-3, thought to be mediated directly or indirectly by ikk? And/or tbk1 occurs in the c-terminal region of irf-3 at seven ser/thr residues, 385sslentvdlhisnshplslts405 (fig. 1a).Within This region, irf-3 has two phosphorylation sites: site 1 includes ser385 and ser386, whereas site 2 includes ser396, ser398, ser402, ser405, and thr404. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-178375 |
Ser398 |
VDLHISNsHPLSLTS |
in vitro |
|
| pmid |
sentence |
| 18440553 |
Virus-induced phosphoactivation of irf-3, thought to be mediated directly or indirectly by ikk? And/or tbk1 occurs in the c-terminal region of irf-3 at seven ser/thr residues, 385sslentvdlhisnshplslts405 (fig. 1a).Within This region, irf-3 has two phosphorylation sites: site 1 includes ser385 and ser386, whereas site 2 includes ser396, ser398, ser402, ser405, and thr404. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-178379 |
Ser402 |
ISNSHPLsLTSDQYK |
in vitro |
|
| pmid |
sentence |
| 18440553 |
Virus-induced phosphoactivation of irf-3, thought to be mediated directly or indirectly by ikk? And/or tbk1 occurs in the c-terminal region of irf-3 at seven ser/thr residues, 385sslentvdlhisnshplslts405 (fig. 1a).Within This region, irf-3 has two phosphorylation sites: site 1 includes ser385 and ser386, whereas site 2 includes ser396, ser398, ser402, ser405, and thr404. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-178383 |
Ser405 |
SHPLSLTsDQYKAYL |
in vitro |
|
| pmid |
sentence |
| 18440553 |
Virus-induced phosphoactivation of irf-3, thought to be mediated directly or indirectly by ikk? And/or tbk1 occurs in the c-terminal region of irf-3 at seven ser/thr residues, 385sslentvdlhisnshplslts405 (fig. 1a).Within This region, irf-3 has two phosphorylation sites: site 1 includes ser385 and ser386, whereas site 2 includes ser396, ser398, ser402, ser405, and thr404. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-178387 |
Thr404 |
NSHPLSLtSDQYKAY |
in vitro |
|
| pmid |
sentence |
| 18440553 |
Virus-induced phosphoactivation of irf-3, thought to be mediated directly or indirectly by ikk? And/or tbk1 occurs in the c-terminal region of irf-3 at seven ser/thr residues, 385sslentvdlhisnshplslts405 (fig. 1a).Within This region, irf-3 has two phosphorylation sites: site 1 includes ser385 and ser386, whereas site 2 includes ser396, ser398, ser402, ser405, and thr404. |
|
| Publications: |
7 |
Organism: |
In Vitro |
| Pathways: | COVID-19 Causal Network, Innate Immune Response, SARS-CoV INNATE RESPONSE TO dsRNA, Toll like receptors |
| + |
IKBKE | down-regulates quantity by destabilization
phosphorylation
|
YAP1 |
0.451 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-277355 |
Ser419 |
TPDDFLNsVDEMDTG |
Homo sapiens |
|
| pmid |
sentence |
| 28481329 |
Virus-activated kinase IKKɛ phosphorylated YAP at Ser403 and thereby triggered degradation of YAP in lysosomes and, consequently, relief of YAP-mediated inhibition of the cellular antiviral response. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
IKBKE |
phosphorylation
|
CDK2AP1 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-264780 |
Ser46 |
LSDYGPPsLGYTQGT |
in vitro |
|
| pmid |
sentence |
| 22427660 |
CDK2AP1 is phosphorylated at a conserved Ser-46 site in the N-terminal "intrinsically disordered" region by IkappaB kinase epsilon. |
|
| Publications: |
1 |
Organism: |
In Vitro |
| + |
IKBKE | up-regulates
phosphorylation
|
RELA |
0.45 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-129939 |
Ser468 |
AVFTDLAsVDNSEFQ |
Homo sapiens |
|
| pmid |
sentence |
| 15489227 |
Overexpressed ikkepsilon and tbk1 phosphorylate ser-536 in vivo and in vitro. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-129943 |
Ser536 |
SGDEDFSsIADMDFS |
Homo sapiens |
|
| pmid |
sentence |
| 15489227 |
Overexpressed ikkepsilon and tbk1 phosphorylate ser-536 in vivo and in vitro. |
|
| Publications: |
2 |
Organism: |
Homo Sapiens |
| + |
IKBKE | up-regulates
phosphorylation
|
IRF7 |
0.675 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-79139 |
Ser471 |
GTQREGVsSLDSSSL |
Homo sapiens |
|
| pmid |
sentence |
| 10893229 |
In response to a viral infection, phosphorylated on ser-477 and ser-479 by tbk1 and ikbke1. Phosphorylation, and subsequent activation is inhibited by vaccinia virus protein e3. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-79143 |
Ser472 |
TQREGVSsLDSSSLS |
Homo sapiens |
|
| pmid |
sentence |
| 10893229 |
In response to a viral infection, phosphorylated on ser-477 and ser-479 by tbk1 and ikbke1. Phosphorylation, and subsequent activation is inhibited by vaccinia virus protein e3. |
|
| Publications: |
2 |
Organism: |
Homo Sapiens |
| Pathways: | Innate Immune Response |
| + |
IKBKE | down-regulates quantity by destabilization
phosphorylation
|
FAF1 |
0.287 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-277618 |
Ser556 |
EREAIRLsLEQALPP |
Homo sapiens |
HEK-293T Cell |
| pmid |
sentence |
| 30472208 |
Upon virus infection, the kinase IKKɛ directly phosphorylates FAF1 at Ser556 and triggers FAF1 de-aggregation. Moreover, Ser556 phosphorylation promotes FAF1 lysosomal degradation, consequently relieving FAF1-dependent suppression of MAVS. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
IKBKE | down-regulates
phosphorylation
|
FOXO |
0.418 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-252949 |
Ser644 |
GLDFNFDsLISTQNV |
Homo sapiens |
Breast Cancer Cell, Lung Cancer Cell |
| pmid |
sentence |
| 23691078 |
Ikbke phosphorylation and inhibition of foxo3a: a mechanism of ikbke oncogenic functionhere we report that ikbke regulates foxo3a through phosphorylation of foxo3a-ser644. The phosphorylation of foxo3a resulted in its degradation and nuclear-cytoplasmic translocation. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
IKBKE | down-regulates
phosphorylation
|
FOXO3 |
0.418 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-202054 |
Ser644 |
GLDFNFDsLISTQNV |
Homo sapiens |
|
| pmid |
sentence |
| 23691078 |
Ikbke phosphorylation and inhibition of foxo3a: a mechanism of ikbke oncogenic functionhere we report that ikbke regulates foxo3a through phosphorylation of foxo3a-ser644. The phosphorylation of foxo3a resulted in its degradation and nuclear-cytoplasmic translocation. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
IKBKE | up-regulates
phosphorylation
|
STAT1 |
0.411 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-154775 |
Ser727 |
TDNLLPMsPEEFDEV |
Homo sapiens |
|
| pmid |
sentence |
| 17502367 |
All stats are phosphorylated on at least one serine residue in their tad specifically, ser727 in stats 1 and 3 and ser721 in stat4. Stat serine kinases have been identified through the use of inhibitors, dominant-negative alleles, and in vitro kinase assays. They include mapk (p38mapk: stats 1, 3, 4;erk: stat3, 5;jnk: stat3), pkc_ (stat1, stat3), mtor (stat3), nlk (stat3 (42)), and camkii and ikk_ (stat1 (39, 40, 43)).STAT Serine phosphorylation regulates transcriptional activity (see below). |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
IKBKE | up-regulates activity
phosphorylation
|
IKBKE |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-276637 |
Thr501 |
ELRSRLRtLAEVLSR |
Homo sapiens |
A-549 Cell |
| pmid |
sentence |
| 24882218 |
As previously reported, IKKε underwent rapid activation by auto-phosphorylation on T501 upon IFNβ treatment of control A549 cells, which was impaired by TRIM6si (Figure 4D) |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | COVID-19 Causal Network, Innate Immune Response, SARS-CoV INNATE RESPONSE TO dsRNA, Toll like receptors |
| + |
EGFR | up-regulates activity
phosphorylation
|
IKBKE |
0.26 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-277242 |
Tyr153 |
GEEGQSIyKLTDFGA |
Homo sapiens |
|
| pmid |
sentence |
| 27287717 |
EGFRL858R/T790M phosphorylates IKBKE at tyrosine residues. While wild-type and mutant EGFR directly interacted with IKBKE, only mutant EGFR phosphorylated IKBKE on residues Y153 and Y179. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-277243 |
Tyr179 |
SVYGTEEyLHPDMYE |
Homo sapiens |
|
| pmid |
sentence |
| 27287717 |
EGFRL858R/T790M phosphorylates IKBKE at tyrosine residues. While wild-type and mutant EGFR directly interacted with IKBKE, only mutant EGFR phosphorylated IKBKE on residues Y153 and Y179. |
|
| Publications: |
2 |
Organism: |
Homo Sapiens |
| Pathways: | COVID-19 Causal Network |
| + |
IKBKE | up-regulates
phosphorylation
|
REL/RELA |
0.406 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-217664 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 16888014 |
The present results demonstrate that ikkepsilon- and tbk1-mediated phosphorylation of crel in the c-terminal td leads to cytoplasmic dissociation of a crel-ikb_ complex and nuclear accumulation of crel. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
MAVS | up-regulates activity
binding
|
IKBKE |
0.826 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-260144 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 25636800 |
After ligand binding, cGAS and RIG-I signal through respective adaptor proteins STING and MAVS to recruit the kinases IKK and TBK1, which then activate the transcription factors NF-κB and interferon regulatory factor 3 (IRF3), respectively. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | COVID-19 Causal Network, Innate Immune Response, SARS-CoV INNATE RESPONSE TO dsRNA |
| + |
IKBKE | up-regulates
phosphorylation
|
REL |
0.362 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-148620 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 16888014 |
The present results demonstrate that ikkepsilon- and tbk1-mediated phosphorylation of crel in the c-terminal td leads to cytoplasmic dissociation of a crel-ikb_ complex and nuclear accumulation of crel. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
IKBKE | up-regulates activity
phosphorylation
|
NfKb-p65/p50 |
0.433 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-217379 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 15489227 |
Constitutive and interleukin-1-inducible Phosphorylation of p65 NF-{kappa}B at Serine 536 Is Mediated by Multiple Protein Kinases Including I{kappa}B Kinase (IKK)-{alpha}, IKK{beta}, IKK{epsilon}, TRAF Family Member-Associated (TANK)-binding Kinase 1 (TBK1). Overexpressed ikkepsilon and tbk1 phosphorylate ser-536 in vivo and in vitro. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | COVID-19 Causal Network, Innate Immune Response, SARS-CoV INNATE RESPONSE TO dsRNA, Toll like receptors |
| + |
TBK1 | up-regulates activity
binding
|
IKBKE |
0.628 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-178053 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 18353649 |
Whereas nemo assembles some but not all ikk complexes [12,13], recent reports provide strong experimental evidence for a role of tank [also called traf-interacting protein (i-traf)], nak-associated protein (nap1) and similar to nap1 tbk1 adaptor (sintbad) in the assembly of tbk1 and ikk-e kinase complexes that phosphorylate irf3 and irf7 and promote type i ifn gene induction |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | COVID-19 Causal Network, Innate Immune Response, SARS-CoV INNATE RESPONSE TO dsRNA, Toll like receptors |
| + |
ORF4b | down-regulates activity
binding
|
IKBKE |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-260592 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 26631542 |
Previous studies have shown that MERS-CoV ORF4b antagonizes the early antiviral alpha/beta interferon (IFN-α/β) response, which may significantly contribute to MERS-CoV pathogenesis; however, the underlying mechanism is poorly understood. Here, we found that ORF4b in the cytoplasm could specifically bind to TANK binding kinase 1 (TBK1) and IκB kinase epsilon (IKKε), suppress the molecular interaction between mitochondrial antiviral signaling protein (MAVS) and IKKε, and inhibit IFN regulatory factor 3 (IRF3) phosphorylation and subsequent IFN-β production. these results indicate that MERS-CoV ORF4b inhibits the induction of type I IFN through a direct interaction with IKKε/TBK1 in the cytoplasm |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | COVID-19 Causal Network, SARS-CoV INNATE RESPONSE TO dsRNA |
| + |
N-[3-[[5-iodo-4-[3-[[oxo(thiophen-2-yl)methyl]amino]propylamino]-2-pyrimidinyl]amino]phenyl]-1-pyrrolidinecarboxamide | down-regulates
chemical inhibition
|
IKBKE |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-190792 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| Other |
|
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
IKBKE | up-regulates activity
binding
|
TBK1 |
0.628 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-260155 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 24622840 |
STING recruits TBK1 and IKKε and forms the TBK1-IKKε complex via the association with TRAF3. The TBK1 complex induces the phosphorylation, dimerization, and nuclear translocation of IRF3. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | COVID-19 Causal Network, Innate Immune Response, SARS-CoV INNATE RESPONSE TO dsRNA, Toll like receptors |
| + |
MOV10 | up-regulates activity
binding
|
IKBKE |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-261138 |
|
|
Homo sapiens |
HEK-293 Cell |
| pmid |
sentence |
| 27016603 |
MOV10 enhances IRF3 activation and IRF3-mediated gene induction. This indicated that MOV10-mediated antiviral activity is most likely mediated through IKKε and not through TBK1. Involvement of IKKε was further established by examining the physical interaction of MOV10 and IKKε. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
3.0
IKBKE
- 
- 