+ |
IKBKE | down-regulates activity
phosphorylation
|
TANK |
0.733 |
Identifier |
Residue |
Sequence |
Organism |
Cell Line |
SIGNOR-262713 |
Ser100 |
QPQDKVIsGIAREKL |
Chlorocebus aethiops |
COS-7 Cell |
pmid |
sentence |
10759890 |
IKK-i phosphorylates I-TRAF. In vitro kinase assays demonstrate that IKK‐i phosphorylates I‐TRAF in the middle portion that associates with TRAF2. Interestingly, TRAF2 is freed from the I‐TRAF/TRAF2 complex after I‐TRAF phosphorylation. TRAF2 isdistributed throughout the cytoplasm, in the formof inactive an I-TRAF/TRAF2 complex |
|
Identifier |
Residue |
Sequence |
Organism |
Cell Line |
SIGNOR-262715 |
Ser126 |
RKETSARsLGSPLLH |
Chlorocebus aethiops |
COS-7 Cell |
pmid |
sentence |
10759890 |
IKK-i phosphorylates I-TRAF. In vitro kinase assays demonstrate that IKK‐i phosphorylates I‐TRAF in the middle portion that associates with TRAF2. Interestingly, TRAF2 is freed from the I‐TRAF/TRAF2 complex after I‐TRAF phosphorylation. TRAF2 isdistributed throughout the cytoplasm, in the formof inactive an I-TRAF/TRAF2 complex |
|
Identifier |
Residue |
Sequence |
Organism |
Cell Line |
SIGNOR-262716 |
Ser178 |
TATETQCsVPIQCTD |
Chlorocebus aethiops |
COS-7 Cell |
pmid |
sentence |
10759890 |
IKK-i phosphorylates I-TRAF. In vitro kinase assays demonstrate that IKK‐i phosphorylates I‐TRAF in the middle portion that associates with TRAF2. Interestingly, TRAF2 is freed from the I‐TRAF/TRAF2 complex after I‐TRAF phosphorylation. TRAF2 isdistributed throughout the cytoplasm, in the formof inactive an I-TRAF/TRAF2 complex |
|
Identifier |
Residue |
Sequence |
Organism |
Cell Line |
SIGNOR-262717 |
Ser208 |
DINRGAPsITSVTPR |
Chlorocebus aethiops |
COS-7 Cell |
pmid |
sentence |
10759890 |
IKK-i phosphorylates I-TRAF. In vitro kinase assays demonstrate that IKK‐i phosphorylates I‐TRAF in the middle portion that associates with TRAF2. Interestingly, TRAF2 is freed from the I‐TRAF/TRAF2 complex after I‐TRAF phosphorylation. TRAF2 isdistributed throughout the cytoplasm, in the formof inactive an I-TRAF/TRAF2 complex |
|
Identifier |
Residue |
Sequence |
Organism |
Cell Line |
SIGNOR-262718 |
Ser228 |
EEDTSFEsLSKFNVK |
Chlorocebus aethiops |
COS-7 Cell |
pmid |
sentence |
10759890 |
IKK-i phosphorylates I-TRAF. In vitro kinase assays demonstrate that IKK‐i phosphorylates I‐TRAF in the middle portion that associates with TRAF2. Interestingly, TRAF2 is freed from the I‐TRAF/TRAF2 complex after I‐TRAF phosphorylation. TRAF2 isdistributed throughout the cytoplasm, in the formof inactive an I-TRAF/TRAF2 complex |
|
Identifier |
Residue |
Sequence |
Organism |
Cell Line |
SIGNOR-262719 |
Ser257 |
PERPGILsPATSEAV |
Chlorocebus aethiops |
COS-7 Cell |
pmid |
sentence |
10759890 |
IKK-i phosphorylates I-TRAF. In vitro kinase assays demonstrate that IKK‐i phosphorylates I‐TRAF in the middle portion that associates with TRAF2. Interestingly, TRAF2 is freed from the I‐TRAF/TRAF2 complex after I‐TRAF phosphorylation. TRAF2 isdistributed throughout the cytoplasm, in the formof inactive an I-TRAF/TRAF2 complex |
|
Identifier |
Residue |
Sequence |
Organism |
Cell Line |
SIGNOR-262720 |
Ser406 |
CQAVFPPsITSRGDF |
Chlorocebus aethiops |
COS-7 Cell |
pmid |
sentence |
10759890 |
IKK-i phosphorylates I-TRAF. In vitro kinase assays demonstrate that IKK‐i phosphorylates I‐TRAF in the middle portion that associates with TRAF2. Interestingly, TRAF2 is freed from the I‐TRAF/TRAF2 complex after I‐TRAF phosphorylation. TRAF2 isdistributed throughout the cytoplasm, in the formof inactive an I-TRAF/TRAF2 complex |
|
Identifier |
Residue |
Sequence |
Organism |
Cell Line |
SIGNOR-262721 |
Ser409 |
VFPPSITsRGDFLRH |
Chlorocebus aethiops |
COS-7 Cell |
pmid |
sentence |
10759890 |
IKK-i phosphorylates I-TRAF. In vitro kinase assays demonstrate that IKK‐i phosphorylates I‐TRAF in the middle portion that associates with TRAF2. Interestingly, TRAF2 is freed from the I‐TRAF/TRAF2 complex after I‐TRAF phosphorylation. TRAF2 isdistributed throughout the cytoplasm, in the formof inactive an I-TRAF/TRAF2 complex |
|
Identifier |
Residue |
Sequence |
Organism |
Cell Line |
SIGNOR-262722 |
Ser49 |
REQQEQLsLQQTIID |
Chlorocebus aethiops |
COS-7 Cell |
pmid |
sentence |
10759890 |
IKK-i phosphorylates I-TRAF. In vitro kinase assays demonstrate that IKK‐i phosphorylates I‐TRAF in the middle portion that associates with TRAF2. Interestingly, TRAF2 is freed from the I‐TRAF/TRAF2 complex after I‐TRAF phosphorylation. TRAF2 isdistributed throughout the cytoplasm, in the formof inactive an I-TRAF/TRAF2 complex |
|
Publications: |
9 |
Organism: |
Chlorocebus Aethiops |
+ |
IKBKE | up-regulates
phosphorylation
|
ESR1 |
0.346 |
Identifier |
Residue |
Sequence |
Organism |
Cell Line |
SIGNOR-161834 |
Ser167 |
GGRERLAsTNDKGSM |
Homo sapiens |
Breast Cancer Cell |
pmid |
sentence |
19940156 |
Here, we show that ikkepsilon interacts with and phosphorylates estrogen receptor alpha (eralpha) on serine 167 in vitro and in vivo. As a result, ikkepsilon induces eralpha transactivation activity and enhances eralpha binding to dna. |
|
Publications: |
1 |
Organism: |
Homo Sapiens |
+ |
IKBKE | up-regulates activity
phosphorylation
|
TRAF3IP2 |
0.426 |
Identifier |
Residue |
Sequence |
Organism |
Cell Line |
SIGNOR-262883 |
Ser328 |
KVILNYPsPWDHEER |
Homo sapiens |
|
pmid |
sentence |
21822257 |
IKKi was required for IL-17-induced phosphorylation of Act1 on Ser311, adjacent to a putative TRAF-binding motif. Substitution of the serine at position 311 with alanine impaired the IL-17-mediated Act1-TRAF2-TRAF5 interaction and gene expression. Thus, IKKi is a kinase newly identified as modulating IL-17 signaling through its effect on Act1 phosphorylation and consequent function. |
|
Publications: |
1 |
Organism: |
Homo Sapiens |
+ |
IKBKE | down-regulates quantity by destabilization
phosphorylation
|
NFKBIA |
0.501 |
Identifier |
Residue |
Sequence |
Organism |
Cell Line |
SIGNOR-249367 |
Ser36 |
RHDSGLDsMKDEEYE |
|
|
pmid |
sentence |
11815618 |
Nuclear factor-kappaB activation depends on phosphorylation and degradation of its inhibitor protein, IkapapB. |TBK-1 and IKK-i phosphorylate Ser36 of IkappaBalpha. |
|
Identifier |
Residue |
Sequence |
Organism |
Cell Line |
SIGNOR-167524 |
|
|
Homo sapiens |
Macrophage |
pmid |
sentence |
20717897 |
The activated ikk complex then phosphorylates ikbalfa (an inhibitor of nf-kb) thereby targeting it for ubiquitination and proteasomal degradation. |
|
Publications: |
2 |
Organism: |
, Homo Sapiens |
Pathways: | COVID-19 Causal Network, Toll like receptors |
+ |
IKBKE | up-regulates activity
phosphorylation
|
IRF3 |
0.732 |
Identifier |
Residue |
Sequence |
Organism |
Cell Line |
SIGNOR-178363 |
Ser385 |
MARVGGAsSLENTVD |
in vitro |
|
pmid |
sentence |
18440553 |
Virus-induced phosphoactivation of irf-3, thought to be mediated directly or indirectly by ikkepsilon And/or tbk1 occurs in the c-terminal region of irf-3 at seven ser/thr residues, 385sslentvdlhisnshplslts405 (fig. 1a).Within This region, irf-3 has two phosphorylation sites: site 1 includes ser385 and ser386, whereas site 2 includes ser396, ser398, ser402, ser405, and thr404. |
|
Identifier |
Residue |
Sequence |
Organism |
Cell Line |
SIGNOR-178367 |
Ser386 |
ARVGGASsLENTVDL |
in vitro |
|
pmid |
sentence |
18440553 |
Virus-induced phosphoactivation of irf-3, thought to be mediated directly or indirectly by ikk? And/or tbk1 occurs in the c-terminal region of irf-3 at seven ser/thr residues, 385sslentvdlhisnshplslts405 (fig. 1a).Within This region, irf-3 has two phosphorylation sites: site 1 includes ser385 and ser386, whereas site 2 includes ser396, ser398, ser402, ser405, and thr404. |
|
Identifier |
Residue |
Sequence |
Organism |
Cell Line |
SIGNOR-178371 |
Ser396 |
NTVDLHIsNSHPLSL |
in vitro |
|
pmid |
sentence |
18440553 |
Virus-induced phosphoactivation of irf-3, thought to be mediated directly or indirectly by ikk? And/or tbk1 occurs in the c-terminal region of irf-3 at seven ser/thr residues, 385sslentvdlhisnshplslts405 (fig. 1a).Within This region, irf-3 has two phosphorylation sites: site 1 includes ser385 and ser386, whereas site 2 includes ser396, ser398, ser402, ser405, and thr404. |
|
Identifier |
Residue |
Sequence |
Organism |
Cell Line |
SIGNOR-178375 |
Ser398 |
VDLHISNsHPLSLTS |
in vitro |
|
pmid |
sentence |
18440553 |
Virus-induced phosphoactivation of irf-3, thought to be mediated directly or indirectly by ikk? And/or tbk1 occurs in the c-terminal region of irf-3 at seven ser/thr residues, 385sslentvdlhisnshplslts405 (fig. 1a).Within This region, irf-3 has two phosphorylation sites: site 1 includes ser385 and ser386, whereas site 2 includes ser396, ser398, ser402, ser405, and thr404. |
|
Identifier |
Residue |
Sequence |
Organism |
Cell Line |
SIGNOR-178379 |
Ser402 |
ISNSHPLsLTSDQYK |
in vitro |
|
pmid |
sentence |
18440553 |
Virus-induced phosphoactivation of irf-3, thought to be mediated directly or indirectly by ikk? And/or tbk1 occurs in the c-terminal region of irf-3 at seven ser/thr residues, 385sslentvdlhisnshplslts405 (fig. 1a).Within This region, irf-3 has two phosphorylation sites: site 1 includes ser385 and ser386, whereas site 2 includes ser396, ser398, ser402, ser405, and thr404. |
|
Identifier |
Residue |
Sequence |
Organism |
Cell Line |
SIGNOR-178383 |
Ser405 |
SHPLSLTsDQYKAYL |
in vitro |
|
pmid |
sentence |
18440553 |
Virus-induced phosphoactivation of irf-3, thought to be mediated directly or indirectly by ikk? And/or tbk1 occurs in the c-terminal region of irf-3 at seven ser/thr residues, 385sslentvdlhisnshplslts405 (fig. 1a).Within This region, irf-3 has two phosphorylation sites: site 1 includes ser385 and ser386, whereas site 2 includes ser396, ser398, ser402, ser405, and thr404. |
|
Identifier |
Residue |
Sequence |
Organism |
Cell Line |
SIGNOR-178387 |
Thr404 |
NSHPLSLtSDQYKAY |
in vitro |
|
pmid |
sentence |
18440553 |
Virus-induced phosphoactivation of irf-3, thought to be mediated directly or indirectly by ikk? And/or tbk1 occurs in the c-terminal region of irf-3 at seven ser/thr residues, 385sslentvdlhisnshplslts405 (fig. 1a).Within This region, irf-3 has two phosphorylation sites: site 1 includes ser385 and ser386, whereas site 2 includes ser396, ser398, ser402, ser405, and thr404. |
|
Publications: |
7 |
Organism: |
In Vitro |
Pathways: | COVID-19 Causal Network, Innate Immune Response, SARS-CoV INNATE RESPONSE TO dsRNA, Toll like receptors |
+ |
IKBKE |
phosphorylation
|
CDK2AP1 |
0.2 |
Identifier |
Residue |
Sequence |
Organism |
Cell Line |
SIGNOR-264780 |
Ser46 |
LSDYGPPsLGYTQGT |
in vitro |
|
pmid |
sentence |
22427660 |
CDK2AP1 is phosphorylated at a conserved Ser-46 site in the N-terminal "intrinsically disordered" region by IkappaB kinase epsilon. |
|
Publications: |
1 |
Organism: |
In Vitro |
+ |
IKBKE | up-regulates
phosphorylation
|
RELA |
0.453 |
Identifier |
Residue |
Sequence |
Organism |
Cell Line |
SIGNOR-129939 |
Ser468 |
AVFTDLAsVDNSEFQ |
Homo sapiens |
|
pmid |
sentence |
15489227 |
Overexpressed ikkepsilon and tbk1 phosphorylate ser-536 in vivo and in vitro. |
|
Identifier |
Residue |
Sequence |
Organism |
Cell Line |
SIGNOR-129943 |
Ser536 |
SGDEDFSsIADMDFS |
Homo sapiens |
|
pmid |
sentence |
15489227 |
Overexpressed ikkepsilon and tbk1 phosphorylate ser-536 in vivo and in vitro. |
|
Publications: |
2 |
Organism: |
Homo Sapiens |
+ |
IKBKE | up-regulates
phosphorylation
|
IRF7 |
0.674 |
Identifier |
Residue |
Sequence |
Organism |
Cell Line |
SIGNOR-79139 |
Ser471 |
GTQREGVsSLDSSSL |
Homo sapiens |
|
pmid |
sentence |
10893229 |
In response to a viral infection, phosphorylated on ser-477 and ser-479 by tbk1 and ikbke1. Phosphorylation, and subsequent activation is inhibited by vaccinia virus protein e3. |
|
Identifier |
Residue |
Sequence |
Organism |
Cell Line |
SIGNOR-79143 |
Ser472 |
TQREGVSsLDSSSLS |
Homo sapiens |
|
pmid |
sentence |
10893229 |
In response to a viral infection, phosphorylated on ser-477 and ser-479 by tbk1 and ikbke1. Phosphorylation, and subsequent activation is inhibited by vaccinia virus protein e3. |
|
Publications: |
2 |
Organism: |
Homo Sapiens |
Pathways: | Innate Immune Response |
+ |
IKBKE | down-regulates
phosphorylation
|
FOXO |
0.422 |
Identifier |
Residue |
Sequence |
Organism |
Cell Line |
SIGNOR-252949 |
Ser644 |
GLDFNFDsLISTQNV |
Homo sapiens |
Breast Cancer Cell, Lung Cancer Cell |
pmid |
sentence |
23691078 |
Ikbke phosphorylation and inhibition of foxo3a: a mechanism of ikbke oncogenic functionhere we report that ikbke regulates foxo3a through phosphorylation of foxo3a-ser644. The phosphorylation of foxo3a resulted in its degradation and nuclear-cytoplasmic translocation. |
|
Publications: |
1 |
Organism: |
Homo Sapiens |
+ |
IKBKE | down-regulates
phosphorylation
|
FOXO3 |
0.422 |
Identifier |
Residue |
Sequence |
Organism |
Cell Line |
SIGNOR-202054 |
Ser644 |
GLDFNFDsLISTQNV |
Homo sapiens |
|
pmid |
sentence |
23691078 |
Ikbke phosphorylation and inhibition of foxo3a: a mechanism of ikbke oncogenic functionhere we report that ikbke regulates foxo3a through phosphorylation of foxo3a-ser644. The phosphorylation of foxo3a resulted in its degradation and nuclear-cytoplasmic translocation. |
|
Publications: |
1 |
Organism: |
Homo Sapiens |
+ |
IKBKE | up-regulates
phosphorylation
|
STAT1 |
0.414 |
Identifier |
Residue |
Sequence |
Organism |
Cell Line |
SIGNOR-154775 |
Ser727 |
TDNLLPMsPEEFDEV |
Homo sapiens |
|
pmid |
sentence |
17502367 |
All stats are phosphorylated on at least one serine residue in their tad specifically, ser727 in stats 1 and 3 and ser721 in stat4. Stat serine kinases have been identified through the use of inhibitors, dominant-negative alleles, and in vitro kinase assays. They include mapk (p38mapk: stats 1, 3, 4;erk: stat3, 5;jnk: stat3), pkc_ (stat1, stat3), mtor (stat3), nlk (stat3 (42)), and camkii and ikk_ (stat1 (39, 40, 43)).STAT Serine phosphorylation regulates transcriptional activity (see below). |
|
Publications: |
1 |
Organism: |
Homo Sapiens |
+ |
MOV10 | up-regulates activity
binding
|
IKBKE |
0.2 |
Identifier |
Residue |
Sequence |
Organism |
Cell Line |
SIGNOR-261138 |
|
|
Homo sapiens |
HEK-293 Cell |
pmid |
sentence |
27016603 |
MOV10 enhances IRF3 activation and IRF3-mediated gene induction. This indicated that MOV10-mediated antiviral activity is most likely mediated through IKKε and not through TBK1. Involvement of IKKε was further established by examining the physical interaction of MOV10 and IKKε. |
|
Publications: |
1 |
Organism: |
Homo Sapiens |
+ |
N-[3-[[5-iodo-4-[3-[[oxo(thiophen-2-yl)methyl]amino]propylamino]-2-pyrimidinyl]amino]phenyl]-1-pyrrolidinecarboxamide | down-regulates
chemical inhibition
|
IKBKE |
0.8 |
Identifier |
Residue |
Sequence |
Organism |
Cell Line |
SIGNOR-190792 |
|
|
Homo sapiens |
|
pmid |
sentence |
Other |
|
|
Publications: |
1 |
Organism: |
Homo Sapiens |
+ |
IKBKE | up-regulates activity
phosphorylation
|
NfKb-p65/p50 |
0.436 |
Identifier |
Residue |
Sequence |
Organism |
Cell Line |
SIGNOR-217379 |
|
|
Homo sapiens |
|
pmid |
sentence |
15489227 |
Constitutive and interleukin-1-inducible Phosphorylation of p65 NF-{kappa}B at Serine 536 Is Mediated by Multiple Protein Kinases Including I{kappa}B Kinase (IKK)-{alpha}, IKK{beta}, IKK{epsilon}, TRAF Family Member-Associated (TANK)-binding Kinase 1 (TBK1). Overexpressed ikkepsilon and tbk1 phosphorylate ser-536 in vivo and in vitro. |
|
Publications: |
1 |
Organism: |
Homo Sapiens |
Pathways: | COVID-19 Causal Network, Innate Immune Response, SARS-CoV INNATE RESPONSE TO dsRNA, Toll like receptors |
+ |
ORF4b | down-regulates activity
binding
|
IKBKE |
0.2 |
Identifier |
Residue |
Sequence |
Organism |
Cell Line |
SIGNOR-260592 |
|
|
Homo sapiens |
|
pmid |
sentence |
26631542 |
Previous studies have shown that MERS-CoV ORF4b antagonizes the early antiviral alpha/beta interferon (IFN-α/β) response, which may significantly contribute to MERS-CoV pathogenesis; however, the underlying mechanism is poorly understood. Here, we found that ORF4b in the cytoplasm could specifically bind to TANK binding kinase 1 (TBK1) and IκB kinase epsilon (IKKε), suppress the molecular interaction between mitochondrial antiviral signaling protein (MAVS) and IKKε, and inhibit IFN regulatory factor 3 (IRF3) phosphorylation and subsequent IFN-β production. these results indicate that MERS-CoV ORF4b inhibits the induction of type I IFN through a direct interaction with IKKε/TBK1 in the cytoplasm |
|
Publications: |
1 |
Organism: |
Homo Sapiens |
Pathways: | COVID-19 Causal Network, SARS-CoV INNATE RESPONSE TO dsRNA |
+ |
MAVS | up-regulates activity
binding
|
IKBKE |
0.824 |
Identifier |
Residue |
Sequence |
Organism |
Cell Line |
SIGNOR-260144 |
|
|
Homo sapiens |
|
pmid |
sentence |
25636800 |
After ligand binding, cGAS and RIG-I signal through respective adaptor proteins STING and MAVS to recruit the kinases IKK and TBK1, which then activate the transcription factors NF-κB and interferon regulatory factor 3 (IRF3), respectively. |
|
Publications: |
1 |
Organism: |
Homo Sapiens |
Pathways: | COVID-19 Causal Network, Innate Immune Response, SARS-CoV INNATE RESPONSE TO dsRNA |
+ |
TBK1 | up-regulates activity
binding
|
IKBKE |
0.622 |
Identifier |
Residue |
Sequence |
Organism |
Cell Line |
SIGNOR-178053 |
|
|
Homo sapiens |
|
pmid |
sentence |
18353649 |
Whereas nemo assembles some but not all ikk complexes [12,13], recent reports provide strong experimental evidence for a role of tank [also called traf-interacting protein (i-traf)], nak-associated protein (nap1) and similar to nap1 tbk1 adaptor (sintbad) in the assembly of tbk1 and ikk-e kinase complexes that phosphorylate irf3 and irf7 and promote type i ifn gene induction |
|
Publications: |
1 |
Organism: |
Homo Sapiens |
Pathways: | COVID-19 Causal Network, Innate Immune Response, SARS-CoV INNATE RESPONSE TO dsRNA, Toll like receptors |
+ |
IKBKE | up-regulates
phosphorylation
|
REL/RELA |
0.409 |
Identifier |
Residue |
Sequence |
Organism |
Cell Line |
SIGNOR-217664 |
|
|
Homo sapiens |
|
pmid |
sentence |
16888014 |
The present results demonstrate that ikkepsilon- and tbk1-mediated phosphorylation of crel in the c-terminal td leads to cytoplasmic dissociation of a crel-ikb_ complex and nuclear accumulation of crel. |
|
Publications: |
1 |
Organism: |
Homo Sapiens |
+ |
IKBKE | up-regulates activity
binding
|
TBK1 |
0.622 |
Identifier |
Residue |
Sequence |
Organism |
Cell Line |
SIGNOR-260155 |
|
|
Homo sapiens |
|
pmid |
sentence |
24622840 |
STING recruits TBK1 and IKKε and forms the TBK1-IKKε complex via the association with TRAF3. The TBK1 complex induces the phosphorylation, dimerization, and nuclear translocation of IRF3. |
|
Publications: |
1 |
Organism: |
Homo Sapiens |
Pathways: | COVID-19 Causal Network, Innate Immune Response, SARS-CoV INNATE RESPONSE TO dsRNA, Toll like receptors |
+ |
IKBKE | up-regulates
phosphorylation
|
REL |
0.365 |
Identifier |
Residue |
Sequence |
Organism |
Cell Line |
SIGNOR-148620 |
|
|
Homo sapiens |
|
pmid |
sentence |
16888014 |
The present results demonstrate that ikkepsilon- and tbk1-mediated phosphorylation of crel in the c-terminal td leads to cytoplasmic dissociation of a crel-ikb_ complex and nuclear accumulation of crel. |
|
Publications: |
1 |
Organism: |
Homo Sapiens |