3.0
Summary
| Name |  MIB2View Modifications |
| Full Name | E3 ubiquitin-protein ligase MIB2 |
| Synonyms | Mind bomb homolog 2, Novel zinc finger protein, Novelzin, Putative NF-kappa-B-activating protein 002N, Skeletrophin, Zinc finger ZZ type with ankyrin repeat domain protein 1 | SKD, ZZANK1 |
| Primary ID | Q96AX9 |
| Links |  -  -  |
| Type | protein |
| Relations | 4 |
| Function | E3 ubiquitin-protein ligase that mediates ubiquitination of Delta receptors, which act as ligands of Notch proteins. Positively regulates the Delta-mediated Notch signaling by ubiquitinating the intracellular domain of Delta, leading to endocytosis of Delta receptors. |
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Modifications Tables
Relations
| Regulator | Mechanism | target | score ℹ | |
|---|---|---|---|---|
| + | MIB2 | down-regulates activity 
polyubiquitination
|
RIPK1 | 0.3 |
| Publications: | 2 | Organism: | Homo Sapiens | |
| + | MIB2 | up-regulates 
ubiquitination
|
JAG2 | 0.803 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | Ub:E2 | up-regulates activity
ubiquitination
|
MIB2 | 0.2 |
| Publications: | 1 | Organism: | Homo Sapiens | |