Summary

Name GRIN2B
Full Name Glutamate receptor ionotropic, NMDA 2B
Synonyms GluN2B, Glutamate [NMDA] receptor subunit epsilon-2, N-methyl D-aspartate receptor subtype 2B, NMDAR2B, NR2B, N-methyl-D-aspartate receptor subunit 3, NR3, hNR3 | NMDAR2B
Primary ID Q13224
Links - -
Type protein
Relations 25
Function Component of NMDA receptor complexes that function as heterotetrameric, ligand-gated ion channels with high calcium permeability and voltage-dependent sensitivity to magnesium. Channel activation requires binding of the neurotransmitter glutamate to the epsilon subunit, glycine binding to the zeta subunit, plus membrane depolarization to eliminate channel inhibition by Mg(2+) (PubMed:8768735, PubMed:26919761, PubMed:26875626, PubMed:28126851). Sensitivity to glutamate and channel kinetics depend on the subunit composition (PubMed:8768735, PubMed:26875626). In concert with DAPK1 at extrasynaptic sites, acts as a central mediator for stroke damage. Its phosphorylation at Ser-1303 by DAPK1 enhances synaptic NMDA receptor channel activity inducing injurious Ca2+ influx through them, resulting in an irreversible neuronal death. Contributes to neural pattern formation in the developing brain. Plays a role in long-term depression (LTD) of hippocampus membrane currents and in synaptic plasticity (By similarity).

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Modifications Tables

Relations

Regulator Mechanism target score
+ up-regulates activity img/direct-activation.png phosphorylation GRIN2B 0.372
Publications: 2 Organism: In Vitro
+ up-regulates activity img/direct-activation.png phosphorylation GRIN2B 0.685
Publications: 1
+ up-regulates activity img/direct-activation.png phosphorylation GRIN2B 0.409
Publications: 2 Organism: In Vitro
+ up-regulates activity img/direct-activation.png phosphorylation GRIN2B 0.485
Publications: 2 Organism: In Vitro
+ up-regulates activity img/direct-activation.png phosphorylation GRIN2B 0.586
Publications: 1
+ down-regulates img/direct_inhibition.png phosphorylation GRIN2B 0.33
Publications: 1 Organism: Homo Sapiens
+ img/unknown.png phosphorylation GRIN2B 0.76
Publications: 8 Organism: In Vitro, Homo Sapiens,
+ up-regulates activity img/direct-activation.png phosphorylation GRIN2B 0.76
Publications: 1 Organism: In Vitro
+ down-regulates activity img/direct_inhibition.png dephosphorylation GRIN2B 0.57
Publications: 1 Organism: Mus Musculus
+ up-regulates activity img/direct-activation.png dephosphorylation GRIN2B 0.28
Publications: 1 Organism: In Vitro
+ up-regulates activity img/direct-activation.png phosphorylation GRIN2B 0.582
Publications: 1 Organism: In Vitro
+ up-regulates activity img/direct-activation.png relocalization GRIN2B 0.818
Publications: 1 Organism: Homo Sapiens
+ down-regulates quantity by repression img/direct_inhibition.png transcriptional regulation GRIN2B 0.362
Publications: 1 Organism: Rattus Norvegicus
+ form complex img/form-complex.png binding NMDA receptor_2B 0.711
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity by expression img/direct-activation.png transcriptional regulation GRIN2B 0.328
Publications: 1 Organism: Homo Sapiens
Tissue: Brain