Summary

Name RIPK1
Full Name Receptor-interacting serine/threonine-protein kinase 1
Synonyms Cell death protein RIP, Receptor-interacting protein 1, RIP-1, Serine/threonine-protein kinase RIP | RIP, RIP1
Primary ID Q13546
Links - -
Type protein
Relations 50
Pathways COVID-19 Causal Network, Death Receptor Signaling, Innate Immune Response, Inflammosome Activation, Macrophage polarization, Macrophage: Polarization and myogenesis, Macrophage: TNF alpha, Mitochondrial Control of Apoptosis, Multiple sclerosis, NF-KB Canonical, P38 Signaling and Myogenesis, SAPK/JNK Signaling, SARS-CoV INFLAMMATORY RESPONSE, SARS-CoV INNATE RESPONSE TO dsRNA, Satellite: TNFA, TNF-alpha Signaling, Tnfa_Notch_crosstalk
Inhibitors ponatinib; 5-(1H-indol-3-ylmethyl)-3-methyl-2-sulfanylidene-4-imidazolidinone
Function Serine-threonine kinase which is a key regulator of TNF-mediated apoptosis, necroptosis and inflammatory pathways (PubMed:31827280, PubMed:31827281). Exhibits kinase activity-dependent functions that regulate cell death and kinase-independent scaffold functions regulating inflammatory signaling and cell survival (PubMed:11101870, PubMed:19524512, PubMed:19524513, PubMed:29440439, PubMed:30988283). Has kinase-independent scaffold functions

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Modifications Tables

Relations

Regulator Mechanism target score
+ down-regulates activity img/direct_inhibition.png cleavage RIPK1 0.907
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png cleavage RIPK1 0.907
Publications: 1 Organism: Homo Sapiens
Pathways:COVID-19 Causal Network, Death Receptor Signaling, Mitochondrial Control of Apoptosis, TNF-alpha Signaling
+ up-regulates activity img/direct-activation.png ubiquitination, polyubiquitination RIPK1 0.737
Publications: 4 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png ubiquitination, binding RIPK1 0.889
Publications: 6 Organism: Mus Musculus, Homo Sapiens
Pathways:Multiple sclerosis, NF-KB Canonical, SAPK/JNK Signaling, TNF-alpha Signaling
+ down-regulates activity img/direct_inhibition.png polyubiquitination RIPK1 0.3
Publications: 2 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png phosphorylation DAB2IP 0.439
Publications: 2 Organism: Bos Taurus, Homo Sapiens
+ up-regulates activity img/direct-activation.png phosphorylation MAP3K1 0.427
Publications: 1 Organism: Homo Sapiens
Pathways:COVID-19 Causal Network, Macrophage polarization, SAPK/JNK Signaling, TNF-alpha Signaling
+ up-regulates activity img/direct-activation.png binding MAP3K7 0.528
Publications: 1 Organism: Homo Sapiens
Pathways:COVID-19 Causal Network, Inflammosome Activation, NF-KB Canonical, P38 Signaling and Myogenesis, SAPK/JNK Signaling, SARS-CoV INFLAMMATORY RESPONSE
+ up-regulates activity img/direct-activation.png binding RIPK1 0.635
Publications: 1 Organism: Mus Musculus
Pathways:COVID-19 Causal Network, Death Receptor Signaling, Mitochondrial Control of Apoptosis, NF-KB Canonical
+ down-regulates activity img/direct_inhibition.png chemical inhibition RIPK1 0.8
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png binding FAS 0.635
Publications: 1 Organism: Homo Sapiens
Pathways:COVID-19 Causal Network, Death Receptor Signaling, Mitochondrial Control of Apoptosis, NF-KB Canonical
+ up-regulates activity img/direct-activation.png binding RIPK1 0.784
Publications: 2 Organism: Homo Sapiens
Pathways:COVID-19 Causal Network, Death Receptor Signaling, Mitochondrial Control of Apoptosis, NF-KB Canonical, TNF-alpha Signaling
+ up-regulates img/indirect-activation.png TNFRSF10A 0.611
Publications: 1 Organism: Homo Sapiens
+ down-regulates quantity by destabilization img/direct_inhibition.png polyubiquitination RIPK1 0.737
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png binding CASP8 0.907
Publications: 2 Organism: Homo Sapiens
Pathways:COVID-19 Causal Network, Death Receptor Signaling, Mitochondrial Control of Apoptosis, TNF-alpha Signaling
+ down-regulates quantity by destabilization img/direct_inhibition.png ubiquitination RIPK1 0.522
Publications: 1 Organism: Homo Sapiens
+ down-regulates quantity by destabilization img/direct_inhibition.png ubiquitination RIPK1 0.437
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png binding RIPK1 0.935
Publications: 1 Organism: Homo Sapiens
Pathways:COVID-19 Causal Network, Death Receptor Signaling, Mitochondrial Control of Apoptosis, NF-KB Canonical, TNF-alpha Signaling
+ down-regulates quantity img/direct_inhibition.png ubiquitination RIPK1 0.638
Publications: 2 Organism: Homo Sapiens
Pathways:NF-KB Canonical
+ up-regulates activity img/direct-activation.png ubiquitination, polyubiquitination RIPK1 0.76
Publications: 4 Organism: Homo Sapiens
+ up-regulates img/indirect-activation.png Necrosis 0.7
Publications: 1 Organism: Homo Sapiens
+ down-regulates quantity by destabilization img/direct_inhibition.png polyubiquitination RIPK1 0.76
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png deubiquitination RIPK1 0.516
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png deubiquitination RIPK1 0.2
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation MAP3K1 0.427
Publications: 1 Organism: Homo Sapiens
Pathways:COVID-19 Causal Network, Macrophage polarization, SAPK/JNK Signaling, TNF-alpha Signaling
+ up-regulates activity img/direct-activation.png binding TRAF6 0.646
Publications: 1 Organism: Homo Sapiens
Pathways:COVID-19 Causal Network, Innate Immune Response, Inflammosome Activation, NF-KB Canonical, SARS-CoV INFLAMMATORY RESPONSE
+ up-regulates activity img/direct-activation.png binding TAB3 0.555
Publications: 1 Organism: Homo Sapiens
Pathways:NF-KB Canonical
+ up-regulates activity img/direct-activation.png binding TAB2 0.855
Publications: 2 Organism: Homo Sapiens
Pathways:NF-KB Canonical, P38 Signaling and Myogenesis
+ up-regulates activity img/direct-activation.png binding IKBKG 0.911
Publications: 1 Organism: Homo Sapiens
Pathways:NF-KB Canonical
+ down-regulates img/direct_inhibition.png chemical inhibition RIPK1 0.8
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png binding IKK-complex 0.658
Publications: 1 Organism: Mus Musculus
Pathways:COVID-19 Causal Network, Innate Immune Response, Inflammosome Activation, Macrophage polarization, Multiple sclerosis, NF-KB Canonical, SARS-CoV INFLAMMATORY RESPONSE, SARS-CoV INNATE RESPONSE TO dsRNA, TNF-alpha Signaling
+ up-regulates img/direct-activation.png RIPK1 0.889
Publications: 1 Organism: Homo Sapiens
Pathways:Multiple sclerosis, NF-KB Canonical, SAPK/JNK Signaling, TNF-alpha Signaling
+ up-regulates activity img/direct-activation.png binding RIPK1 0.722
Publications: 1 Organism: Homo Sapiens
Pathways:COVID-19 Causal Network, Innate Immune Response, Inflammosome Activation, Macrophage polarization, SARS-CoV INFLAMMATORY RESPONSE, SARS-CoV INNATE RESPONSE TO dsRNA