+ |
ILK | up-regulates activity
phosphorylation
|
PPP1R14B |
0.371 |
Identifier |
Residue |
Sequence |
Organism |
Cell Line |
SIGNOR-265741 |
Thr57 |
VRRQGKVtVKYDRKE |
in vitro |
|
pmid |
sentence |
12144526 |
We conclude that ILK may activate smooth-muscle contraction both directly, via phosphorylation of myosin, and indirectly, via phosphorylation and activation of CPI-17 and PHI-1, leading to inhibition of MLCP.|CPI-17 and PHI-1 thiophosphorylated by ILK at Thr(38) or Thr(57) respectively inhibited myosin light-chain phosphatase (MLCP) activity bound to myosin |
|
Publications: |
1 |
Organism: |
In Vitro |
+ |
PKC | up-regulates activity
phosphorylation
|
PPP1R14B |
0.2 |
Identifier |
Residue |
Sequence |
Organism |
Cell Line |
SIGNOR-265740 |
Thr57 |
VRRQGKVtVKYDRKE |
|
|
pmid |
sentence |
10606530 |
Recombinant tagged PHI-1 was phosphorylated by protein kinase C at two sites, one a Ser and one a Thr; phosphorylation enhanced inhibitory potency 50-fold. |
|
Publications: |
1 |
+ |
PRKCD | up-regulates activity
phosphorylation
|
PPP1R14B |
0.2 |
Identifier |
Residue |
Sequence |
Organism |
Cell Line |
SIGNOR-265739 |
Thr57 |
VRRQGKVtVKYDRKE |
|
|
pmid |
sentence |
10606530 |
Recombinant tagged PHI-1 was phosphorylated by protein kinase C at two sites, one a Ser and one a Thr; phosphorylation enhanced inhibitory potency 50-fold. |
|
Publications: |
1 |
+ |
PPP1R14B | down-regulates activity
binding
|
PPP1CB |
0.291 |
Identifier |
Residue |
Sequence |
Organism |
Cell Line |
SIGNOR-265743 |
|
|
in vitro |
|
pmid |
sentence |
12144526 |
We conclude that ILK may activate smooth-muscle contraction both directly, via phosphorylation of myosin, and indirectly, via phosphorylation and activation of CPI-17 and PHI-1, leading to inhibition of MLCP.|CPI-17 and PHI-1 thiophosphorylated by ILK at Thr(38) or Thr(57) respectively inhibited myosin light-chain phosphatase (MLCP) activity bound to myosin |
|
Publications: |
1 |
Organism: |
In Vitro |