3.0
Summary
| Name |  RNF31View Modifications |
| Full Name | E3 ubiquitin-protein ligase RNF31 |
| Synonyms | HOIL-1-interacting protein, HOIP, RING finger protein 31, RING-type E3 ubiquitin transferase RNF31, Zinc in-between-RING-finger ubiquitin-associated domain protein | ZIBRA |
| Primary ID | Q96EP0 |
| Links |  -  -  |
| Type | protein |
| Relations | 9 |
| Function | E3 ubiquitin-protein ligase component of the LUBAC complex which conjugates linear ('Met-1'-linked) polyubiquitin chains to substrates and plays a key role in NF-kappa-B activation and regulation of inflammation (PubMed:17006537, PubMed:19136968, PubMed:20005846, PubMed:21455173, PubMed:21455180, PubMed:21455181, PubMed:22863777, PubMed:28189684). LUBAC conjugates linear polyubiquitin to IKBKG and RIPK1 and is involved in activation of the canonical NF-kappa-B and the JNK signaling pathways (PubMed:17006537, PubMed:19136968, PubMed:20005846, PubMed:21455173, PubMed:21455180, PubMed:21455181, PubMed:22863777, PubMed:28189684). Linear ubiquitination mediated by the LUBAC complex interferes with TNF-induced cell death and thereby prevents inflammation (PubMed:21455173, PubMed:28189684). LUBAC is recruited to the TNF-R1 signaling complex (TNF-RSC) following polyubiquitination of TNF-RSC components by BIRC2 and/or BIRC3 and to conjugate linear polyubiquitin to IKBKG and possibly other components contributing to the stability of the complex (PubMed:20005846, PubMed:27458237). Together with OTULIN, the LUBAC complex regulates the canonical Wnt signaling during angiogenesis (PubMed:23708998). Binds polyubiquitin of different linkage types (PubMed:23708998). |
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Modifications Tables
Relations
| Regulator | Mechanism | target | score ℹ | |
|---|---|---|---|---|
| + | CASP1 | down-regulates activity 
cleavage
|
RNF31 | 0.2 |
| Publications: | 2 | Organism: | Homo Sapiens | |
| + | CASP8 | down-regulates activity
cleavage
|
RNF31 | 0.321 |
| Publications: | 2 | Organism: | Homo Sapiens | |
| + | RNF31 | up-regulates quantity by stabilization 
monoubiquitination
|
NR0B1 | 0.449 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | RNF31 | form complex 
binding
|
LUBAC | 0.945 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | RNF31 | up-regulates activity
polyubiquitination
|
CASP1 | 0.2 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | Ub:E2 | up-regulates activity
ubiquitination
|
RNF31 | 0.2 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | RNF31 | up-regulates activity
polyubiquitination
|
IKBKG | 0.844 |
| Publications: | 1 | Organism: | Homo Sapiens | |