Summary

Name CASP8
Full Name Caspase-8
Synonyms CASP-8, Apoptotic cysteine protease, Apoptotic protease Mch-5, CAP4, FADD-homologous ICE/ced-3-like protease, FADD-like ICE, FLICE, ICE-like apoptotic protease 5, MORT1-associated ced-3 homolog, MACH | MCH5
Primary ID Q14790
Links - -
Type protein
Relations 47
Pathways Alzheimer, COVID-19 Causal Network, Death Receptor Signaling, Mitochondrial Control of Apoptosis, SARS-COV APOPTOSIS, TNF-alpha Signaling
Function Thiol protease that plays a key role in programmed cell death by acting as a molecular switch for apoptosis, necroptosis and pyroptosis, and is required to prevent tissue damage during embryonic development and adulthood (By similarity). Initiator protease that induces extrinsic apoptosis by mediating cleavage and activation of effector caspases responsible for the TNFRSF6/FAS mediated and TNFRSF1A induced cell death (PubMed:23516580, PubMed:8681376, PubMed:8681377, PubMed:9006941, PubMed:9184224, PubMed:8962078). Cleaves and activates effector caspases CASP3, CASP4, CASP6, CASP7, CASP9 and CASP10 (PubMed:8962078, PubMed:9006941). Binding to the adapter molecule FADD recruits it to either receptor TNFRSF6/FAS mediated or TNFRSF1A (PubMed:8681376, PubMed:8681377). The resulting aggregate called death-inducing signaling complex (DISC) performs CASP8 proteolytic activation (PubMed:9184224). The active dimeric enzyme is then liberated from the DISC and free to activate downstream apoptotic proteases (PubMed:9184224). Proteolytic fragments of the N-terminal propeptide (termed CAP3, CAP5 and CAP6) are likely retained in the DISC (PubMed:9184224). In addition to extrinsic apoptosis, also acts as a negative regulator of necroptosis

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Modifications Tables

Relations

Regulator Mechanism target score
+ down-regulates activity img/direct_inhibition.png cleavage RIPK1 0.907
Publications: 1 Organism: Homo Sapiens
Pathways:COVID-19 Causal Network, Death Receptor Signaling, Mitochondrial Control of Apoptosis, TNF-alpha Signaling
+ up-regulates activity img/direct-activation.png cleavage PSEN2 0.338
Publications: 2 Organism: In Vitro
Pathways:Alzheimer
+ up-regulates activity img/direct-activation.png cleavage PSEN1 0.377
Publications: 2 Organism: In Vitro
Pathways:Alzheimer
+ down-regulates activity img/direct_inhibition.png cleavage RNF31 0.324
Publications: 2 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png cleavage BID 0.872
Publications: 1 Organism: Homo Sapiens
Pathways:Alzheimer, COVID-19 Causal Network, Death Receptor Signaling, Mitochondrial Control of Apoptosis, SARS-COV APOPTOSIS, TNF-alpha Signaling
+ down-regulates activity img/direct_inhibition.png polyubiquitination CASP8 0.341
Publications: 1 Organism: Homo Sapiens
+ down-regulates quantity by destabilization img/direct_inhibition.png phosphorylation CASP8 0.385
Publications: 1
+ down-regulates img/direct_inhibition.png phosphorylation CASP8 0.571
Publications: 1 Organism: Homo Sapiens
Pathways:TNF-alpha Signaling
+ down-regulates img/direct_inhibition.png phosphorylation CASP8 0.704
Publications: 1 Organism: Homo Sapiens
Tissue: Breast
+ down-regulates img/direct_inhibition.png phosphorylation CASP8 0.748
Publications: 1 Organism: Homo Sapiens
Tissue: Breast
+ down-regulates img/direct_inhibition.png phosphorylation CASP8 0.374
Publications: 1 Organism: Homo Sapiens
Tissue: Breast
+ down-regulates img/direct_inhibition.png phosphorylation CASP8 0.2
Publications: 1 Organism: Homo Sapiens
Tissue: Breast
Pathways:COVID-19 Causal Network
+ down-regulates img/direct_inhibition.png phosphorylation CASP8 0.385
Publications: 1 Organism: Homo Sapiens
Tissue: Breast
+ down-regulates quantity by destabilization img/direct_inhibition.png phosphorylation CASP8 0.383
Publications: 1
+ up-regulates activity img/direct-activation.png phosphorylation CASP8 0.349
Publications: 1
+ down-regulates img/direct_inhibition.png phosphorylation CASP8 0.473
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png dephosphorylation CASP8 0.361
Publications: 2 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png phosphorylation CASP8 0.319
Publications: 2
+ down-regulates activity img/direct_inhibition.png binding CASP8 0.755
Publications: 2 Organism: Homo Sapiens
Pathways:Death Receptor Signaling
+ up-regulates img/direct-activation.png cleavage CASP8 0.717
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/indirect-activation.png CASP9 0.59
Publications: 1 Organism: In Vitro
Pathways:COVID-19 Causal Network, Death Receptor Signaling, Mitochondrial Control of Apoptosis, SARS-COV APOPTOSIS
+ down-regulates img/direct_inhibition.png binding CASP8 0.379
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png binding CASP8 0.907
Publications: 2 Organism: Homo Sapiens
Pathways:COVID-19 Causal Network, Death Receptor Signaling, Mitochondrial Control of Apoptosis, TNF-alpha Signaling
+ form complex img/form-complex.png binding Caspase 8 complex 0.2
Publications: 1
+ up-regulates activity img/direct-activation.png cleavage CASP3 0.707
Publications: 3 Organism: Homo Sapiens, Mus Musculus
Pathways:Alzheimer, COVID-19 Causal Network, Death Receptor Signaling, Mitochondrial Control of Apoptosis, SARS-COV APOPTOSIS, TNF-alpha Signaling
+ up-regulates img/direct-activation.png relocalization CASP8 0.57
Publications: 1 Organism: Homo Sapiens
Pathways:COVID-19 Causal Network
+ up-regulates img/direct-activation.png cleavage CASP6 0.717
Publications: 1 Organism: Homo Sapiens
Pathways:COVID-19 Causal Network, SARS-COV APOPTOSIS
+ up-regulates img/direct-activation.png cleavage CASP7 0.724
Publications: 2 Organism: Homo Sapiens
+ up-regulates img/indirect-activation.png Cell_death 0.7
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png binding CASP8 0.906
Publications: 1 Organism: Homo Sapiens
Pathways:Alzheimer, COVID-19 Causal Network, Death Receptor Signaling, Mitochondrial Control of Apoptosis, SARS-COV APOPTOSIS, TNF-alpha Signaling
+ up-regulates img/direct-activation.png binding CASP8AP2 0.462
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/indirect-activation.png Apoptosis 0.7
Publications: 1 Organism: Homo Sapiens
Pathways:Alzheimer, COVID-19 Causal Network, Death Receptor Signaling, Mitochondrial Control of Apoptosis, SARS-COV APOPTOSIS, TNF-alpha Signaling
+ down-regulates img/direct_inhibition.png phosphorylation CASP8 0.2
Publications: 1 Organism: Homo Sapiens
Tissue: Breast
+ up-regulates activity img/indirect-activation.png CYCS 0.502
Publications: 1 Organism: Homo Sapiens
Pathways:Alzheimer, COVID-19 Causal Network, Death Receptor Signaling, Mitochondrial Control of Apoptosis, SARS-COV APOPTOSIS
+ up-regulates activity img/indirect-activation.png CASP8 0.2
Publications: 1 Organism: Homo Sapiens
Pathways:COVID-19 Causal Network, SARS-COV APOPTOSIS
+ up-regulates img/direct-activation.png cleavage CASP8 0.717
Publications: 1 Organism: Homo Sapiens
Pathways:COVID-19 Causal Network, SARS-COV APOPTOSIS
+ up-regulates activity img/direct-activation.png binding CASP8 0.929
Publications: 1 Organism: Homo Sapiens
Pathways:Alzheimer, COVID-19 Causal Network, Death Receptor Signaling, Mitochondrial Control of Apoptosis, SARS-COV APOPTOSIS, TNF-alpha Signaling