| + |
MAPK1 | down-regulates activity 
phosphorylation
|
DAZAP1 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-262970 |
Thr269 |
FTSYIVStPPGGFPP |
Homo sapiens |
HEK-293 Cell |
| pmid |
sentence |
| 16848763 |
Further experiments showed that DAZAP1 was phosphorylated stoichiometrically in vitro by ERK2 (extracellular-signal-regulated protein kinase 2) at two Thr-Pro sequences (Thr269 and Thr315), and that both sites became phosphorylated in HEK-293 (human embryonic kidney 293) cells in response to PMA or EGF (epidermal growth factor), or RAW 264.7 macrophages in response to LPS. Phosphorylation of the ARE-binding protein DAZAP1 by ERK2 induces its dissociation from DAZ |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-262971 |
Thr315 |
GVPPPPAtPGAAPLA |
Homo sapiens |
HEK-293 Cell |
| pmid |
sentence |
| 16848763 |
Further experiments showed that DAZAP1 was phosphorylated stoichiometrically in vitro by ERK2 (extracellular-signal-regulated protein kinase 2) at two Thr-Pro sequences (Thr269 and Thr315), and that both sites became phosphorylated in HEK-293 (human embryonic kidney 293) cells in response to PMA or EGF (epidermal growth factor), or RAW 264.7 macrophages in response to LPS. Phosphorylation of the ARE-binding protein DAZAP1 by ERK2 induces its dissociation from DAZ |
|
| Publications: |
2 |
Organism: |
Homo Sapiens |
3.0
DAZAP1
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